Comparison of Cardiovascular, Analgesic and Sedative Effects of Different Doses of Dezocine

Abstract

Background: Dezocine is considered to be an alternative medication for managing postoperative pain. However, no study is focused on the cardiovascular, analgesic and sedative effects of intravenous Dezocine during anesthesia recovery period after micro vascular decompression (MVD) surgery for hemi facial spasm (HS).Therefore; we provide the clinical practice on this topic. Methods: A total of 160 patients, American Society of Anesthesiologists (ASA) physical status I-II, undergoing elective MVD surgery for HS, were randomized equally into four groups. The four groups were given intravenously a matching placebo (group A) (equal volume of 0.9% saline), Dezocine 0.05 mg/kg (group B), 0.1 mg/kg (group C) and 0.2 mg/kg (group D) respectively. Mean arterial pressure (MAP) and heart rate (HR) were measured at three periods: 5minutes before anesthesia induction (T0), at the moment of pulling out laryngeal mask (LMA) (T1),10 minutes after the procedure(T2).Sedation-Agitation Scale (SAS) at T1, Visual Analogue Scale (VAS) and Modified Observers Assessment of Alertness/Sedation Scale (OAA/S)at T2 were assessed in four groups. Mean while, the incidences of respiratory depression (RD), postoperative nausea and vomiting (PONV) were also observed during anesthesia recovery period in four groups. Multivariate analysis of variance and the Pearson χ2 test were used, and a value of P< 0.05 was considered statistically significant. Results: The mean value of anesthesia recovery time was higher in group D (P<0.05 vs. group A).It indicated statistical differences (P<0.05vs. group A) in SAS and VAS at T1 in group C and in group D, the value of OAA/S indicated statistical difference (P<0.05vs. group A) at T2 in group D. It indicated significant differences (P<0.05 vs. group A) in MAPand HR at