Comparison of C-C motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery

CSA-AKI: Incidence, Epidemiology, Clinical Outcomes, and Economic Impact

“…Standardizing the definition of AKI into the KDIGO definition (and its predecessors) has advanced our understanding of AKI and improved epidemiologic AKI research. Newer biomarkers may be able to quickly and accurately diagnose kidney injury and specify patient phenotypes, including those whose AKI will persist (longer duration) or progress (worsen severity) [6][7][8][9]. There are growing calls for these biomarkers to be incorporated into routine clinical practice for use in risk stratification and diagnosis of AKI [10,11].…”

Towards a Better Crystal Ball: Urinary C-C Motif Chemokine Ligand 14 (CCL14) and Persistent Severe AKI

“…In this metric, CCL14 performed better than several frequently investigated biomarkers, including urinary neutrophil gelatinase-associated lipocalin, liver fatty acid binding protein, IL-18, tissue inhibitor of metalloproteinases-2, IGF-binding protein 7, kidney injury molecule-1, and plasma cystatin C. The performance of CCL14, however, was not statistically different from that of serum creatinine at the time of enrollment (AUC50.81; 95% CI, 0.76 to 0.86, P50.63). The association between CCL14 and AKI persistence has since been replicated in two additional studies with comparable predictive performance (21,22).…”

Urine Sediment Exam Provides More Diagnostic Information in AKI than Novel Urinary Biomarkers: CON

“…12 These findings were recently validated in a separate cohort of patients with severe AKI following cardiac surgery. 13 Novel biomarkers can provide valuable data in prognosticating which patients will progress from an AKI perspective, allowing for the identification of those destined for a rapid kidney recovery versus those who may benefit from measures to prevent progression to acute and chronic kidney disease.…”

“…Ashley La: Conceptualization; Writing -original draft Jay Koyner: Conceptualization; Writing -review and editing 13…”