Comparison of Child-Turcotte-Pugh and Pediatric End-Stage Liver Disease Scoring Systems to Predict Morbidity and Mortality of Children Awaiting Liver Transplantation

Dehghani, Seyed Mohsen; Gholami, S.; Bahador, Abbas; Haghighat, Mahmood; Imanieh, Mohammad Hadi; Nikeghbalian, Saman; Salahi, H; Davari, Hamid Reza; Mehrabani, Davood; Malek-Hosseini, S.A.

doi:10.1016/j.transproceed.2007.07.080

Cited by 18 publications

(21 citation statements)

References 15 publications

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“…The developers of the PELD score did not consider the presence of ascites as a prognostic factor,12 probably because of the difficulty in establishing objective parameters for measuring it. On the other hand, 1 study showed a fair correlation between the Child‐Turcotte‐Pugh scoring system and the PELD score 19…”

Section: Discussionmentioning

confidence: 97%

Four hundred thirty consecutive pediatric living donor liver transplants: Variables associated with posttransplant patient and graft survival

et al. 2012

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The availability of living donors allows transplant teams to indicate living donor liver transplantation (LDLT) early in the course of liver disease before the occurrence of life-threatening complications. Late referral to transplant centers is still a problem and can compromise the success of the procedure. The aim of this study was to examine the perioperative factors associated with patient and graft survival for 430 consecutive pediatric LDLT procedures at Sirio-Libanes Hospital/A. C. Camargo Hospital (Sã o Paulo, Brazil) between October 1995 and April 2011. The studied pretransplant variables included the following: recipient age and body weight, Pediatric End-Stage Liver Disease score, z score for height/age, bilirubin, albumin, international normalized ratio, hemoglobin, sodium, presence of ascites, and previous surgery. The analyzed technical aspects included the graft-to-recipient weight ratio and the use of vascular grafts for portal vein reconstruction. In addition, the occurrence of hepatic artery thrombosis (HAT), portal vein thrombosis (PVT), and biliary complications was also analyzed. The liver grafts included 348 left lateral segments, 5 monosegments, 51 left lobes, and 9 right lobes. In a univariate analysis, an age < 12 months, a low body weight ( 10 kg), malnutrition, hyperbilirubinemia, and HAT were associated with decreased patient and graft survival after LDLT. In a multivariate analysis, a body weight 10 kg and HAT were significantly associated with decreased patient and graft survival. The use of vascular grafts significantly increased the occurrence of PVT. In conclusion, a low body weight ( 10 kg) and the occurrence of HAT independently determined worse patient and graft survival in this large cohort of pediatric LDLT patients.

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Section: Discussionmentioning

confidence: 97%

Four hundred thirty consecutive pediatric living donor liver transplants: Variables associated with posttransplant patient and graft survival

et al. 2012

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“…Biochemical parameters (LFT, haemogram, prothrombin time), chest radiography, arterial blood gas (ABG) and contrast‐enhanced echocardiography were done in all children at enrolment. Paediatric end‐stage liver disease (PELD) , Child–Turcotte–Pugh score (CTP) scores were calculated in children with cirrhosis.…”

Section: Methodsmentioning

confidence: 99%

Hepatopulmonary Syndrome in children: a comparative study of non‐cirrhotic vs. cirrhotic portal hypertension

Borkar

Poddar

Kapoor

et al. 2014

Liver International

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“…The Child-Pugh score has long been used to assess the severity of liver disease [33]. More recently PELD and growth failure have been shown to reflect the potential for morbidity and mortality in this cohort of patients more accurately [34]. In a study on 63 patients who had Kasai portoenterostomy for BA, PELD scores ≥ 15 and age at operation ≥ 60 days were shown as at significant risk factors for liver failure (P value =0.001) [35].…”

Section: Discussionmentioning

confidence: 99%

Surviving Sengstaken

Jayakumar¹,

Odulaja²,

Patel³

et al. 2015

Journal of Pediatric Surgery

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Comparison of Child-Turcotte-Pugh and Pediatric End-Stage Liver Disease Scoring Systems to Predict Morbidity and Mortality of Children Awaiting Liver Transplantation

Cited by 18 publications

References 15 publications

Four hundred thirty consecutive pediatric living donor liver transplants: Variables associated with posttransplant patient and graft survival

Four hundred thirty consecutive pediatric living donor liver transplants: Variables associated with posttransplant patient and graft survival

Hepatopulmonary Syndrome in children: a comparative study of non‐cirrhotic vs. cirrhotic portal hypertension

Surviving Sengstaken

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