Comparison of Carotid Intima-Media Thickness in Patients With Stable Angina Pectoris Versus Patients With Acute Coronary Syndrome

Demircan, Şenol; Tekin, Abdullah; Tekin, Göknur; Topçu, Semra; Yiğit, Fatma; Erol, Tansel; Katırcıbaşı, Tuna; Sezgin, Alpay Turan; Baltalı, Mehmet; Özin, Bülent; Müderrisoğlu, Haldun

doi:10.1016/j.amjcard.2005.04.035

Cited by 17 publications

(22 citation statements)

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“…Using a logistic regression analysis with CIMT and the variables included in the TIMI risk score [6], only the age ≥65 [OR: 3.64 (CI: 1.45–9.14), p = 0.001] and diabetes mellitus [OR: 3.72 (1.57–8.80), p = 0.003] remained statistically significant predictors. Similarly, abnormal DPI was associated with age [OR: 19.38 (6.63–56.68), p < 0.001] and diabetes mellitus [OR: 2.89 (1.02–8.22), p = 0.047].…”

Section: Resultsmentioning

confidence: 99%

“…The values of the CIMT have been related to the presence of coronary atherosclerosis [2], classical cardiovascular risk factors [3], a higher risk of suffering an acute myocardial infarction [4] and more complex coronary or carotid lesions at angiography [5, 6]. Another ultrasonography-based technique is Doppler study of the intracranial arteries, which may reveal the presence of vascular dysfunction at this level, reflecting an ‘intracranial microangiopathy’ [7, 8].…”

Section: Introductionmentioning

confidence: 99%

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Common Carotid Artery Intima-Media Thickness and Intracranial Pulsatility Index in Non-ST-Elevation Acute Coronary Syndromes

Tello‐Montoliu

Moltò²,

López-Hernández³

et al. 2007

Cerebrovasc Dis

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Background: Common carotid intima-media thickness (CIMT) has been related to cardiovascular risk factors, coronary atherosclerosis and a higher risk of myocardial infarction. Evaluation of intracranial arteries by transcranial Doppler explores the presence of vascular dysfunction at this level. We tested the hypothesis that CIMT and Doppler Pulsatility Index (DPI) can be related to the Thrombolysis in Myocardial Infarction (TIMI) risk score for non-ST-elevation acute coronary syndrome (nST-ACS). The relation to the prognosis after an acute event was also assessed. Methods: We recruited 126 consecutive patients (80 males; mean age: 66.6 ± 13.1 years) admitted with nST-ACS. A carotid assessment with bidimensional mode, measuring the CIMT in the posterior wall of the common carotid artery, and a transcranial Doppler assessment of the middle cerebral artery, with measurement of the Pulsatility Index were carried out. Clinical follow-up at 6 months was performed for endpoints (cardiovascular death, recurrent ACS or revascularization). Results: Fifty-nine patients had an abnormal (≧0.8 mm) CIMT, whilst 70 patients had an abnormal DPI (≧1.2). CIMT was correlated with TIMI risk score (Pearson r: 0.26; p = 0.004), whilst abnormal DPI was associated with TIMI risk scale (p < 0.001). Using a logistic regression analysis, the presence of an abnormal CIMT was only related to age ≧65 (p = 0.0012) and diabetes mellitus (p = 0.0028). Abnormal DPI was also associated with age ≧65 (p < 0.0001) and diabetes mellitus (p = 0.0466). Neither CIMT nor DPI were related to 6 months’ clinical outcome. Conclusions: Patients with nST-ACS have a high prevalence of dates of abnormal DPI, which was associated with increased CIMT. Both variables were related to age and diabetes but not with clinical outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Common Carotid Artery Intima-Media Thickness and Intracranial Pulsatility Index in Non-ST-Elevation Acute Coronary Syndromes

Tello‐Montoliu

Moltò²,

López-Hernández³

et al. 2007

Cerebrovasc Dis

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“…Uma vez que a aterosclerose é uma doença sistêmica, a aterosclerose carotídea também pode refletir o desenvolvimento deste processo em artérias coronárias e vice-versa e a EMIC pode ser mais associada com a gravidade da SCA do que com a mortalidade (Demircan et al, 2005;Ciccone et al, 2013;Rosa et al, 2003). (Greenland et al, 2010).…”

