Comparison of cerebrospinal fluid monoamine metabolite levels in dominant-aggressive and non-aggressive dogs

Reisner, Ilana R.; Mann, J. John; Stanley, Michael; Huang, Yung‐yu; Houpt, Katherine A.

doi:10.1016/0006-8993(95)01464-0

Cited by 111 publications

(59 citation statements)

References 51 publications

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“…In dogs, reduced monoaminergic levels in cerebro-spinal fluid (CSF) may be associated with aggressive behaviour and impaired impulse control in aggressive contexts [1], and serotonin and dopamine related genes have been associated with aggression and impulsivity [4], [45], [46]. These findings support the idea that trait impulsivity in dogs has a similar biological basis to other species.…”

Section: Accepted M Manuscriptmentioning

confidence: 74%

“…Yet even if this idea is correct, a relationship between the metabolite levels and performance in the delayed reward task might be expected, as serotonin raises behavioural thresholds, and this would be reflected in their performance in such a task. It is important to note however, that whilst there is a long history of the measurement of neurotransmitters and their metabolites in blood, CSF and urine in a range of species [1], [30], [43], [49], the potential influence of the renal system on CNS levels remains unclear. Additional limitations in this study exist due to incomplete data resulting from unidentifiable chromatogram peaks following HPLC analysis.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…In dogs, "impulsivity" or "impulse control" is often mentioned in the context of aggressive behaviour ( [1], [2], [3], [4]). These studies describe "impulsive aggression," which has been defined as "aggressive behaviours occurring with reduced or absent warning signals" [2], and draw similarities with the human literature on impulse control [3], [4], without prior consideration of whether the trait exists, or is expressed in the same way in dogs.…”

Section: Introductionmentioning

confidence: 99%

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Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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Impulsivity is a trait related to inhibitory control which is expressed in a range of behaviours. Impulsive individuals show a decreased ability to tolerate delay of reinforcement, and more impulsive behaviour has been linked to decreased levels of serotonin and dopamine in a number of species. In domestic dogs, impulsivity is implicated in problem behaviours that result from a lack of self control, but currently there are no published studies that assess behavioural and physiological measures of impulsivity in relation to this trait. Impulsivity scores were calculated for 41 dogs using an owner-report assessment, the Dog Impulsivity Assessment Scale (DIAS).Twenty-three of these subjects completed an operant choice task based on a delayed reward paradigm, to assess their tolerance to delay of reinforcement. High Pressure Liquid Chromatography (HPLC) with Fluorometric Detection was used to detect levels of the metabolites of serotonin (5-HIAA) and dopamine (HVA) in the urine of 17 of the subjects. Higher impulsivity scores were found to be significantly correlated with more impulsive behaviour (reduced tolerance to delay of reinforcement) in the behaviour tests and lower levels of urinary 5-HIAA and 5-HIAA/HVA ratio. The results demonstrate convergent validity between impulsivity (as assessed by the DIAS) and behavioural and physiological parameters.

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Section: Accepted M Manuscriptmentioning

confidence: 74%

Section: Accepted M Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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“…Correlations among behavioral problems and neurotransmitters, especially plasma and platelet concentrations of serotonin, dopamine and norepinephrine have also been found in some species such as rats, rabbits, humans, and dogs (Rogeness et al, 1992;Higley et al, 1992Higley et al, , 1996Reisner et al, 1996;Reisner, 2002). There is additional evidence via the molecular methods used to manipulate the genes that control aggressive behavior and identify allelic variations, which may help to explain the differences in phenotype.…”

Section: Disscussionmentioning

confidence: 96%

Correlation analysis between single nucleotide polymorphism of DRD1 gene and stereotyped behavior of blue fox

Liu¹,

Ren²,

Ba³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study was performed to investigate the correlation between stereotyped behavior of the blue fox and single nucleotide polymorphisms (SNPs) of the DRD1 gene. We choose the DRD1 gene as a major gene for investigating the correlation of gene polymorphism and self-biting disease by means of direct sequencing. Part of the DRD1 gene exon of the blue fox was cloned; the length of the whole sequence was 864 bp. Four SNPs were detected and analyzed by the chi-square analysis; the results showed that the gene polymorphism of T206C in the DRD1 gene had a significant correlation with self-biting (P < 0.01). Therefore, marker-assistant selection on self-biting of blue foxes using these SNPs can be applied to select healthy individuals.

