Comparison of blood lead concentrations in patients with acute ischemic stroke and healthy subjects

Mousavi-Mirzaei, Seyed Mohammad; Khorasani, Emad Yeganeh; Amirabadizadeh, Alireza; Nakhaee, Samaneh; Baharshahi, Amin; Rajabpour-Sanati, Ali; Talebi, Abolfazl; Lamarine, Roland J.; Mehrpour, Mahsa; Mehrpour, Omid

doi:10.1016/j.jtemb.2020.126532

Cited by 11 publications

(11 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…59 Recently, a case-control study also reported that the lead in the blood is significantly associated with acute stroke (OR: 1.04, 95% CI: 1.02-1.07 per 1 µg/dL in blood lead), suggesting a risk factor for ischaemic stroke. 63 Nevertheless, other studies did not observe a significant association. A prospective cohort study of the effect of blood lead on mortality due to stroke reported that the risk of stroke mortality did not differ according to blood lead level in older women (OR: 1.13, 95% CI: 0.34-3.81).…”

Section: Discussionmentioning

confidence: 90%

Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study in the Korea National Health and Nutrition Examination Survey 2008–2013

et al. 2020

View full text Add to dashboard Cite

ObjectivesAlthough lead is a potential risk factor for cardiovascular diseases such as stroke, research on this association in the Korean population remains limited. Therefore, we aimed to investigate the association between lead level and stroke in Korean adults.DesignA population-based cross-sectional study.SettingThe Korea National Health and Nutrition Examination Survey 2008–2013, which enrolled a representative sample of the Korean population.ParticipantsWe excluded participants younger than 20 years, missing weight data, pregnant or lactating, and missing blood lead and stroke data. A total of 11 510 participants were included in this analysis.Primary and secondary outcome measurementThe participants were classified by blood lead concentration into the low-level (≤2.189 µg/dL, n=5756) and high-level (>2.189 µg/dL, n=5754) groups. The main outcome, stroke, was assessed by information from physician diagnosis, prevalence of stroke or treatment for stroke. The ORs and 95% CIs were calculated to evaluate the association between blood lead level and stroke using multivariate logistic regression analysis.ResultsAlthough blood lead level was not significantly associated with stroke (OR: 1.30, 95% CI: 0.66–2.58) in the multivariate-adjusted model, in individuals with hypertension, the high-level group was 2.36-fold higher odds of stroke (OR: 2.36, 95% CI: 1.02–5.44) compared to that in the low-level group. No association was observed in individuals with normotension (OR: 0.42, 95% CI: 0.13–1.38, p for interaction=0.007).ConclusionThe association between blood lead concentration and stroke may be influenced by hypertension status. Our findings suggest the need for closer attention to lead exposure in patients with hypertension.

show abstract

Section: Discussionmentioning

confidence: 90%

Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study in the Korea National Health and Nutrition Examination Survey 2008–2013

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Arrhythmias, hypoxia, hypotension, vasospasm, atherosclerosis, thrombus formation, and embolism may cause ischemic strokes [31, 32]. The risk, etiology, and type of stroke vary according to the type and route of drug administration [31, 33], therapeutic usage [34, 35], and the purity of drugs [36-38]. For example, opioids may cause ischemic stroke due to cardiac dysrhythmia [39], endocarditis [31], and atherosclerosis [40].…”

Section: Discussionmentioning

confidence: 99%

The Association between Substance Use Disorders and Long-Term Outcome of Stroke: Results from a Population-Based Study of Stroke among 450,229 Urban Citizens

et al. 2021

View full text Add to dashboard Cite

Introduction: Little is known regarding long-term stroke outcomes in patients with substance use disorder (SUD). Based on anecdotal data, some individuals use illicit drugs, particularly opioids, in an attempt to reduce stroke mortality, disability, or recurrence. This study is aimed to assess the effect of SUD on stroke outcomes. Methods: Patients were recruited from the Mashhad Stroke Incidence Study, a population-based study of stroke in Iran. For a period of 1 year, all patients with first-ever stroke (FES) were recruited and then followed up for the next 5 years. Disability and functional dependency were defined using modified Rankin Scale (>2) and Barthel Index (<60), respectively. We compared the cumulative rates of mortality in follow-up points using the log-rank test. We used multivariable logistic, Cox regression and competing risk models to assess adjusted hazard ratio (aHR) with 95% confidence interval (CI) of stroke disability, functional dependency, mortality, and recurrence among those with a history of SUD. Results: 595 FES patients (mean age of 64.6 ± 14.8 years) were recruited in this study. Eighty-one (13.6%) were current substance users, including opium (n = 68), naswar (n = 5, 6.1%), hashish (n = 1), heroin (n = 1), and (n = 7) others. The frequency of vascular risk factors was similar between the SUD and non-SUD groups, except for a higher rate of cigarette smoking in the SUD group (p < 0.001). After adjusting for various sociodemographic variables, vascular risk factors, and the severity of stroke at admission, SUD increased the 3-month (aHR: 1.60, CI: 1.01–2.49), 1-year (aHR: 1.73, CI: 1.20–2.65), and 5-year (aHR: 1.72, CI: 1.23–2.35) poststroke mortality risk. We did not observe a significant change in the risk of stroke recurrence, disability, and functional dependency in those with a history of SUD. Conclusion: SUD increased the hazard ratio of stroke mortality with no effect on the disability rate. The public should be advised about the potential harm of substance abuse.

show abstract

“…Some studies have reported that opium addiction increases the risk of stroke, 5 and could be a risk factor for ischemic stroke. 6 However, there have been few studies on the risk factors for early death in these patients.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of the sequential organ failure assessment (SOFA) score for prognosis in patients with severe acute ischemic stroke: a retrospective study

et al. 2020

View full text Add to dashboard Cite

Objective To identify the risk factors for early death and determine the predictive value of the sequential organ failure assessment (SOFA) score for prognosis of severe acute ischemic stroke (AIS). Methods A total of 110 patients with severe AIS were enrolled and divided into the non-survivor (n = 34) and survivor groups (n = 76). Logistic regression analysis was conducted to identify risk factors for early death, while the receiver operator characteristic (ROC) curve was used to determine the predictive effect of the SOFA score on prognosis. Results Logistic regression analysis showed that urinary tract infection (odds ratio [OR] = 17.364, 95% confidence interval [CI]: 1.903–158.427), mechanical ventilation (OR = 1.754, 95% CI: 1.648–2.219), and osmotic therapy (OR = 2.835, 95% CI: 1.871–5.102) were significantly correlated with early death of severe AIS. ROC curve analysis of the area under the curve after hospitalization showed that the maximum SOFA and ΔSOFA scores exceeded 0.7. Conclusion Our study shows that urinary tract infection, mechanical ventilation, and osmotic therapy are risk factors for early death of severe AIS. The SOFA score has good predictive value for prognosis of severe AIS. These findings may provide a guideline for improving clinical outcome.

show abstract

Comparison of blood lead concentrations in patients with acute ischemic stroke and healthy subjects

Cited by 11 publications

References 45 publications

Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study in the Korea National Health and Nutrition Examination Survey 2008–2013

Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study in the Korea National Health and Nutrition Examination Survey 2008–2013

The Association between Substance Use Disorders and Long-Term Outcome of Stroke: Results from a Population-Based Study of Stroke among 450,229 Urban Citizens

Predictive value of the sequential organ failure assessment (SOFA) score for prognosis in patients with severe acute ischemic stroke: a retrospective study

Contact Info

Product

Resources

About