Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA

Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes

“…11 However, the results were not altered when using this definition in PIAMA or when analyzing TEW as the outcome, which is one of the previously identified and validated phenotypes from longitudinal latent class analysis in PIAMA (data not shown). 44 In the analyses on TEW we have excluded children with symptoms of wheeze at school age (5.6% with late onset and 11.4% with persistent wheeze in PIAMA), an outcome known to be closely related to asthma and allergic sensitization. 11 A challenge to directly assess relationships between COPD genes, early lung function deficits, and COPD is to overcome the long time period between early childhood events and COPD onset.…”

Update on the utility of corticosteroids in acute pediatric respiratory disorders

“…20 -22 Given the multitude of patterns of early childhood wheezing, with their differing pathophysiologies and natural histories, 23,24 clinical trials that have evaluated corticosteroid response in this age group have included mixed populations of children with wheezing, both singlewheezing-episode and recurrent wheezing. In addition, many trials are comprised of populations that could be appropriately classified as experiencing episodic wheeze, whereas others may include those with both episodic wheeze and diagnosed asthma.…”

Monitoring asthma in childhood

“…With the varying clinical presentation of asthma through childhood there is increasing focus on trying to identify new types of asthma phenotypes or endotypes for future individual targeted management [18][19][20]. Several phenotypes of asthma have been described and identified, which are commonly based on the time of presentation of "wheeze" within the first part of childhood [21]. In addition, phenotypes based on the presence or absence of allergic sensitisation, eosinophilic or noneosinophilic inflammation, response to treatment, asthma severity or allergic disease comorbidities are recognised [22][23][24][25][26].…”