Section: Emic Como Fator Preditor De Risco Cardiovascularunclassified

“…Pacientes com SCA tinham aumento significativo da EMIC em comparação com pacientes com angina estável (0,76 ± 0,10 vs0,70 ± 0,10 mm, P <0,05). Os valores de EIMC relatados neste estudo (Demircan et al, 2005) foram semelhantes aos encontrados em nosso estudo (valor Discussão -81 médio de 0,74 mm).…”

Section: Emic Como Fator Preditor De Risco Cardiovascularunclassified

“…Independentemente de diferenças na metodologia e características da amostra comparando estes estudos prévios (Held et al, 2001;Tello-Montoliu et al, 2007) com o nosso, sugere-se que não há nenhuma relação entre EMIC e mortalidade em pacientes pós-SCA. Algumas hipóteses que talvez justifiquem estes resultados nulos, incluindo aqueles apresentados no nosso estudo, deve ser devido a EMIC ser um melhor marcador de aterosclerose subclínica em estágios iniciais da doença coronariana e, portanto, é um preditor fraco de mortalidade neste grupo de pacientes, mesmo nos valores mais elevados em comparação com indivíduos com DAC mais estável (Demircan et al, 2005, Ciccone et al, 2013, Rosa et al, 2003.…”

Section: O Valor Prognóstico Da Emic Na Scaunclassified

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Valor prognóstico da espessura médio-intimal da artéria carótida na mortalidade de curto e longo prazo na estratégia de registro de síndrome coronariana aguda (ERICO)

Meireles¹

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Reducing risk of stroke in patients with acute coronary syndrome: is screening for asymptomatic carotid disease useful?

et al. 2008

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Stroke is a rare but severe event after acute coronary syndrome. Relations between both arterial territories are still discussed but prevalence of asymptomatic carotid stenosis potentially implicated in the mechanism of stroke is under-investigated. This study aimed to determine the prevalence of asymptomatic carotid stenosis in that population and review the value of screening in a view to potential surgical correction or other preventive therapies. Systematic carotid Doppler ultrasound screening was implemented on 152 consecutive patients admitted to the intensive care unit due to acute coronary syndrome. Fifty-two percent of patients had at least one carotid artery stenosis determined using the NASCET method. Forty-three percent had at least one carotid stenosis <30%, 6% had mild (30-60%) stenosis, and 2.6% had high-grade (>60%) stenosis. Existence of carotid stenosis was associated with age, diabetes mellitus, hypertension, and with the extent of the coronary atherosclerosis (left main artery stenosis). In multivariate analysis, age and diabetes were independently associated with existence of a carotid stenosis. When ultrasound screening was restricted to patients identified by multivariate analysis, the prevalence of carotid stenosis potentially requiring surgical treatment rose to 4.6%. The frequency of asymptomatic carotid atherosclerosis was high in this population but lesions were mild. While the small number of high-grade lesions indicates that systematic screening is not to be recommended, screening of patients aged >65 years or with diabetes, or both, with a view to surgery may be envisaged, since the role of mild stenosis in the occurrence of stroke remains debatable.

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Comparison of Carotid Intima-Media Thickness in Patients With Stable Angina Pectoris Versus Patients With Acute Coronary Syndrome

Cited by 17 publications

References 4 publications

Common Carotid Artery Intima-Media Thickness and Intracranial Pulsatility Index in Non-ST-Elevation Acute Coronary Syndromes

Common Carotid Artery Intima-Media Thickness and Intracranial Pulsatility Index in Non-ST-Elevation Acute Coronary Syndromes

Valor prognóstico da espessura médio-intimal da artéria carótida na mortalidade de curto e longo prazo na estratégia de registro de síndrome coronariana aguda (ERICO)

Reducing risk of stroke in patients with acute coronary syndrome: is screening for asymptomatic carotid disease useful?

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