Comparison of Ca2+ channel inhibitory effects of cibenzoline with verapamil on guinea-pig heart

Matsuoka, Satoshi; Nawada, Takahiro; Hisatome, Ichiro; Miyamoto, Jiro; Hasegawa, Junichi; Kotake, Hiroshi; Mashiba, Hiroto

doi:10.1016/0306-3623(91)90314-v

Cited by 34 publications

(18 citation statements)

References 25 publications

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“…The data points in Fig. 4B lie close to a curve which describes the relationship between tension and ICa described by other groups in guinea-pig myocardium (Robertson & Lumley, 1989;Matsuoka et al 1991). It was noted that dextropropoxyphene and norpropoxythene reduced tension more than would be anticipated by a reduction of ICa as evidenced by the data points lying to the left of the curve in Fig.…”

Section: Discussionsupporting

confidence: 76%

“…The above experiments have shown that opioids and quinidine also attenuate ICa and the Ca2+ transient and it would be of value to investigate quantitatively the relationship between the dose dependency of their negative inotropic actions and their attenuation of either the Ca2+ transient or Ica Figure 4 shows such relationships between isometric twitch tension has been determined in guinea-pig myocardium using verapamil to modulate both variables (Robertson & Lumley, 1989;Matsuoka, Nawada, Hisatome, Miyamoto, Hasegawa, Kotake & Mashiba, 1991). In this case also, the attenuation of tension and ICa lie close to the estimated curve.…”

Section: Effects Of Drugs On the L-type Ca 2+ Channelsupporting

confidence: 53%

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The mode of action of several opioids on cardiac muscle

Wu¹,

Fry²,

Henry³

1997

Experimental Physiology

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SUMMARYThe objective of the experiments was to investigate the cellular basis of the inotropic effect on myocardium of several opioids which have been implicated in producing cardiotoxic effects in human poisioning. Opioids exerted negative inotropic effects, with half-maximal concentrations between 10 /LM (dextropropoxyphene) and 118 /,M (pethidine); all agents reduced the magnitude of the intracellular Ca2+ transient and the L-type Ca2+ current, ICa, over a similar concentration range to that which reduced twitch tension. The depression of ICa correlated positively with the value of the opioid oil-water partition coefficient. Effects were not antagonized by the opioid receptor antagonist naloxone. Action potential upstroke rate was also reduced but at significantly higher concentrations. Resting potential and action potential duration were not consistently affected; none of the opioids tested altered intracellular pH. These data suggest that opioids exert a negative inotropic effect by their action on ICa; blockade of the Na+ current is not great enough to exert a significant action. The lack of effect of naloxone implies the actions are independent of the opioid receptor. The correlation of effects with the oil-water partition coefficient implies a nonspecific effect dependent on the hydrophobicity of the agent.

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Section: Discussionsupporting

confidence: 76%

Section: Effects Of Drugs On the L-type Ca 2+ Channelsupporting

confidence: 53%

The mode of action of several opioids on cardiac muscle

Wu¹,

Fry²,

Henry³

1997

Experimental Physiology

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“…9,12 These effects were explained by that cibenzoline, a strong Na + channel-blocking agent, provoked a decrease of the intracellular Ca 2+ concentration in cardiac myocytes and exhibited Ca 2+ channel blocking activity. 12,13 Recently, in clinical case of SS with LVH due to HT, the satisfactory result of improving LVPG using cibenzoline in addition to metoprolol was demonstrated. 4 In our 2 cases without LVH, dual therapy with cibenzoline and atenolol obviously improved the LVPG caused by exercise in contrast to monotherapy with atenolol.…”

Section: Discussionmentioning

confidence: 99%

Effect of Cibenzoline and Atenolol Administration on Dynamic Left Ventricular Obstruction Due to Sigmoid-Shaped Septum

Ozaki

Sakuma

Mitsuma

et al. 2008

Circ J

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“…However, disopyramide has several adverse effects (including an anticholinergic effect). Hamada verapamil (2). During Na + influx, a focal increase in the Na + concentration could accelerate Ca 2+ influx via a reversal of Na + /Ca 2+ exchange.…”

Section: Discussionmentioning

confidence: 99%