Comparison of central sensitization-related symptoms and health-related quality of life between breast cancer survivors with and without chronic pain and healthy controls

Manfuku, Masahiro; Nishigami, Tomohiko; Mibu, Akira; Tanaka, Katsuyoshi; Kitagaki, Kazufumi; Sumiyoshi, Kazuhiro

doi:10.1007/s12282-019-00979-y

Cited by 26 publications

(26 citation statements)

References 39 publications

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“…The anticipated pain narrows one's ability to assimilate threat-related cues and increases pain intensity, resulting in both activity intolerance and emotional distress [16,17]. In breast cancer surgery, regardless of the possible presence of persistent post-surgical pain, no differences in treatment-or disease-related variables have been observed [18,19]. However, differences in PC are identified as one of the key-mechanisms of the fear-avoidance model contributing to the development of persistent pain complaints [17,20,21].…”

mentioning

confidence: 99%

The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors

Leysen

Cools

Nijs

et al. 2021

Support Care Cancer

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confidence: 99%

The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors

Leysen

Cools

Nijs

et al. 2021

Support Care Cancer

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“…In addition, other studies associate pain-related factors (i.e., pain intensity, presence of hyperalgesia, and widespread pain) throughout the treatment periods with higher CSI scores [ 51 ]. Our findings, therefore, suggest a potential relationship between the implementation of more treatment procedures and an increase in symptoms of central sensitization as measured with the CSI [ 16 , 21 ].…”

Section: Discussionmentioning

confidence: 98%

“…Pain persists in many women with breast cancer after treatment, possibly due to the sensitization of the central and peripheral nervous systems. Pain sensitization has been shown to be strongly associated with pain catastrophizing [ 21 ] and the persistent presence of pain to previous cancer treatment [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Pain Sensitivity in Treatment for Breast Cancer: A 12-Month Follow-Up Case Series

Lorenzo-Gallego

Arranz-Martín

Romay‐Barrero

et al. 2022

IJERPH

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This study aimed to investigate changes in the pain sensory profile of women with breast cancer. Five women with unilateral breast cancer were enrolled. Participants were assessed with direct (quantitative sensory testing, QST) and indirect measures of pain sensitization (self-reported central sensitization inventory, CSI) at baseline (before surgery), 1 week after surgery, and at 1, 6, 9, and 12 months post-surgery. In the event of pain occurrence, the Leeds Assessment of Neuropathic Symptoms and Signs was also used. Nociceptive pain was the predominant pain mechanism in the postoperative period, while an increase in sensitization predominated one year after breast cancer surgery, especially in those participants who had received more treatment procedures. The participants who received more therapies for breast cancer experienced persistent pain and a higher level of sensitization. An assessment protocol including direct measurements (QST) and indirect measurement (self-reported CSI) allows for detecting changes in pain sensitivity, which can be useful for characterizing and/or predicting pain before, during, and up to one year following surgical interventions for breast cancer.

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“…Age at surgery and time since surgery were continuous variables. These factors were determined based on risk factors for CPSP reported in previous studies [5,6,11,[23][24][25][26][27]. We also included the distribution of postsurgical pain regions, CARS-J total score, and BPI-PI total score in the univariate analyses, as these factors may affect the presence of CPSP and the need for CPSP treatment.…”

Section: Statistical Analysesmentioning

confidence: 99%

Predictive factors for patients who need treatment for chronic post-surgical pain (CPSP) after breast cancer surgery

et al. 2021

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Purpose: Although chronic postsurgical pain (CPSP) after breast cancer surgery is a common and prevalent postsurgical adverse event, the need for CPSP treatment has not been investigated. This study examined the proportion of patients who needed treatment for CPSP and associated predictors.Methods: We conducted a cross-sectional study with female patients who underwent breast cancer surgery at our institution. Participants were aged ≤65 years at the time of this study and were at least 1 year post surgery. The questionnaire examined the presence of and need for treatment for CPSP and included the Japanese version of the Concerns about Recurrence Scale (CARS-J). Multivariate analyses were used to identify independent predictors of needing treatment for CPSP.Results: In total, 305 patients completed the questionnaire. The mean time since surgery was 67.1 months; 151 (51%) patients developed CPSP after breast cancer surgery and 61 (39%) needed treatment for CPSP. Among patients that developed CPSP, the fear of breast cancer recurrence as assessed by the CARS-J (odds ratio [OR] 2.22, 95% con dence interval [CI]: 1.30-3.81, P=0.004) and >2 postsurgical pain regions (OR 2.52, 95% CI: 1.16-5.57, P=0.020) were independent predictors of needing treatment for CPSP.Conclusions: This study is the rst to identify the proportion and predictors of patients who need treatment for CPSP. Fear of breast cancer recurrence and >2 postsurgical pain regions may predict the need for CPSP treatment among patients following breast cancer surgery.

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Comparison of central sensitization-related symptoms and health-related quality of life between breast cancer survivors with and without chronic pain and healthy controls

Cited by 26 publications

References 39 publications

The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors

The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors

Changes in Pain Sensitivity in Treatment for Breast Cancer: A 12-Month Follow-Up Case Series

Predictive factors for patients who need treatment for chronic post-surgical pain (CPSP) after breast cancer surgery

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