Comparison of CD34+ cell collection on the CS‐3000+ and Amicus blood cell separators

Jeanne, Michel; Bouzgarrou, R; Lafarge, Xavier; Fizet, D; Dazey, Bernard; Vezon, G; Ivanović, Zoran

doi:10.1046/j.1537-2995.2003.00516.x

Cited by 26 publications

(36 citation statements)

References 9 publications

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“…This was confirmed by Jeanne et al [4], although this group reported a progressively decreasing CD34…”

Section: Discussionsupporting

confidence: 55%

“…1 cells was reported superior [4] and comparable to the COBE Spectra [5,6]. The platelet contamination was lower than in other systems [4][5][6].…”

Section: Introductionsupporting

confidence: 52%

“…The platelet contamination was lower than in other systems [4][5][6]. In patients with high WBC precounts, the CE for CD34 1 cells was lower than in those with precounts < 40 G/l.…”

Section: Introductionmentioning

confidence: 64%

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Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children

Witt

Beiglböck

Ritter

et al. 2007

J of Clinical Apheresis

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The AMICUS system was recently introduced for peripheral blood stem cell (PBSC) aphereses in adults. We conducted a single center field evaluation to obtain data about the performance of this system in children with a body weight (bw) < 25 kg. Results of blood priming procedures were compared to historical data obtained with the Fenwal CS3000+ (CS 3000). From August, 2001 to February, 2007, 47/178 (26%) PBSC aphereses procedures were performed in our institution with the AMICUS system in 35 small patients (median bw 13.9 kg; range 6.7-24; age 2.78 years; range 0.97-7.06). The patients suffered from various malignant primary diseases or recurrences. We primed the system with packed RBC in case of >30% dilution of the RBC volume (n = 31) or with saline (n = 16). Compared to the CS3000, the AMICUS revealed comparable collection efficiencies (CE) for CD34+ cells (median 67%, range 26-120), lymphocytes (75%, 25-138), monocytes (54%, 23-173), and granulocytes (10%, 1.5-36), MNC (57% 24-125), but a significantly higher erythrocyte and granulocyte, and a lower platelet CE. There was a significant negative correlation between total leukocyte count and CE for MNC (r = -0.566; P < 0.001) and CD34+ cells (r = -0.517; P < 0.001). There was no significant statistical or clinical difference between the CE in blood-primed procedures and saline-primed procedures. With the AMICUS we saw statistically less citrate reactions compared to the CS 3000. We conclude that the AMICUS system is safe and efficient to harvest PBSC on a routine basis in pediatric patients, even in children < or =10 kg bw.

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“…This was confirmed by Jeanne et al [4], although this group reported a progressively decreasing CD34…”

Section: Discussionsupporting

confidence: 55%

“…1 cells was reported superior [4] and comparable to the COBE Spectra [5,6]. The platelet contamination was lower than in other systems [4][5][6].…”

Section: Introductionsupporting

confidence: 52%

See 1 more Smart Citation

Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children

Witt

Beiglböck

Ritter

et al. 2007

J of Clinical Apheresis

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“…Our modified protocol significantly improved mononuclear and CD34 + cell harvest compared to the manufacturer's protocol. Under our modified procedure, we routinely collected 5 × 10 6 CD34 + cells per kg, which is equivalent to numbers in human trials published in the literature [13,25,28,31]. Thus, with our modified protocol, it is possible to collect sufficient numbers of CD34 + stem cells for various applications including transplantation experiments in monkeys.…”

Section: Discussionmentioning

confidence: 99%

“…of leukapheresis for adults [10,13,25,28] and children [1,8,15,31], only one very limited trial has been conducted on a human newborn baby [32]. To our knowledge, this paper is the first systematic documentation of leukapheresis for small primates.…”

mentioning

confidence: 98%

Safe And Efficient Collection of Cytokine-Mobilized Peripheral Blood Cells From Cynomolgus Monkeys (Macaca fascicularis) with Human Newborn-Equivalent Body Weights

et al. 2005

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Comparison of spectra optia and amicus cell separators for autologous peripheral blood stem cell collection

Chung

Kong

et al. 2020

J of Clinical Apheresis

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Introduction: Autologous peripheral blood stem cell (PBSC) transplantation has become a standard treatment option for many oncology patients. The aim of this study was to evaluate the performance of two cell separators, Spectra Optia (Terumo BCT, Japan) and Amicus (Fresenius-Kabi) for autologous PBSC collection. Methods: We retrospectively evaluated 56 apheresis by Spectra Optia with Continuous Mononuclear Cell Collection (cMNC) from 20 patients, and 50 apheresis by Amicus from 27 patients between December 2018 and December 2019. CD34+ collection efficiency (CE2) and platelet (PLT) loss were evaluated. Results: There was no significant difference in CD34+ CE2 between Spectra Optia with cMNC (median, 28.8%) and Amicus (median, 33.1%; P = 0.537). PLT loss was significantly lower in Amicus (median, 28.6%) than in Spectra Optia with cMNC (median, 37.8%; P = 0.009). Conclusion: CD34+ CE2 was comparable between Spectra Optia and Amicus, and PLT loss was significantly lower in Amicus. To the best of our knowledge, this is the first report comparing autologous PBSC collection of the Spectra Optia and Amicus. These results may provide general guidance with regard to device selection to apheresis clinics that use both separators for optimal outcomes depending on each patient's characteristics.

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Comparison of CD34+ cell collection on the CS‐3000+ and Amicus blood cell separators

Cited by 26 publications

References 9 publications

Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children

Performance of a new separator system for routine autologous hematopoietic progenitor cell collection in small children

Safe And Efficient Collection of Cytokine-Mobilized Peripheral Blood Cells From Cynomolgus Monkeys (Macaca fascicularis) with Human Newborn-Equivalent Body Weights

Comparison of spectra optia and amicus cell separators for autologous peripheral blood stem cell collection

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