Comparison of Characteristics and Survival of Colorectal Cancer Between Japanese-Americans in Hawaii and Native Japanese in Japan

Sakamoto, Kazuhiro; Machi, Junji; Prygrocki, Maria; Watanabe, Tomoo; Hosoda, Seiji; Shimada, Masahiko; Tomiki, Yuichi; Kamano, Toshiki

doi:10.1007/s10350-005-0211-9

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…Recently, the incidence of colon cancer in Japan has been increasing 27. In addition, CRC occurs more frequently in the proximal colon and less frequently in the rectum among the Japanese–American population in Hawaii compared to native Japanese in Japan 28. These facts suggest that different genetic and environmental factors contribute to the pathogenesis of rectal, distal and proximal colon cancer, respectively.…”

Section: Discussionmentioning

confidence: 99%

Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population

Cui

Okada

Jang

et al. 2011

Gut

145

109

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Background and aimColorectal cancer (CRC) is a multifactorial disease with both environmental and genetic factors contributing to its development. The incidence of CRC is increasing year by year in Japan. Patients with CRC in advanced stages have a poor prognosis, but detection of CRC at earlier stages can improve clinical outcome. Therefore, identification of epidemiologial factors that influence development of CRC would facilitate the prevention or early detection of disease.MethodsTo identify loci associated with CRC risk, we performed a genome-wide association study (GWAS) for CRC and sub-analyses by tumour location using 1583 Japanese CRC cases and 1898 controls. Subsequently, we conducted replication analyses using a total of 4809 CRC cases and 2973 controls including 225 Korean subjects with distal colon cancer and 377 controls.ResultsWe identified a novel locus on 6q26-q27 region (rs7758229 in SLC22A3, p=7.92×10−9, OR of 1.28) that was significantly associated with distal colon cancer. We also replicated the association between CRC and SNPs on 8q24 (rs6983267 and rs7837328, p=1.51×10−8 and 7.44×10−8, ORs of 1.18 and 1.17, respectively). Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.ConclusionsWe found a novel susceptible locus in SLC22A3 that contributes to the risk of distal colon cancer in an Asian population. These findings would further extend our understanding of the role of common genetic variants in the aetiology of CRC.

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Section: Discussionmentioning

confidence: 99%

Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population

Cui

Okada

Jang

et al. 2011

Gut

145

109

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“…Similarly, patients and tumor characteristics of JA or NJ have been changing to those of American people. Sakamoto et al [10] investigated whether characteristics, prognostic risk factors, and survival of CRC of JA in Hawaii are different from those of NJ in Japan from 1996 to 2002, and reported that there are no remarkable differences in prognostic factors and survival between the two groups. Kotake et al [11] reported that male patients of NJ with CRC have remarkably increased.…”

Section: Discussionmentioning

confidence: 97%

Improvement of long-term survival of colorectal cancer in Japanese-Americans of Hawaii from 1990 to 2001

et al. 2010

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“…This tendency is consistent with the results of the hierarchical cluster analysis. However, a comparison of patient characteristics was made between the 1,129 Japanese patients with colorectal cancer in our study and the data from 30,002 patients who were registered with the Japanese Society for Cancer of the Colon and Rectum between 1993 and 1997 ( 41 ), as well as the data from 621 patients who were registered in a single institution in Japan between 1992 and 2002 ( 42 ). This comparison revealed that, although age, gender, tumor location and histology had generally similar distributions, the percentages of T1/2, N0 and stage I/II were clearly low, and as a whole, the stage of cancer tended to be more advanced in our study.…”

Section: Discussionmentioning

confidence: 99%

Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis

Shimamoto

Nukatsuka

Takechi

et al. 2015

International Journal of Molecular Medicine

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To establish the individualized treatment of patients with colorectal cancer, factors associated with chemotherapeutic effects should be identified. However, to the best of our knowledge, few studies are available on this topic, although it is known that the prognosis of patients and sensitivity to chemotherapy depend on the location of the tumor and that the tumor location is important for individualized treatment. In this study, primary tumors obtained from 1,129 patients with colorectal cancer were used to measure the mRNA expression levels of the following genes associated with the effects of standard chemotherapy for colorectal cancer: 5-fluorouracil (5-FU)-related thymidylate synthase (TYMS), dihydropyrimidine dehydrogenase (DPYD) and thymidine phosphorylase (TYMP); folate-related dihydrofolate reductase (DHFR), folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH); irinotecan-related topoisomerase I (TOP1); oxaliplatin-related excision repair cross-complementing 1 (ERCC1); biologic agent-related vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR). Large-scale population analysis was performed to determine the association of gene expression with the clinicopathological features, in particular, the location of the colorectal cancer. From the results of our analysis of the mRNA expression of these 10 genes, we noted the strongest correlation between DPYD and TYMP, followed by TYMS and DHFR. The location of the colorectal cancer was classified into 4 regions (the right- and left-sided colon, rectosigmoid and rectum) and was compared with gene expression. A significant difference in all genes, apart from VEGF, was noted. Of the remaining 9 genes, the highest expression of TYMS and DPYD was observed in the right-sided colon; the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum, and higher than that in other locations. The data generated from this study may prove to be useful for the development of individualized chemotherapeutic treatments for patients with colorectal cancer, and will mean that the tumor location is taken into account.

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Comparison of Characteristics and Survival of Colorectal Cancer Between Japanese-Americans in Hawaii and Native Japanese in Japan

Cited by 7 publications

References 22 publications

Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population

Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population

Improvement of long-term survival of colorectal cancer in Japanese-Americans of Hawaii from 1990 to 2001

Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis

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