Comparison of cerebellomedullary and lumbar cerebrospinal fluid analysis in dogs with neurological disease

Lampe, R.; Foss, Kari D.; Vitale, Samantha; Hague, Devon W.; Barger, Anne M.

doi:10.1111/jvim.15700

Cited by 12 publications

(24 citation statements)

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“…A comparison of paired CSF samples collected from CM and lumbar cisternae in neurologic dogs revealed that in patients with thoracolumbar myelopathies, CSF from the lumbar cisterna was significantly more likely to yield an abnormal result 10 . These findings agree with another study that evaluated CSF‐CK concentrations in samples collected from CM and lumbar cisternae in dogs with thoracolumbar IVDD 17 .…”

Section: Brief Communicationsupporting

confidence: 83%

“…However, in the clinical setting, the selection of sites for collection are often influenced by other factors, such as preference and experience of the clinician, patient safety, or body conformation 8 . A comparison of CSF analytes collected from both the CM and lumbar cisterna has indicated that in patients with lesions localizing to the thoracolumbar spine, CSF from the CM cisterna is likely to yield false‐negative results 10 . However, multiple studies evaluating biomarkers in CSF as prognostic factors in dogs with thoracolumbar disease only evaluated CSF from the CM cisterna 2,11‐13 .…”

Section: Brief Communicationmentioning

confidence: 99%

“…Ten dogs were prospectively recruited that were presented to the University of Illinois Neurology & Neurosurgery service in which a CSF analysis was recommended. Participants were a subset of patients recruited for a larger study 10 . To be enrolled in the study, dogs were required to have magnetic resonance imaging performed before the CSF collection.…”

Section: Brief Communicationmentioning

confidence: 99%

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Comparison of creatine kinase in cerebrospinal fluid collected from the cerebellomedullary and lumbar cisterna in 10 dogs with neurologic disease

Lampe

Foss

Hague

et al. 2020

Veterinary Clinical Pathol

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Background: Analysis of cerebrospinal fluid CK (CSF-CK) might be useful as a prognostic indicator in dogs with neurologic disease. Previous studies have mostly analyzed CSF-CK collected from the cerebellomedullary (CM) cisterna, but CSF collection sites could affect its levels. Objectives: This is a pilot study aimed to evaluate differences in CSF-CK concentrations when collected from the CM or lumbar cisterna in dogs presenting with neurologic disease. Methods: Ten dogs presenting for neurologic disease underwent magnetic resonance imaging and CSF collection from both the CM and lumbar cisterna. Cerebrospinal fluid CK was analyzed within 30 minutes. Results: Ten dogs were prospectively recruited. Overall, there was no statistically significant difference between CSF-CK collected from the CM or lumbar cisterna (P = .31). When evaluated by neurolocalization, CSF-CK was different between sites in dogs with thoracolumbar myelopathy (P = .024), but not in dogs with intracranial or cervical neurolocalization (P = .93). All dogs with thoracolumbar myelopathy had equivocal or higher CK levels at the lumbar collection site compared with levels at the CM collection site. Conclusions: Cerebrospinal fluid CK values differed depending on the CSF site collection, especially in dogs with thoracolumbar myelopathy. In dogs with thoracolumbar myelopathy, CSF-CK was likely to be higher when CSF was taken from the lumbar cisterna compared with the CM cisterna. Collecting CSF from the thoracolumbar site could provide better prognostic information than if collected at the CM collection site.

