Comparison of blastocyst transfer with day 3 embryo transfer in similar patient populations

Milki, Amin A.; Hinckley, Mary D; Fisch, Jeffrey D; Dasig, D.; Behr, Barry

doi:10.1016/s0015-0282(99)00485-9

Cited by 168 publications

(82 citation statements)

References 12 publications

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“…Moreover, embryos capable of reaching blastocyst stage for transfer are in greater chance of success. It has been recognized that there were better synchronization between embryo and endometrium, and better embryo quality in blastocyst transfer (30). Whether or not prolonged in vitro culture to day-5 modified the influences upon embryo quality or endometrial receptivity from weather environment requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

The influences of weather on patients with different ovarian responses in the treatment of assisted reproductive technology

Chang

Lan

Chen

et al. 2005

J Assist Reprod Genet

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Purpose : The purpose of this study was to evaluate the influences of tropical weather on patients with different ovarian responses in the treatment of assisted reproductive technology. Methods: Six-hundred fourty-seven women underwent their first treatment cycles were retrospectively analyzed. Patients received embryo transfer either 3 days or 5 days after oocyte retrieval, depending on the number and quality of embryos on day-2.Results : Significant correlations were demonstrated in the top quality embryo rates of day-3 and day-5 embryo transfers with temperature, humidity, and atmosphere pressure. The cumulative light hours negatively correlated with the implantation and pregnancy rates of day-3 embryo transfer (−.282 and −.282, respectively), while they positively correlated with those of day-5 embryo transfer (.225 and .224, respectively). Conclusions : These results clearly suggest that weather may exert influences on the outcome of assisted reproductive technology. Patients with different ovarian responses or blastocyst culture and transfer may modify weather influences.

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Section: Discussionmentioning

confidence: 99%

The influences of weather on patients with different ovarian responses in the treatment of assisted reproductive technology

Chang

Lan

Chen

et al. 2005

J Assist Reprod Genet

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“…The introduction in 1998 of blastocyst culture caused us to reevaluate our embryo culture and cryopreservation strategy. The initial studies on blastocyst transfer showed that the two possible advantages of blastocyst culture were an improved rate of pregnancy in the fresh cycle and a decrease in high-order multiple pregnancies (14)(15)(16). We sought to determine whether additional strategies could enhance our long-standing approach of cryopreserving extra embryos at the PN-S. We were interested in determining whether this enhanced approach might be an effective alternative to the more commonly used strategy of leaving all embryos in culture for selection of the best embryos at the cleavage or blastocyst stages.…”

Section: Discussionmentioning

confidence: 99%

“…These were higher than those reported in most blastocyst studies even though only 0.88, 0.80, and 0.61 more embryos were cultured for Groups I, II, and III, respectively, than the number transferred. Pregnancy and implantation rates with blastocyst transfer have ranged from 21 to 77% and 9-62%, respectively (2,5,6,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). With blastocyst transfer, all embryos are retained in culture to ensure at least two high-quality blastocysts are available for transfer.…”

Section: Discussionmentioning

confidence: 99%

“…During the past decade, increasing emphasis has been placed on limiting IVF-ET multiple pregnancies (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)29,(31)(32)(33)(34). Culture of embryos to the blastocyst stage has been advocated as a method for reducing multiple births while maintaining high fresh cycle pregnancy rates (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…Culture of embryos to the blastocyst stage has been advocated as a method for reducing multiple births while maintaining high fresh cycle pregnancy rates (15,16). To date, blastocyst transfers have reduced high-order multiple pregnancies, that is triplet or greater, but not overall multiple rates (16,21,31).…”

Section: Discussionmentioning

confidence: 99%

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Selection of Embryos for Day-3 Transfer at the Pronuclear-Stage and Pronuclear-Stage Cryopreservation Results in High Delivery Rates in Fresh and Frozen Cycles

Hammitt

Sattler

Manes

et al. 2004

J Assist Reprod Genet

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Purpose : Evaluate IVF-ET outcome data for a unique culture and cryopreservation strategy. Methods : Retrospective study of 92 patients. Embryos for day-3 transfer were selected at pronuclear-stage; all extra zygotes were cryopreserved at pronuclear-stage. Results : Delivery rates for Anonymous Oocyte Donation (Group I), patients <35 years (Group II), and 35-38 years (Group III) were 52.9%, 61.5%, and 51.7% for fresh and 38.5%, 33.3%, and 40.0% for frozen transfer. Deliveries per retrieval were 82.3%, 71.8%, and 58.6%. Only 0.88, 0.80, and 0.61 more zygotes were cultured than what were used for fresh transfer. Singleton, twin, and triplet rates were 64.6%, 31.2%, and 4.2% for fresh and 69.2%, 30.8%, and 0% for frozen. Conclusions : Selection of day-3 transfer embryos at the pronuclear-stage and cryopreservation of extra zygotes results in high delivery rates in fresh and frozen cycles. This approach optimizes deliveries per retrieval and provides many patients with more than one pregnancy per retrieval.

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FISH analysis on day 5 post‐insemination of human arrested and blastocyst stage embryos

et al. 2000

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Preimplantation genetic diagnosis (PGD) is usually performed on cleavage stage embryos on day 3 post‐insemination. Fluorescent in situ hybridization (FISH) has revealed four groups of chromosome patterns in embryos at this stage: uniformly normal, uniformly abnormal, mosaic and chaotic. Recently, some in vitro fertilization (IVF) clinics have started to perform blastocyst stage transfer. In blastocysts, conventional karyotyping has shown that all four groups of chromosome patterns are observed. In the present study, embryos were cultured to day 5 and were subject to a two‐round multicolour FISH procedure for chromosome analysis to ensure almost every nucleus was examined. Probes for chromosomes X, Y and 18 were used in the first round and those for chromosomes 13 and 21 in the second round. Twenty arrested embryos (274 cells) and 19 blastocyst stage embryos (1272 cells) were analysed. Four arrested embryos and two blastocysts were uniformly diploid. The remaining 33 embryos were mosaic, including 17 blastocysts. Most of the blastocysts had a high proportion of diploid cells while in the arrested embryos, this proportion varied widely. For PGD, this high prevalence of mosaicism persisting to the blastocyst stage may pose problems similar to mosaicism in cleavage stage embryos. Copyright © 2000 John Wiley & Sons, Ltd.

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Comparison of blastocyst transfer with day 3 embryo transfer in similar patient populations

Cited by 168 publications

References 12 publications

The influences of weather on patients with different ovarian responses in the treatment of assisted reproductive technology

The influences of weather on patients with different ovarian responses in the treatment of assisted reproductive technology

Selection of Embryos for Day-3 Transfer at the Pronuclear-Stage and Pronuclear-Stage Cryopreservation Results in High Delivery Rates in Fresh and Frozen Cycles

FISH analysis on day 5 post‐insemination of human arrested and blastocyst stage embryos

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