Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue

Gingras, Marie Claude; Roussel, Eugène; Bruner, Janet M.; Branch, Cynthia D.; Moser, Richard P.

doi:10.1016/0165-5728(94)00178-q

Cited by 171 publications

(123 citation statements)

References 53 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…More recently, tumour cells have also been recognised to synthesise avb3 (Chen et al, 1997). A possible link between its expression therein and tumour progression and/or invasiveness has been suggested for melanomas, glioblastomas and cancers of the breast, stomach and cervix (Albelda et al, 1990;Pignatelli et al, 1992;Gingras et al, 1995;Kawahara et al, 1995;Chattopadhyay and Chatterjee, 2001).…”

Section: Discussionmentioning

confidence: 99%

Correlation between the tumoral expression of β3-integrin and outcome in cervical cancer patients who had undergone radiotherapy

et al. 2004

View full text Add to dashboard Cite

Integrins are cell-surface receptors, which mediate cell-to-cell and cell-to-extracellular matrix adhesion. Besides playing an important role in tumour angiogenesis, b3-integrin is also expressed in several types of epithelial cancer cells. It was the purpose of the present study to evaluate the prognostic value of b3-integrin expression in patients with cervical cancer. Biopsies were taken from 82 patients with squamous cell or adenocarcinomas of the uterine cervix who had undergone external-beam radiotherapy with or without brachytherapy. These tissue samples were analysed immunohistochemically for the expression of b3-integrin. The impact of immunoreactivity for b3-integrin on survival end points was assessed by univariate and multivariate analyses, and its correlation with clinicopathological characteristics evaluated by crosstabulations. b3-integrin was expressed in 61% (50 of 82) of the patients. KaplanMeier curves revealed local progression-free survival, distant metastasis-free survival and cause-specific survival to be significantly shorter (P-values according to the log-rank test: 0.002, 0.04 and 0.01, respectively) in patients with b3-integrin expression. The prognostic impact of this parameter was even higher than for other well-known prognostic parameters and remained statistically significant in the multivariate analyses. b3-integrin, which is expressed in the majority of patients with advanced cervical cancer, has a significant prognostic impact on outcome according to univariate and multivariate analyses.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation between the tumoral expression of β3-integrin and outcome in cervical cancer patients who had undergone radiotherapy

et al. 2004

View full text Add to dashboard Cite

show abstract

“…This adhesion points give cells a polarity which enable them to move forward. In GBM, integrin β1 is overexpressed and is associated with migration (76,77). Integrin a9β1 expression correlates with glioma grade and influences MMP-9 expression (78,79).…”

Section: Integrins-the Link Between the Ecm And Cellsmentioning

confidence: 99%

Molecular Mechanisms of Glioma Cell Motility

et al. 2017

View full text Add to dashboard Cite

Gliomas are the most common intracranial tumors in humans. The most malignant among these tumors is glioblastoma (GBM), with an incidence of 3-5 out of 100,000 persons in Western countries. GBM arises either de novo (primary GBM) or develops from a lower grade glioma (secondary GBM). The prognosis is poor. GBMs are lethal tumors and even optimal surgical resection, followed by chemotherapy and irradiation, results in a median survival of about 12-15 months. One characteristic that is responsible for GBM malignancy, and its worse prognosis, is the highly infiltrative growth of GBM cells into the healthy brain. GBM cell migration and invasion is a very complex process that is regulated by several factors, which include changes in the migrating cell itself as well as the tumor microenvironment. This chapter provides an overview of routes of invasion of glioma cells, the signaling pathways that drive glioma cell motility, and the processes through which glioma cells modulate their surrounding environment.

show abstract

“…Based on our observation that Lyn but not Fyn is necessary for the PDGF-stimulated migration of glioblastoma cells when integrin a v h 3 is engaged (8) and the known up-regulation of the PDGFr and integrin a v h 3 in these tumors (18)(19)(20)(21)(22)(23), we compared the levels of Lyn kinase activity, protein, and message in glioblastoma (grade IV) tumor biopsy samples with those in anaplastic astrocytoma (grade III) tumor samples, nonneoplastic brain, and normal autopsy brain samples. We found that Lyn kinase activity is significantly elevated in the glioblastoma biopsy samples.…”

Section: Introductionmentioning

confidence: 99%

Lyn Kinase Activity Is the Predominant Cellular Src Kinase Activity in Glioblastoma Tumor Cells

Stettner¹,

Wang²,

Nabors

et al. 2005

Cancer Research

102

View full text Add to dashboard Cite

Cellular Src activity modulates cell migration, proliferation, and differentiation, and recent reports suggest that individual members of the Src family may play specific roles in these processes. As we have found that Lyn, but not Fyn, activity promotes migration of glioblastoma cells in response to the cooperative signal generated by platelet-derived growth factor receptor B and integrin A v B 3 , we compared the activity and expression of Lyn and Fyn in glioblastoma (grade IV) tumor biopsy samples with that in anaplastic astrocytoma (grade III) tumors, nonneoplastic brain, and normal autopsy brain samples. Lyn kinase activity was significantly elevated in glioblastoma tumor samples. Notably, the Lyn kinase activity accounted for >90% of pan-Src kinase activity in glioblastoma samples but only %30% of pan-Src kinase activity in the other groups. The levels of phosphorylation of the autophosphorylation site were consistent with significantly higher Lyn activity in glioblastoma tumor tissue than nonneoplastic brain. Although the normalized levels of Lyn protein and the relative levels of Lyn message were significantly higher in glioblastoma samples than nonneoplastic brain, the normalized levels of Lyn protein did not correlate with Lyn activity in the glioblastoma samples. There was no significant difference in the normalized levels of c-Src and Fyn protein and message in the glioblastoma and nonneoplastic brain. Immunostaining revealed that Lyn is located primarily in the glioblastoma cells in the tumor biopsies. These data indicate that Lyn kinase activity is significantly elevated in glioblastoma tumors and suggest that it is the Lyn activity that promotes the malignant phenotype in these tumors. (Cancer Res 2005; 65(13): 5535-43)

show abstract

Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue

Cited by 171 publications

References 53 publications

Correlation between the tumoral expression of β3-integrin and outcome in cervical cancer patients who had undergone radiotherapy

Correlation between the tumoral expression of β3-integrin and outcome in cervical cancer patients who had undergone radiotherapy

Molecular Mechanisms of Glioma Cell Motility

Lyn Kinase Activity Is the Predominant Cellular Src Kinase Activity in Glioblastoma Tumor Cells

Contact Info

Product

Resources

About