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Section: Brief Communicationsupporting

confidence: 83%

Section: Brief Communicationmentioning

confidence: 99%

Section: Brief Communicationmentioning

confidence: 99%

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Comparison of creatine kinase in cerebrospinal fluid collected from the cerebellomedullary and lumbar cisterna in 10 dogs with neurologic disease

Lampe

Foss

Hague

et al. 2020

Veterinary Clinical Pathol

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“…Recent studies have highlighted the potential clinical benefit of collecting both CMC and LSS CSF samples. [24][25][26] More specifically, Carletti et al 24 studied a population of 111 dogs diagnosed with SRMA with paired CSF samples (CMC and LSS). In eight of 111 patients, only one of the two samples had an increased TNCC.…”

Section: Discussionmentioning

confidence: 99%

“…A discrepancy on the clinicopathological conclusion between the two samples was observed in one case, where only the CMC sample was diagnostic of SRMA. Recent studies have highlighted the potential clinical benefit of collecting both CMC and LSS CSF samples 24–26 . More specifically, Carletti et al 24 studied a population of 111 dogs diagnosed with SRMA with paired CSF samples (CMC and LSS).…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid analysis in dogs: Main patterns and prevalence of albuminocytological dissociation

2021

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Background: Albuminocytological dissociation (ACD) of the cerebrospinal fluid (CSF) is defined as an increased total protein concentration with normal total nucleated cell count. It is suspected to occur in diseases that alter the blood-brain barrier, increase the production of protein or obstruct the flow of CSF. The purposes of this study were to review the CSF analysis results of a large cohort of dogs with neurological conditions, to analyse the total prevalence of ACD and to describe which diseases have a higher prevalence of ACD. Study design and methods: Medical records were retrospectively searched for dogs whom CSF was sampled from 2012-2019. Data collected included signalment, body weight, site of collection of the CSF, CSF analysis results, and final diagnosis. Results: A total of 497 dogs met the inclusion criteria. ACD was identified in 16.5% (82/497) of dogs. The diseases with higher proportion of ACD were cranial nerve neuropathy (6/10; 60.0%), brain tumour (10/24; 41.7%), idiopathic vestibular disease (7/17; 41.2%) and brain vascular disease (4/13; 30.8%). Clinical significance: This study describes the CSF patterns of the most common neurological conditions in dogs, also characterizing, for the first time in dogs, the prevalence and causes of ACD, which was identified in 16.5 % of the samples. The diseases with highest proportions of ACD were cranial nerve neuropathy, brain tumour, idiopathic vestibular disease and brain vascular disease.

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Complications associated with cerebrospinal fluid collection in dogs

et al. 2023

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BackgroundThis study aimed to identify complications associated with cerebrospinal fluid (CSF) collection in dogs.MethodsThis was a prospective, observational multicentre study using data collected from 102 dogs undergoing CSF collection for the investigation of neurological disease. CSF was collected from the cerebellomedullary cistern (CMC), lumbar subarachnoid space (LSAS) or both sites. Pre‐, intra‐ and postprocedural data were collected. Descriptive statistics were performed to outline complications associated with CSF collection.ResultsCSF sampling was attempted on 108 occasions, and CSF was acquired on 100 occasions (92.6%). Collection from the CMC was more likely to be successful than that from the LSAS. No dogs exhibited neurologic deterioration following CSF collection. There was no significant difference between pre‐ and post‐CSF collection short‐form Glasgow composite measure pain scores in ambulatory dogs (p = 0.13).LimitationsThe scarcity of complications limited the ability to quantify the incidence of some potential complications reported elsewhere.ConclusionsOur results may be used to inform clinicians and owners that CSF sampling is associated with a low frequency of complications when performed by trained personnel.

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Comparison of cerebellomedullary and lumbar cerebrospinal fluid analysis in dogs with neurological disease

Cited by 12 publications

References 11 publications

Comparison of creatine kinase in cerebrospinal fluid collected from the cerebellomedullary and lumbar cisterna in 10 dogs with neurologic disease

Comparison of creatine kinase in cerebrospinal fluid collected from the cerebellomedullary and lumbar cisterna in 10 dogs with neurologic disease

Cerebrospinal fluid analysis in dogs: Main patterns and prevalence of albuminocytological dissociation

Complications associated with cerebrospinal fluid collection in dogs

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