Comparison of change in end tidal carbon dioxide after three minutes of step exercise between systemic sclerosis patients with and without pulmonary hypertension

Bernstein, Elana J.; Gordon, Jessica; Spiera, Robert; Huang, Wei-Ti; Horn, Evelyn M.; Mandl, Lisa A.

doi:10.1093/rheumatology/kew365

Cited by 3 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This non-invasive sub-maximum test has been previously shown to differentiate PAH patients from healthy controls 16 and help in the diagnosis of systemic sclerosis-associated PH. 14,15 It consists of a portable unit with a 14 cm high step that patients step up and down for three minutes. The unit is equipped with a portable metabolic cart and a mouthpiece that is connected to a continuous gas exchange analyzer.…”

Section: Methodsmentioning

confidence: 99%

“…12 More recently, sub-maximum CPET has garnered increasing attention in the diagnostic evaluation of patients with PH. [13][14][15][16] Unlike conventional CPET, a maximum exercise effort is not required, making it an attractive option for patients with cardio-pulmonary or musculoskeletal disorders and elderly patients who often are unable to undergo maximum exercise testing. While previous research have examined the diagnostic utility of sub-maximum CPET in PH, these initial studies were limited to patients with pulmonary arterial hypertension (PAH) only.…”

Section: Introductionmentioning

confidence: 99%

“…While previous research have examined the diagnostic utility of sub-maximum CPET in PH, these initial studies were limited to patients with pulmonary arterial hypertension (PAH) only. [14][15][16] Recently, Klaassen et al, showed that an abnormal ventilatory efficiency (VE/VCO 2 ) in HFpEF patients during sub-maximum CPET is associated with greater PVR and increased mortality. 13 However, the diagnostic utility of sub-maximum gas exchange parameters to help distinguish Ipc-PH and Cpc-PH remains unknown.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction

et al. 2020

View full text Add to dashboard Cite

Background: Pulmonary hypertension (PH) is commonly associated with heart failure with preserved ejection fraction (HFpEF). In HFpEF, the elevated left sided filling pressures results in isolated post-capillary PH (Ipc-PH) or combined pre- and post-capillary PH (Cpc-PH). Although right heart catheterization (RHC) is the gold standard for diagnosis, it is an invasive test with associated risks. Echocardiogram on the other hand does not help distinguish between Ipc-PH and Cpc-PH. The ability of sub-maximum cardiopulmonary exercise test (CPET) as an adjunct diagnostic tool in PH associated HFpEF is not known. Methods: 46 patients with HFpEF and PH (27 patients with Cpc-PH and 19 patients with Ipc-PH) underwent sub-maximum CPET followed by RHC. The study also included 18 age and gender matched control subjects. Several sub-maximum gas exchange parameters were examined to determine the ability of sub-maximum CPET to distinguish between Ipc-PH and Cpc-PH. Results: Echocardiogram did not distinguish between Ipc-PH and Cpc-PH. Compared to Ipc-PH, Cpc-PH had greater ventilatory equivalent for carbon dioxide (VE/VCO2) slope, reduced delta end-tidal CO2 change during exercise, reduced oxygen uptake efficiency slope (OUES), and reduced gas exchange determined pulmonary vascular capacitance (GXCAP). The latter was significantly associated with RHC determined pulmonary artery compliance (r=0.5; p=0.0004). Conclusion: Sub-maximum gas exchange parameters obtained during CPET in an ambulatory setting allows for discrimination between Ipc-PH and Cpc-PH. Sub-maximum CPET may be a useful end-point measure in HFpEF population.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Kots S.M. (2017). Kharakterystyka variabelnosti sertsevoho rytmu u molodykh liudei z riznym rivnem rukhovoi aktyvnosti.…”

Section: Theoreticalunclassified

Proceedings of the XXVII International Scientific and Practical Conference

2023

View full text Add to dashboard Cite

Kots S.M., Kots V.P., Kots V.V. The work presents the topic of influence of environmental factors on the human body, preservation of health, avoidance of dangerous conditions, classification of types of reactions to weather changes is presented. Weather changes cause hormonal and physiological changes in all body systems. The risk group of weather-dependent conditions includes pregnant women, the elderly, young children, overweight people, patients with diseases of the cardiovascular system, endocrine diseases, and patients with diseases of the nervous system. Being informed will make it possible to avoid the occurrence of exacerbations and diseases when weather factors affect a sensitive person.Keywords. Meteorological sensitivity, cardiovascular system, preservation of health.Introduction. Any weather changes cause hormonal and physiological changes in all body systems. We considered some aspects of weather sensitivity earlier [1, 2]. Cardiovascular and respiratory systems react very actively to weather factors. If you add fear, worries, negative emotions, which are enough in the modern life of Ukrainians, a high level of anxiety, anxiety, depressive states, reduced work capacity, self-harm [5][6][7][8][9][10][11][12][13][14], all this can affect the state of the immune system, organs, and body systems. study of the functional state of the cardiovascular system is now relevant [17][18][19][20][21][22][23][24][25][26].Purpose: to analyze information on the impact of weather conditions and factors on the body and recommendations for alleviating negative consequences.Main part. Doctors make it possible for themselves to evade a concrete quantitative ascertainment answer and often say that, in fact, everyone is weather-

show abstract

Cellular and Molecular Diversity in Scleroderma

Hinchcliff

García-Milián²,

Donato³

et al. 2021

Seminars in Immunology

View full text Add to dashboard Cite

Comparison of change in end tidal carbon dioxide after three minutes of step exercise between systemic sclerosis patients with and without pulmonary hypertension

Abstract: [Formula: see text] and [Formula: see text] as measured by the step test are statistically significantly different between SSc patients with and without PH. [Formula: see text] and [Formula: see text] may be useful screening tools for PH in the SSc population.

Cited by 3 publications

References 32 publications

Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction

Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction

Proceedings of the XXVII International Scientific and Practical Conference

Cellular and Molecular Diversity in Scleroderma

Contact Info

Product

Resources

About