Comparison of carbamazepine alone and in combination with baclofen in trigeminal neuralgia

Abstract

Introduction: Trigeminal neuralgia is a type of neuropathic facial pain that is characterized by unilateral paroxysmal pain that affects one or more trigeminal nerve divisions and is brought on by unimportant stimuli. People over the age of 40 are more likely to get it, and women are more frequently affected than males. Trigeminal neuralgia has been treated with a variety of drugs, including carbamazepine, oxcarbazepine, baclofen, lamotrigine, levetiracetam, gabapentin, sodium valproate, botulinum toxin-A injection, and surgical. OBJECTIVES: The current study's objective was to assess the efficacy of carbamazepine in treating trigeminal neuralgia in individuals both on its own and in combination with baclofen. METHODS: A randomized control trial was conductedat Khyber College of Dentistry and Peshawar Dental College among the patients of trigeminal neuralgia presenting to OPD. Total 60patients were randomly selected into two groups, each group had 30 patients.Carbamazepine was given to the Group A in the dose range of 300-600mg TDSwhereas, Carbamazepine 300mg TDS along with Baclofen in the dose range of 10-20 mg B.D was given to Group B. The two groups were given the drugs for a period of thirty days. The data was collected through a self-structuredquestionnaire.