Comparison of chiral electrophoretic separation methods for phenethylamines and application on impurity analysis

Borst, Claudia; Holzgrabe, Ulrike

doi:10.1016/j.jpba.2010.06.025

Cited by 32 publications

(19 citation statements)

References 34 publications

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“…In addition, dynamically coated capillaries runs allows for shorter analysis times and improved migration time reproducibility [22,23].…”

Section: Page 6 Of 36mentioning

confidence: 99%

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Regioisomeric and enantiomeric analyses of 24 designer cathinones and phenethylamines using ultra high performance liquid chromatography and capillary electrophoresis with added cyclodextrins

Li¹,

Lurie²

2015

Forensic Science International

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“…In addition, dynamically coated capillaries runs allows for shorter analysis times and improved migration time reproducibility [22,23].…”

Section: Page 6 Of 36mentioning

confidence: 99%

“…In contrast, CE with the addition of chiral CDs has been successfully employed for analyses of various drugs, including amphetamines and cathinones [35][36][37][38][39][40][41].…”

Section: Page 7 Of 36mentioning

confidence: 99%

Regioisomeric and enantiomeric analyses of 24 designer cathinones and phenethylamines using ultra high performance liquid chromatography and capillary electrophoresis with added cyclodextrins

Li¹,

Lurie²

2015

Forensic Science International

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“…1-phenylethanol (two-electron reduction) is the main product of this reduction, and thus of much interest to the fine chemical, pharmaceutical and cosmetic industries [11][12][13][14][15].…”

Section: Page 3 Of 20mentioning

confidence: 99%

Electrocatalytic hydrogenation of acetophenone using a Polymer Electrolyte Membrane Electrochemical Reactor

Sáez

García-García

Solla-Gullón

et al. 2013

Electrochimica Acta

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Please cite this article as: A. Sáez, V. García-García, J. Solla-Gullón, A. Aldaz, V. Montiel, Electrocatalytic hydrogenation of acetophenone using a Polymer Electrolyte Membrane Electrochemical Reactor, Electrochimica Acta (2010Acta ( ), doi:10.1016Acta ( /j.electacta.2012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 20 A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 AbstractThe use of a solid polymeric electrolyte, spe, is not commonly found in organic electrosynthesis despite its inherent advantages such as the possible elimination of the electrolyte entailing simpler purification processes, a smaller sized reactor and lower energetic costs. In order to test if it were possible to use a spe in industrial organic electrosynthesis, we studied the synthesis of 1-phenylethanol through the electrochemical hydrogenation of acetophenone using Pd/C 30% wt with different loadings as cathode and a hydrogen gas diffusion anode. A Polymer ElectrolyteMembrane Electrochemical Reactor, PEMER, with a fuel cell structure was chosen to carry out electrochemical reduction with a view to simplifying an industrial scale-up of the electrochemical process. We studied the influence of current density and cathode catalyst loading on this electroorganic synthesis. Selectivity for 1-phenylethanol was around 90% with only ethylbenzene and hydrogen detected as by-products.

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“…with cyclodextrines as chiral selectors represents an elegant and effective method for a baseline enantioseparation (e.g. Borst and Holzgrabe, 2010 and literature cited herein).…”

Section: Enantiomeric Puritymentioning

confidence: 99%

Ficts and facts of epinephrine and norepinephrine stability in injectable solutions

Hoellein

Holzgrabe

2012

International Journal of Pharmaceutics

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Comparison of chiral electrophoretic separation methods for phenethylamines and application on impurity analysis

Cited by 32 publications

References 34 publications

Regioisomeric and enantiomeric analyses of 24 designer cathinones and phenethylamines using ultra high performance liquid chromatography and capillary electrophoresis with added cyclodextrins

Regioisomeric and enantiomeric analyses of 24 designer cathinones and phenethylamines using ultra high performance liquid chromatography and capillary electrophoresis with added cyclodextrins

Electrocatalytic hydrogenation of acetophenone using a Polymer Electrolyte Membrane Electrochemical Reactor

Ficts and facts of epinephrine and norepinephrine stability in injectable solutions

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