Comparison of breast cancer detection by diffusion-weighted magnetic resonance imaging and mammography

Yoshikawa, Miho; Ohsumi, Shozo; Sugata, Shigenori; Kataoka, Makoto; Takashima, Shigemitsu; Kikuchi, Keiichi; Mochizuki, Takashi

doi:10.1007/s11604-007-0128-4

Cited by 64 publications

(56 citation statements)

References 15 publications

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“…In a study by Choi et al (30) /sec and the mean ADC value of 6 DCIS lesions was 1.305x10 -3 mm 2 /sec when the b value was 1000. The reasons for this difference were that invasive ductal carcinoma is a type of cancer that is heavier with cells and it restricts water diffusion more compared with DCIS (32,33).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

Akın¹,

Uğurlu²,

Kaya³

et al. 2016

J Breasth Health

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IntroductionMagnetic resonance imaging (MRI) as a method for breast exams has been used increasingly frequently during the last decade. In particular, it is preferred for selected cases as a diagnostic and problem-solving method for its high contrast resolution, multiplanar capability of examination, lack of ionizing radiation, and capacity to obtain dynamic contrast images (1, 2). Conventional MRI has disadvantages such as time-consuming screening and requirement of high-value contrast agents (3). Despite the fact that dynamic contrast-enhanced MRI is an efficient diagnostic exam with high sensitivity, but its limited specificity creates a need for new techniques (1-7). Therefore, additional sequences are sought that would increase image quality, reduce imaging time and enable differential diagnosis for lesions (4). Diffusionweighted imaging (DWI) is one of these fast MRI sequences. By recording the free movement of water molecules in the extracellular space, DWI creates different signals in images as a result of the inhibition of this movement and therefore diffusion restriction, which occurs due to an increase in cell frequency in the presence of a malignant mass. The apparent diffusion coefficient (ADC) is a quantitative measure of the diffusion of water molecules within tissue. Using the data in various b-values obtained from DWI in MRI, ADC maps are created and ADC values of lesions can be calculated (8,9). Recent studies showed that DWI and ADC measurements had high rates of accuracy and specificity in the differential diagnosis of malignant and benign breast lesions (10-13).Breast cancer is a heterogeneous disease, and its natural course after diagnosis varies among patients. In the follow-up of patients with tumors of the same diameter, some experience tumor recurrence after a very short time, whereas others continue living a healthy life. Therefore, prognostic factors and molecular subgroups are used in order to determine differences between clinical and biologic behaviors of patients with breast cancer and establish the high-risk group, which demonstrates a quick disease progression (14-17). Although some of these factors (tumor diameter, axillary involvement, histologic characteristics of tumor, hormone receptors) have a well-known role in determining prognosis, there is ongoing intensive research regarding hormone receptors, tumor proliferation rate, and molecular prog- Breast Health 2016; 12: 123-132 DOI: 10.5152/tjbh.2016 12: 123-132 DOI: 10.5152/tjbh. .2897 123 ABSTRACT Objective: The aim of this study was to evaluate the effect of the apparent diffusion coefficient (ADC) and diffusion-weighted imaging in differentiating benign from malignant breast lesions, histopathologic subtypes of breast tumors, and to find a correlation with prognostic factors using 3T MR. Materials and Methods:A total of 165 patients aged between 16 and 78 years with 181 histopathologically-verifed breast lesions were enrolled in this study. A 3T MR system and bilateral phased array breast coil was used. Diffusion-weigh...

