Comparison of changes in endothelial cell count and central corneal thickness after phacoemulsification and small-incision cataract surgery

Kumar, Ram; Wahi, Dipti; Tripathi, Punita

doi:10.4103/ijo.ijo_1906_22

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…A little endothelial injury following surgery might also result in a transient increase in corneal thickness. 7 Endothelial cell density and central corneal thickness can be assessed clinically using specular microscopy. 8 The most frequent reason for poor vision recovery after surgery is macular edoema, which is caused by cataract surgery.…”

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confidence: 99%

A comparative study of central macular thickness and endothelial cell changes in patients with diabetes mellitus undergoing phacoemulsification.

Kulkarni,

Thool

2023

F1000Res

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One of the most prevalent causes of blindness worldwide is cataracts. Along with the lens, Diabetes mellitus can impact all ocular structures. Diabetics have a higher incidence of cataract formation due to a variety of reasons. Diabetic people may have thicker corneas. The most frequent reason for poor vision recovery after surgery is macular edema, which is caused by cataract surgery. Therefore, after phacoemulsification, we are measuring the central macular thickness and central corneal thickness in diabetics in order to observe the post phacoemulsification macular edema and any significant changes in corneal thickness. We expect a morphological changes in endothelial cells, increase central corneal thickness and increase central macular thickness post-operatively after uncomplicated phacoemulsification surgery.

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Section: Introductionmentioning

confidence: 99%

A comparative study of central macular thickness and endothelial cell changes in patients with diabetes mellitus undergoing phacoemulsification.

Kulkarni,

Thool

2023

F1000Res

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Examination of the Corneal Endothelium in Patients With Congenital Aniridia With a PAX6 Mutation Using In Vivo Confocal Laser Scanning Microscopy

Csidey,

Csorba,

Kormányos

et al. 2024

Cornea

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Purpose: In PAX6 syndrome, it is still not clear, whether prenatally, parallel to the iris tissue developmental anomaly, there is neural ectodermal, neural crest, or mesodermal cell deposition at the corneal endothelium, affecting endothelial structure and function. In addition, because of the postnatal corneal inflammation and commonly appearing secondary glaucoma, progressive endothelial changes are expected. Our purpose was to study the corneal endothelium in subjects with PAX6 aniridia, using in vivo confocal laser scanning microscopy. Methods: Twenty-seven eyes of 16 subjects with congenital aniridia (age 28.25 ± 16.32 [11–59] years, 8 [50%] female) and 40 eyes of 26 healthy subjects (age 33.8 ± 15.2 [14–67] years, 17 [58.6%] females) were examined. Aniridia-associated keratopathy and iris malformation were graded, and means of endothelial cell density, cell area, cell diameter, spatial pattern of cell centroids (Clark–Evans index), polygonality, neighbor count, percentage of hexagonal cells, and endothelial deposit number were determined by in vivo confocal laser scanning microscopy. Results: Mean cell diameter and mean Clark–Evans index were significantly lower (P = 0.049; P = 0.008) in congenital aniridia eyes than in controls. There were hyperreflective endothelial deposits in congenital aniridia eyes but not in controls (P < 0.001). Only aniridia-associated keratopathy grade correlated positively with mean endothelial deposit number (P = 0.017). Conclusions: In congenital aniridia, the corneal endothelium might possess a slightly better quality and greater reserves than in healthy subjects. Corneal endothelial deposition seems to be independent from developmental abnormalities but may be related to up to date undescribed endothelial inflammatory or metabolic changes.

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Comparative analysis of central corneal thickness and macular thickness changes following phacoemulsification and small incision cataract surgery: A prospective study

Singh,

Sharma,

Maurya

et al. 2024

IJCEO

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To quantify the changes in central corneal thickness and macular thickness after uncomplicated cataract surgery and to compare its outcomes in terms of visual acuity. : A total of 81 patients with senile cataract who were scheduled for either Phacoemulsification or SICS surgery were included in this study. They were divided into two groups: 41 patients underwent Phacoemulsification and 40 patients underwent SICS. CCT and CMT were measured with optical coherence tomography (OCT) preoperatively and postoperatively at Day 1, day 7, week 6 and 3 months.: Preoperative baseline measurements showed no significant difference in CCT and MT between the two groups (p > 0.05). Central corneal thickness showed significant differences between the two groups at different postoperative time points at day 1 and day 7. Central macular thickness also showed significant differences at day 7 and 6 week, with the SICS group showing consistently higher macular thickness values compared to the Phacoemulsification group from day 1 to 3 months after surgery. This suggested that the type of cataract surgery may have had an impact on retinal thickness outcomes, with more pronounced and permanent changes occurring in the SICS group. In addition, both group A (SICS) and group B (Phacoemulsification) showed good visual outcomes, with comparable improvements in BCVA.: Our results suggested that both SICS and Phacoemulsification techniques are effective in improving visual acuity, but SICS may result in more pronounced retinal changes while faster resolution of macular thickness was seen in phacoemulsification. Both groups also exhibited transient subclinical changes in CCT following cataract surgery. However, these changes were generally reversible, and early recovery occurred after phacoemulsification. The visual acuity was improved after both procedures but phacoemulsification surgery showed slightly better visual outcomes. Understanding these differences may help to adjust postoperative treatment strategies to optimize outcomes for patients undergoing cataract surgery.

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Comparison of changes in endothelial cell count and central corneal thickness after phacoemulsification and small-incision cataract surgery

Cited by 4 publications

References 18 publications

A comparative study of central macular thickness and endothelial cell changes in patients with diabetes mellitus undergoing phacoemulsification.

A comparative study of central macular thickness and endothelial cell changes in patients with diabetes mellitus undergoing phacoemulsification.

Examination of the Corneal Endothelium in Patients With Congenital Aniridia With a PAX6 Mutation Using In Vivo Confocal Laser Scanning Microscopy

Comparative analysis of central corneal thickness and macular thickness changes following phacoemulsification and small incision cataract surgery: A prospective study

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