Comparison of Bupivacaine and Alkalinized Bupivacaine in Brachial Plexus Anesthesia

Bedder, Marshall D.; Kozody, R.; Craig, Douglas B.

doi:10.1213/00000539-198801000-00009

Cited by 27 publications

(16 citation statements)

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“…Only few studies were conducted to compare the efficacy of carbonated bupivacaine with adrenaline with that of bupivacaine hydrochloride with adrenaline for surgical removal of impacted tooth. Few studies have compared the efficacy of bupivacaine hydrochloride and alkalinized bupivacaine in brachial plexus anesthesia; the results show less pain on injection and rapid onset of anesthesia for alkalinized bupivacaine than bupivacaine hydrochloride [21]. We agree with them in terms of less pain on injection and rapid onset of anesthesia for carbonated bupivacaine with adrenaline than bupivacaine with adrenaline.…”

Section: Discussionsupporting

confidence: 61%

A Comparative Study Between Bupivacaine with Adrenaline and Carbonated Bupivacaine with Adrenaline for Surgical Removal of Impacted Mandibular Third Molar

Shyamala¹,

Ramesh²,

Yuvaraj³

et al. 2015

J. Maxillofac. Oral Surg.

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Objectives To compare the effectiveness of bupivacaine with adrenaline with that of carbonated bupivacaine with adrenaline on pain, onset of anesthesia and duration of anesthesia following surgical removal of impacted mandibular third molar. Study design All the patients who underwent surgical removal of impacted mandibular third molar and who fulfilled our inclusion and exclusion criteria from 1st June 2013 to 30th June 2014 were included in our study. Patients who were diagnosed as having impacted mandibular third molar were randomly allocated to two groups namely group A (bupivacaine with adrenaline), group B (carbonated bupivacaine with adrenaline). Pain during deposition of local anesthetic, onset of anesthesia and duration of anesthesia were compared between the two groups. The collected data were subjected to statistical analysis by Chi Square test, Mann-Whitney U test. Results and conclusion The efficacy of carbonated bupivacaine with adrenaline is more compared with bupivacaine with adrenaline in decreasing pain on deposition of local anesthetic solution and in rapid onset of anesthesia. The duration of anesthesia for carbonated bupivacaine with adrenaline and bupivacaine with adrenaline had no significant difference. The use of carbonated bupivacaine with adrenaline will reduce the patient discomfort both intraoperatively and post-operatively.

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Section: Discussionsupporting

confidence: 61%

A Comparative Study Between Bupivacaine with Adrenaline and Carbonated Bupivacaine with Adrenaline for Surgical Removal of Impacted Mandibular Third Molar

Shyamala¹,

Ramesh²,

Yuvaraj³

et al. 2015

J. Maxillofac. Oral Surg.

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show abstract

“…Sensory block was evaluated by temperature testing using spirit soaked cotton on skin dermatomes C4-T2, whereas motor block was assessed by asking the patient to adduct the shoulder and flex the forearm and hand against gravity. 9 Onset of sensory block was defined as the time elapsed between injection of drug and complete loss of cold perception of the hand, while onset of motor block was defined as the time elapsed from injection of drug to complete motor block. Only patients with complete motor block were included in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Various studies have investigated several adjuncts, including opioids, clonidine, neostigmine, hyaluronidase, and bicarbonate. [5][6][7][8][9] The results have been inconclusive, because of associated side effects or doubtful efficacy. Midazolam, a water-soluble benzodiazepine, is known to produce antinociception and to enhance the effect of local anesthetic when given epidurally or intrathecally.…”

Section: Conclusion : Le Midazolam (50 µG·kg -1 ) Combiné à 30 ML De mentioning

confidence: 99%

Brachial plexus block with midazolam and bupivacaine improves analgesia

Jarbo

Batra

Nidhi

et al. 2005

Can J Anesth/J Can Anesth

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Purpose: Adjuncts to local anesthetics for brachial plexus block may enhance the quality and duration of analgesia. Midazolam, a water-soluble benzodiazepine, is known to produce antinociception and enhance the effect of local anesthetics when given epidurally or intrathecally. The purpose of this study was to assess the effect of midazolam added to brachial plexus anesthesia. Methods:A prospective, randomized, double blind study was conducted on 40 ASA I or II adult patients undergoing upper limb surgeries under supraclavicular brachial plexus block. Patients were randomly divided into two groups. Patients in Group B (n = 20) were administered 30 mL of 0.5% bupivacaine and Group BM (n = 20) were given 30 mL of 0.5% bupivacaine with midazolam 50 µg·kg -1 . Hemodynamic variables (i.e., heart rate, noninvasive blood pressure), pain scores and rescue analgesic requirements were recorded for 24 hr postoperatively. Results:The onset of sensory and motor block was significantly faster in Group BM compared to Group B (P < 0.05). Pain scores were significantly higher in Group B compared to Group BM from two hours to 24 hr postoperatively (P < 0.05). Rescue analgesic requirements were significantly less in Group BM compared to Group B (P < 0.05). Hemodynamics and sedation scores did not differ between groups in the postoperative period. Conclusion:Midazolam (50 µg·kg -1 ) in combination with 30 mL of bupivacaine (0.5%) hastened onset of sensory and motor block, and improved postoperative analgesia when used in brachial plexus block, without producing any adverse events. Objectif

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“…1,3 Alkalinization has been demonstrated to increase the duration of other blocks, including sciatic, 4 brachial plexus 5 and epidural blocks, 6 while other studies have found contradictory results. 7 In experiments using isolated nerve preparations, alkalinization of local anaesthetic solutions increases the efficacy of blocks and affording a higher concentration of anaesthetic at the nerve.S-12…”

Section: Improved Peribulbar Anaesthesia With Alkalinization and Hyalmentioning

confidence: 99%

Improved peribulbar anaesthesia with alkalinization and hyaluronidase

1993

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Comparison of Bupivacaine and Alkalinized Bupivacaine in Brachial Plexus Anesthesia

Cited by 27 publications

References 0 publications

A Comparative Study Between Bupivacaine with Adrenaline and Carbonated Bupivacaine with Adrenaline for Surgical Removal of Impacted Mandibular Third Molar

A Comparative Study Between Bupivacaine with Adrenaline and Carbonated Bupivacaine with Adrenaline for Surgical Removal of Impacted Mandibular Third Molar

Brachial plexus block with midazolam and bupivacaine improves analgesia

Improved peribulbar anaesthesia with alkalinization and hyaluronidase

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