Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients

Abstract

OBJECTIVE:The aim of this study was to evaluate and compare C-reactive protein and C-reactive protein-to-albumin ratio performances in predicting mortality of geriatric patients who visited the emergency department. METHODS:The data of patients with COVID-19 and aged 65 years and above, who visited emergency department during the study period, were retrospectively analyzed. The data were obtained from an electronic-based hospital information system. The area under the receiver operating characteristic curve and the area under the curve were used to assess each cutoff value discriminatory for predicting mortality. RESULTS:The mean age of the population included in this study was 76 (71-82) years, while 52.7% were males. The sensitivity, specificity, and area under the curve values for C-reactive protein in terms of mortality were calculated as 71.01, 52.34, and 0.635%, respectively, while the sensitivity, specificity, and area under the curve values for C-reactive protein-to-albumin ratio were calculated as 75.74, 47.66, and 0.645%, respectively (p<0.001). In the pairwise comparison for the receiver operating characteristic curves of C-reactive protein and C-reactive protein-to-albumin ratio, no statistically significant difference was found.CONCLUSIONS: Geriatric patients are the "most vulnerable" patient group against the COVID-19. In this study, both C-reactive protein and C-reactive protein-to-albumin ratio were found to be successful in predicting mortality for geriatric COVID-19 patients.

Comment on: “Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients”

“…A previous study explored the clinical relevance of the C-reactive protein-to-albumin (CRP/CAR) ratio for in-hospital mortality in patients with coronavirus disease 2019 (COVID-19) 2 . In this study, the findings revealed that both CRP and CRP/CAR ratio were effective in predicting mortality in elderly COVID-19 patients 1 . However, from our point of view, there are several issues that need to be addressed further in this investigation.…”

“…We read with interest the article entitled “Comparison of C-reactive protein and C-reactive protein-to-albumin ratio in predicting mortality among geriatric coronavirus disease 2019 patients.” 1 . A previous study explored the clinical relevance of the C-reactive protein-to-albumin (CRP/CAR) ratio for in-hospital mortality in patients with coronavirus disease 2019 (COVID-19) 2 .…”

Predictive power of HALP score in estimating short-term mortality in patients with acute pancreatitis

“…Therefore, serum albumin level would cause a reduction in inflammatory diseases. [18] In a multicenter study conducted with the data of 2461 AP patients, it was reported that mortality would increase more than 16 times if hypoalbuminemia was present in AP patients who admitted to the hospital. [19] The third variable of the HALP score, the lymphocyte, is a portion of the white blood cells.…”

The utility of hemoglobin, albumin, lymphocyte and platelet (HALP) score in predicting mortality among COVID-19 patients: a preliminary study

“…In the presence of nutritional problems, sepsis, severe trauma, malignancy, and severe inflammation, low albumin levels can be observed due to increased vascular permeability [15]. It has been shown that hypoalbuminemia is associated with mortality in critically ill patients [16]. In a study conducted in Italy, the data of 319 COVID-19 patients were examined, and when the patients were divided into survivor and nonsurvivor groups, the nonsurvivor group was determined to have lower albumin levels at the time of admission [17].…”