Comparison of cardiometabolic risk biomarkers from a national clinical laboratory with the US adult population

Wolin, Elliott; White, Justin; Pottala, James V.; Sasinowski, Maciek; Dall, Tara; Dayspring, Thomas; McConnell, Joseph P.; Hoefner, Daniel M.; Varvel, Stephen A.; Thiselton, Dawn L.; Warnick, G. Russell; Harris, William S.

doi:10.1016/j.jacl.2015.07.014

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…However, previous studies in this specific cohort found that standard risk biomarkers (cholesterol, glucose, etc.) generally reflected those of typical adults living in the United States examined in Nutrition And Health Examination Surveys (NHANES) [70]. Also, O3I values were similar to those from a representative US sample [71], and RDW, MCV, and Hb were within normal ranges [7,72,73].…”

Section: Increases In Membrane Dha (A Highly Flexible Molecule) Influ...mentioning

confidence: 52%

Omega-3 index is directly associated with a healthy red blood cell distribution width

McBurney

Tintle

Harris

2022

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Section: Increases In Membrane Dha (A Highly Flexible Molecule) Influ...mentioning

confidence: 52%

Omega-3 index is directly associated with a healthy red blood cell distribution width

McBurney

Tintle

Harris

2022

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…However, a prior report comparing laboratory values with those obtained from the recent National Health and Nutrition Examination survey concluded that with some caveats, the referral laboratory patient population is likely to be generally representative of the US population. 31 Apo(a) isoforms were not measured in this study; therefore, we could not analyze their relationship to Lp(a) levels. Finally, data on concomitant statin therapy was not available.…”

Section: Limitationsmentioning

confidence: 99%

Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United States

Varvel

McConnell

Tsimikas

2016

ATVB

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Objective-Elevated lipoprotein(a) [Lp(a)] is a causal, independent risk factor for cardiovascular disease and aortic stenosis.We aimed to define the prevalence and patient thresholds of elevated Lp(a) levels in the United States. Approach and Results-We analyzed Lp(a) levels in 532 359 subjects from 2 data sets: (1) in 531 144 subjects from a referral laboratory and (2) in 915 patients from a tertiary referral center. Lp(a) mass levels were measured by immunoturbidometric assays in both centers and expressed as mg/dL. At the referral laboratory, the median age (interquartile range) of the subjects was 57.0 (46-67) years, and 51.9% were female. Lp(a) levels were skewed rightward as expected. The mean±SD levels were 34.0±40.0 mg/dL, and median (interquartile range) levels were 17 (7-47) mg/dL, with range 0 to 907 mg/dL. Lp(a) levels at 75%, 80%, 90%, 95%, 99%, and 99.9% percentiles were >47, >60, >90, >116, >180, and >245 mg/dL, respectively. At the referral laboratory, Lp(a) levels >30 and >50 mg/dL were present in 35.0% and 24.0% of subjects, respectively, and at the tertiary referral center, 39.5% and 29.2%, respectively. Females had higher mean (SD) (37. Results Data From the Referral LaboratoryRelationship of Lp(a) to Lipid, Lipoprotein, and High Sensitivity C-Reactive Protein Levels Over the 5-year period, a total of 531 144 Lp(a) measurements, with accompanying information on lipid parameters and high sensitivity C-reactive protein (hsCRP), from individual patients in the referral laboratory were available. The median age of all the subjects was 57.0 (46-67), 51.9% were female, and the mean body mass index was 29.7±6.7. Tables 1 and 2 display the relationship of Lp(a) mass, in quintiles and as Lp(a) <30 mg/dL versus >30 mg/dL and <50 mg/dL versus >50 mg/dL, to mean levels of LDL cholesterol (LDL-C), estimated LDL-C corrected for Lp(a) cholesterol, total cholesterol, high-density lipoprotein cholesterol, triglycerides, apoB-100, and non-high-density lipoprotein cholesterol. The mean±SD Lp(a) levels were 34.0±40.0 mg/dL and median (interquartile range) levels were 17 (7-47) mg/dL, with range 0 to 907 mg/ dL. Lp(a) levels at 75%, 80%, 90%, 95%, 99%, and 99.9% percentiles were >47, >60, >90, >116, >180, and >245 mg/dL, respectively. Females had higher mean (SD) (37. Lp(a) levels >30 and >50 mg/dL were present in 35.0% and 24.0% of subjects, respectively. Evaluating Lp(a) in quintiles, LDL-C linearly increased from 99.1 to 108.6 mg/dL. In contrast, removing the Lp(a) cholesterol component of Lp(a) showed that the corrected LDL-C was actually decreasing from 98.1 to 78.5 mg/dL with increasing Lp(a) mass. Total cholesterol, high-density lipoprotein cholesterol, apoAI, and non-high-density lipoprotein cholesterol were all increasing with increasing Lp(a), but triglycerides decreased across quintiles. hsCRP was also increasing linearly with Lp(a) quintiles or Lp(a) cutoffs of >30 and >50 mg/dL (Tables 1 and 2). Frequency Distribution of Lp(a), LDL-C, and ApoBAs expected, Lp(a) mass levels were skewed rightward (...

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“…However, previous studies in this specific cohort found that standard risk biomarkers (cholesterol, glucose, etc.) generally reflected those of typical adults living in the United States examined in Nutrition And Health Examination Surveys (NHANES) [66]. Also, O3I values were similar to those from a representative US sample [67], and RDW, MCV, and Hb were within normal ranges [7,68,69].…”

Section: Discussionmentioning

confidence: 77%

Omega-3 Index is Directly Associated with a Healthy Red Blood Cell Distribution Width

McBurney

Tintle

Harris

2021

Preprint

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Low red blood cell (RBC) membrane content of EPA and DHA, i.e., the omega-3 index (O3I), and elevated RBC distribution width (RDW) are risk factors for all-cause mortality. O3I and RDW are related with membrane fluidity and deformability. Our objective was to determine if there is a relationship between O3I and RDW in healthy adults. Subjects without inflammation or anemia, and with values for O3I, RDW, high-sensitivity C-reactive protein (CRP), body mass index (BMI), age and sex were identified (n=25,485) from a clinical laboratory dataset of >45,000 individuals. RDW was inversely associated with O3I before and after (both p<0.00001) adjusting models for sex, age, BMI and CRP. Stratification by sex revealed a sex-O3I interaction with the RDW-O3I slope (p<0.00066) being especially steep in females with O3I ≤5.6%. In healthy adults of both sexes, the data suggested that an O3I of >5.6% may help maintain normal RBC structural and functional integrity.

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Comparison of cardiometabolic risk biomarkers from a national clinical laboratory with the US adult population

Cited by 9 publications

References 25 publications

Omega-3 index is directly associated with a healthy red blood cell distribution width

Omega-3 index is directly associated with a healthy red blood cell distribution width

Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United States

Omega-3 Index is Directly Associated with a Healthy Red Blood Cell Distribution Width

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