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Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

Akın¹,

Uğurlu²,

Kaya³

et al. 2016

J Breasth Health

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“…One study (46) conducted a cost-effective analysis regarding WB-MRI. They concluded that substantial savings are achievable with the use of WB-MRI for preoperative tumor staging.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysis

Zheng

et al. 2011

Magnetic Resonance Imaging

117

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Purpose: To assess the overall diagnostic accuracy of whole-body magnetic resonance imaging (WB-MRI) in detecting bone metastases with a meta-analysis. Materials and Methods:The MEDLINE, EMBASE, Cancerlit, and Cochrane Library databases were searched from January 1995 to September 2010 for studies evaluating the accuracy of WB-MRI in detecting bone metastases. Histopathologic analysis and/or close clinical and imaging follow-up for at least 6 months was assessed. Meta-analysis methods were used to pool sensitivity and specificity and to construct summary receiver-operating characteristics.Results: A total of 11 studies with 495 patients who fulfilled all of the inclusion criteria were considered for the analysis. No publication bias was found. WB-MRI had a pooled sensitivity of 0.899 (95% confidence interval [CI], 0.845-0.939) and a pooled specificity of 0.918 (95% CI, 0.882-0.946). The subgroup without diffusion-weighted imaging (DWI) positive results had higher pooled specificity 0.961 (95% CI, 0.922-0.984) than the subgroup with DWI (P < 0.05).Conclusion: WB-MRI was an accurate, cost-effective tool in detecting bone metastases. WB-MRI without DWI may improve the specificity of detecting bone metastases. DWI seems to be a sensitive but rather unspecific modality for the detection of bone metastatic disease. High-quality prospective studies regarding WB-MRI in detecting bone metastases still need to be conducted.

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“…The principle of the DWI is related to the Brownian movement of the water particles, which is restricted due to structure of the environment depending on the cellularity degree of the lesions (18,19). The apparent diffusion coefficient (ADC) value as a quantitative measurement of diffusion has been observed by several studies to further help lesion characterization and discrimination when evaluated along with DCE-MRI (20)(21)(22).…”

mentioning

confidence: 99%

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

T¹,

G²,

Sezgin³

et al. 2016

Balkan Med J

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Background: Magnetic resonance imaging (MRI) has become a diagnostic and problem solving method for the breast examinations in addition to conventional breast examination methods. Diffusion-weighted imaging (DWI) adds valuable information to conventional MRI. Aims: Our aim was to show the impact of apparent diffusion coefficient (ADC) values acquired with DWI to differentiate benign and malignant breast lesions. Study Design: Diagnostic accuracy study. Methods: Forty-six women with 58 breast masses (35 malignant, 23 benign) were examined on a 1.5 T clinical MRI scanner. The morphologic characteristics of the lesions on conventional MRI sequences and contrast uptake pattern were assessed. ADC values of both lesions and normal breast parenchyma were measured. The ADC values obtained were statistically compared with the histopathologic results using Paired Samples t-Test. Results: Multiple lesions were detected in 12 (26%) of the patients, while only one lesion was detected in 34 (74%). Overall, 35 lesions out of 58 were histopathologically proven to be malignant. In the dynamic contrast-enhanced series, 5 of the malignant lesions were type 1, while 8 benign lesions revealed either type 2 or 3 time signal intensity curves (85% sensitivity, 56% spesifity Breast cancer is the most common cancer in females worldwide and the second main cause of cancer death following lung cancer. Approximately 12% of women will experience breast cancer during their lifetime (1). Therefore, breast cancer maintains its importance as a serious public health issue. The major risk factors comprise family history, genetic predisposition caused by the presence of a BRCA1 or BRCA2 gene mutation, and previously acquired breast lesions including fibrovascular papilloma, atypical ductal and lobular hyperplasia, and ductal and lobular carcinoma in situ (2,3).Imaging is crucial to diagnose and evaluate the stage and extent of breast cancer. Therefore, three types of radiologic techniques, including mammography, ultrasonography (US) and breast magnetic resonance imaging (MRI), are implemented. As a basic breast cancer scanning method, mammography is highly available, with a short scanning time.

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Comparison of breast cancer detection by diffusion-weighted magnetic resonance imaging and mammography

Abstract: DW-MRI may be useful for detecting breast cancer in a wide age group of women, including young women with dense mammary glands.

Cited by 64 publications

References 15 publications

Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysis

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

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