Comparison of cardiac MRI with PET for assessment of myocardial viability in patients with coronary chronic total occlusion

Li, J.N.; He, Yi; Wang, Dong; Zhang, L.J.; Mi, Hongzhi; Zhang, D.F.; Huang, Rongchong; Song, Xiantao

doi:10.1016/j.crad.2019.01.021

Cited by 7 publications

(19 citation statements)

References 29 publications

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Section: Methodsmentioning

confidence: 99%

“…A total of 52 consecutive patients of IHD with reduced left ventricle ejection fraction (as assessed on echocardiography) and diagnosed with triple vessel disease with or without chronic total occlusion on catheter angiography were considered for revascularization surgery and were referred for viability assessment by 18 F-FDG PET. All these cases referred for 18 F-FDG PET were included in our study. Patients with history of myocardial infarction within 6 weeks before 18 F-FDG PET/MRI, those with contraindications to 18 F-FDG PET/MRI, and those with unstable angina and advanced heart failure (New York Heart Association Class IV) were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

“…All these cases referred for 18 F-FDG PET were included in our study. Patients with history of myocardial infarction within 6 weeks before 18 F-FDG PET/MRI, those with contraindications to 18 F-FDG PET/MRI, and those with unstable angina and advanced heart failure (New York Heart Association Class IV) were excluded from the study. The protocol was approved by the institutional ethics committee.…”

Section: Methodsmentioning

confidence: 99%

“…A total of 7 patients were excluded from the study due to various causes including non-compatible metallic implant (n = 02), deranged renal function (n = 02), and uncontrolled diabetes not suitable for 18 F-FDG PET(n = 3). All the patients underwent DCE-CMR and 18 F-FDG PET within a gap of 24-48 h of each other.…”

Section: Methodsmentioning

confidence: 99%

“…We have evaluated myocardial viability assessment by the proposed modified DCE-CMR protocol as compared to viable tissue defined by 18 flourodeoxy glucose positron emission tomography ( 18 F-FDG PET) in patients with IHD [6] as the nuclear imaging technique has been well validated as a reliable marker of myocardial viability.…”

Section: Introductionmentioning

confidence: 99%

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Myocardial viability imaging using a novel non-breath-hold cardiac MRI protocol: a comparative assessment with 18F-FDG PET

Aggarwal

Singla

Singh³

et al. 2020

Egypt J Radiol Nucl Med

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Background: Delayed contrast enhancement on cardiac magnetic resonance imaging is a well-established MRI technique for the evaluation of myocardial tissue viability. A comprehensive cardiac MRI protocol for myocardial viability comprises of multiple breath hold sequences to provide information regarding chamber volumes, myocardial mass, and function in addition to viability. However, its routine use is limited mainly by lengthy acquisition time and patient's inability to hold breath in multiple breath hold sequences. The important question to which the referring cardiologists/cardiac surgeons are seeking answer is that "What are the viable vascular territories that will benefit from revascularization?" In this study, we have analyzed the utility of non-breath-hold rapid delayed contrast-enhanced cardiac MR imaging protocol for myocardial viability assessment with 18-flourodeoxyglucose positron emission tomography (18 F-FDG PET) as the reference standard. Results: Forty patients of ischemic heart disease who met the inclusion criteria were included. All patients underwent both 18 F-FDG PET and delayed contrast-enhanced cardiac magnetic resonance imaging as per the non-breath-hold protocol. In this free-breathing protocol, the breath hold cine sequences were omitted and, after localizers, post-contrast scans were obtained with a time gap of 15 min post-contrast administration. A total number of 680 myocardial segments and corresponding 120 vascular territories were assessed. MRI and 18 F-FDG PET images were analyzed using a 17-segment model as proposed by AHA. Sensitivity, specificity, positive predictive value, and negative predictive value of non-breath-hold rapid delayed contrast-enhanced cardiac MR imaging protocol for assessing myocardial viability (on segment analysis) was 95.5%, 65.59%, 88.0%, and 84.72%, respectively, and of vascular territory analysis were 96.77%, 92.59%, 97.83%, and 89.29%, respectively, in relation to 18 F-FDG PET used as the reference standard. Spearman's rank correlation coefficient is 0.62. Conclusion: This modified non-breath-hold delayed contrast-enhanced cardiac MR imaging protocol is a reliable tool to answer the clinically relevant question of myocardial viability with a significant reduction in acquisition time and overcomes the limiting need of breath hold.

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Section: Methodsmentioning

confidence: 99%