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“…These brain regions are thought to be involved in the control of emotional states, including aggression [8]. Moreover, low levels of homovanillic acid (HVA), a metabolite of dopamine, in the cerebrospinal fluid was reported in dogs that had exhibited severe impulsive aggression [11]. Based upon these findings, it appears reasonable to speculate that some breed-specific behavioral traits can be ascribed, at least in part, to certain SNPs, including the one in the MAOB gene described in the present study.…”

mentioning

confidence: 99%

Identification of an Cysteine-to-Arginine Substitution Caused by a Single Nucleotide Polymorphism in the Canine Monoamine Oxidase B Gene

Hashizume

Masuda

Momozawa

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. Monoamine oxidase B catalytically oxidizes biogenic amines such as phenylethylamine and dopamine, and its activity is presumed to be related to particular behavioral traits. In this study, we first identified a single nucleotide polymorphism (T199C) located on the putative third exon of the canine monoamine oxidase B gene, which causes an amino acid substitution from cysteine to arginine. We then examined the allelic frequencies in five dog breeds (Golden Retriever, Labrador Retriever, Maltese, Miniature Schnauzer, and Shiba) and found significant variation among them. The present results suggest that analysis of the monoamine oxidase B polymorphism could be a useful means of elucidating the genetic background of breed-specific behavioral characteristics in dogs. KEY WORDS: canine, MAOB, polymorphism.J. Vet. Med. Sci. 67(2): 199-201, 2005 Canine monoamine oxidase B (MAOB) is a pivotal enzyme that catalytically oxidizes monoamines in both the brain and peripheral tissues. In the canine brain, MAOB is located mainly in the hypothalamus and hippocampus [6]. In human studies, relationships between low levels of platelet MAOB activity and particular personality traits such as sensation-seeking, monotony avoidance, impulsiveness, and aggression have been reported [3,7,10].A single nucleotide polymorphism (SNP) located on intron 13 of the human MAOB gene was reported to be associated with MAOB activity in both the brain [1] and platelets [2]. In this study, we investigated the entire region of MAOB complementary DNA (cDNA) in an attempt to identify SNPs in the canine MAOB gene. Then, the identified SNP was examined for its genetic diversity among five canine breeds (Golden Retriever, Labrador Retriever, Maltese, Miniature Schnauzer, and Shiba) by genotyping its allelic frequencies.In order to search for any polymorphic site that might be present in the MAOB gene (GenBank accession: AB070958), we first amplified the nucleotide sequence for the whole amino acid coding region of the MAOB gene, using the brain cDNA of eleven Beagles as the template; to this end, RT-PCR was carried out according to a method we described in a previous report [6]. DNA sequencing was performed with the BigDye Terminator Cycle Sequencing FS Ready Reaction Kit using the ABI PRISM 377 DNA sequencer (Perkin-Elmer, U.S.A.). In order to assess genetic variation in the putative polymorphic region, blood cell samples were obtained from 210 individuals of the 5 dog breeds (46 Labrador Retrievers, 57 Golden Retrievers, 35 Malteses, 27 Miniature Schnauzers, and 45 Shibas). These blood samples were taken with the owners' consent during regular health checks in veterinary clinics. Genomic DNA was extracted with the QIAamp Blood Midi Kit (QIAGEN, U.S.A.), dissolved into H 2 O, and stored at 4°C until PCR was performed. To amplify the region containing the identified SNP (T199C), oligonucleotide primers for PCR were designed. The sequence of the forward primer was 5'-TCCATGGATACACCTCAAGG-3', and the reverse primer was 5'-TGATGGATGAGACGCTCTAC-3'....

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Comparison of cerebrospinal fluid monoamine metabolite levels in dominant-aggressive and non-aggressive dogs

Cited by 111 publications

References 51 publications

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Correlation analysis between single nucleotide polymorphism of DRD1 gene and stereotyped behavior of blue fox

Identification of an Cysteine-to-Arginine Substitution Caused by a Single Nucleotide Polymorphism in the Canine Monoamine Oxidase B Gene

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