2020
DOI: 10.1002/nau.24454
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Comparison of cernitin pollen extract vs tadalafil therapy for refractory chronic prostatitis/chronic pelvic pain syndrome: A randomized, prospective study

Abstract: Aims To compare the efficacy of cernitin pollen extract (cernitin) or tadalafil for treating persistent chronic pelvic pain despite α1‐blocker monotherapy in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and lower urinary tract symptoms (LUTS). Methods A total of 100 patients with refractory CP/CPPS despite ongoing α1‐blocker monotherapy were randomized to receive add‐on therapy with either cernitin (4 capsules/day) or tadalafil (5 mg/d) for 12 weeks. At week 12, changes from baseline in … Show more

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Cited by 8 publications
(16 citation statements)
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“…Clinically, there are few studies discussing its role in CP/CPPS. Unfortunately, most of these studies either lacked control arm or run in BPH associated CP/CPPS or in combination with other medications [19][20][21].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Clinically, there are few studies discussing its role in CP/CPPS. Unfortunately, most of these studies either lacked control arm or run in BPH associated CP/CPPS or in combination with other medications [19][20][21].…”
Section: Discussionmentioning
confidence: 99%
“…Clinically; few limited studies had investigated the outcome of PDE5-inhibitors in management of CP/CPPS, unfortunately, these studies mostly lacked control arm [19][20][21][22]. In this placebo-controlled clinical trial we aimed to evaluate the results of tadalafil treatment alone in management of non BPH-related CP/CPP patients.…”
Section: Introductionmentioning
confidence: 99%
“…As a consequence of an aging society, the number of men complaining of LUTS induced by BPE is increasing. In clinical practice, some patients complain not only of LUTS but also of chronic pelvic pain or discomfort, such as prostatitis‐like symptoms 1,2 . Prostatitis syndromes are classified into the infectious type (acute and chronic), chronic pelvic pain type, or asymptomatic type 1 .…”
Section: Introductionmentioning
confidence: 99%
“…In clinical practice, some patients complain not only of LUTS but also of chronic pelvic pain or discomfort, such as prostatitis-like symptoms. 1,2 Prostatitis syndromes are classified into the infectious type (acute and chronic), chronic pelvic pain type, or asymptomatic type. 1 Among these, CP/CPPS, which is classified as category III prostatitis by the United States National Institutes of Health, has the highest frequency (>90% of men with prostatitis) and is often refractory to treatment.…”
Section: Introductionmentioning
confidence: 99%
“…More recently in a randomized clinical trial, Matsukawa et al [ 17 ] evaluated the effect of a 3-month treatment with pollen extract (n. 42 men) or tadalafil (n. 45 men) in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and lower urinary tract symptoms (LUTS). In this study, the authors documented that both pollen extract and tadalafil significantly improved chronic pelvic pain, even if the pollen extract was more effective than tadalafil in the improvement of pelvic pain and discomfort.…”
Section: Introductionmentioning
confidence: 99%