Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial

Staessen, Cathérine; Platteau, Peter; Assche, Elvire Van; Michiels, An; Tournaye, Herman; Camus, Michel; Devroey, Paul; Liebaers, Ingeborg; Steirteghem, André Van

doi:10.1093/humrep/deh536

Cited by 485 publications

(330 citation statements)

References 51 publications

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“…L'opposition française au « diagnostic » de sexe embryonnaire pour convenance personnelle a été exprimée sans ambiguïté [14]. Au niveau mondial, le bénéfice d'une recherche d'aneuploïdie embryonnaire reste largement discuté [15][16][17]. Un développement plus récent concerne la possibilité de sélectionner des embryons selon les antigènes d'histocompatibilité lymphocytaire (HLA) qu'ils ont reçus de leurs parents, de sorte qu'ils soient immunologiquement compatibles avec un frère ou une soeur malade et néces-sitant une greffe de moelle [18].…”

Section: Le Débat éThiqueunclassified

Diagnostic prénatal et diagnostic pré-implantatoire : arbre décisionnel, nouvelles pratiques ?

et al. 2005

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Section: Le Débat éThiqueunclassified

Diagnostic prénatal et diagnostic pré-implantatoire : arbre décisionnel, nouvelles pratiques ?

et al. 2005

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“…But, whereas non-randomized PGS or PCS studies published worldwide report an increase in implantation rate and/or a decrease in miscarriage rate [11][12][13], controlled trials of PGS performed for AMA [14][15][16] and for RIF [17] have shown no benefit of PGS. Implantation and pregnancy rates were similar for women with or without PGS.…”

Section: Introductionmentioning

confidence: 99%

Are zona pellucida laser drilling and polar body biopsy safe for in vitro matured oocytes?

Hammoud

Molina-Gomès

Albert

et al. 2010

J Assist Reprod Genet

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Introduction Preconception diagnosis requires first polar body biopsy. When the hole in the zona pellucida is made with a laser beam, heat propagation could, like the biopsy itself, be deleterious. Our aim was to evaluate the effect of this technique on human in vitro matured oocyte and embryo development. Methods One hunded fifty five retrieved immature oocytes from 75 women, matured in vitro, were distributed in 3 groups: 50 oocytes in a control group, without laser drilling and first polar body biopsy, 52 oocytes in a group with only laser drilling, and 53 oocytes in a group with both laser drilling and first polar body biopsy. Safety was evaluated using four criteria: [1] oocyte lysis rate, [2] oocyte activation rate, [3] oocyte development after calcium ionophore treatment, [4] and embryo chromosome breakage incidence after Tarkowski preparation. Results No difference in the four criteria was observed between the 3 oocyte groups.Conclusions We did not find evidence of deleterious effect of laser drilling and first polar body biopsy on in vitro matured oocytes, according to our criteria.

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“…A recent Cochrane review found that blastocyst ET has a statistically significant higher live birth rate than cleavage stage ET, 32-42 vs 31 % respectively [7]. Furthermore, longer cell culture allows for improved selection of higher grade embryos and decreases the rate of aneuploidy [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A comparison of pregnancy outcomes between day 3 and day 5/6 embryo transfers: does day of embryo transfer really make a difference?

Maxwell

Melzer-Ross²,

McCulloh

et al. 2015

J Assist Reprod Genet

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Purpose To determine if day of embryo transfer (ET) affects gestational age (GA) and/or birth weight (BW) at a single university fertility center that primarily performs day 5/6 ET. Methods Retrospective cohort study of 2392 singleton live births resulting from IVF/ICSI at a single large university fertility center from 2003 to 2012. Patients were stratified by day 3 or day 5/6 ET. Outcome variables included patient age, gravidity, prior miscarriages, prior assisted reproduction technology cycles, number of embryos transferred, number of single ET, infertility diagnosis, neonatal sex, GA at birth, and BW. Subanalyses were performed on subgroups of preterm infants. A comparison was made between the study data and the Society of Assisted Reproductive Technologies (SART) published data. Results There was no difference in GA at birth (39±2.1 weeks for day 3 ET, 39±1.9 weeks for day 5/6 ET) or BW between ET groups (3308±568 g for day 3 ET, 3268±543 g for day 5/6 ET). There was also no difference in the number of preterm deliveries (8.5 % for day 3 ET vs. 10.8 % for day 5/6 ET). The day 5/6 ET study data had significantly fewer pre-term deliveries than the SART day 5/6 ET data. Conclusion In contrast to published SART data, GA and BW were not influenced by day of ET. Data may be more uniform at a single institution. Day 5/6 ET continues to offer improved pregnancy rates without compromising birth outcomes.

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Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial

Abstract: This RCT provides no arguments in favour of PGD-AS for improving clinical outcome per initiated cycle in patients with AMA when there are no restrictions in the number of embryos to be transferred.

Cited by 485 publications

References 51 publications

Diagnostic prénatal et diagnostic pré-implantatoire : arbre décisionnel, nouvelles pratiques ?

Diagnostic prénatal et diagnostic pré-implantatoire : arbre décisionnel, nouvelles pratiques ?

Are zona pellucida laser drilling and polar body biopsy safe for in vitro matured oocytes?

A comparison of pregnancy outcomes between day 3 and day 5/6 embryo transfers: does day of embryo transfer really make a difference?

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