2019
DOI: 10.3390/pharmaceutics11120655
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Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

Abstract: Posidonia oceanica (L.) Delile is a marine plant endemic of Mediterranean Sea endowed with interesting bioactivities. The hydroalcholic extract of P. oceanica leaves (POE), rich in polyphenols and carbohydrates, has been shown to inhibit human cancer cell migration. Neuroblastoma is a common childhood extracranial solid tumor with high rate of invasiveness. Novel therapeutics loaded into nanocarriers may be used to target the migratory and metastatic ability of neuroblastoma. Our goal was to improve both the a… Show more

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Cited by 25 publications
(28 citation statements)
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References 47 publications
(89 reference statements)
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“…The wound-healing assay was used to evaluated SH-SY5Y cell migration into the wounded area [ 39 , 66 , 67 ]. Cells were seeded in 6-well plate at the density of 5 x10 5 cells/well in complete medium and were let to grow until a confluence monolayer was reached.…”
Section: Methodsmentioning
confidence: 99%
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“…The wound-healing assay was used to evaluated SH-SY5Y cell migration into the wounded area [ 39 , 66 , 67 ]. Cells were seeded in 6-well plate at the density of 5 x10 5 cells/well in complete medium and were let to grow until a confluence monolayer was reached.…”
Section: Methodsmentioning
confidence: 99%
“…It has a low critical micelle concentration (CMC) and its micelles are highly stable after dilution [ 34 , 35 ]. It is an innovative excipient that gives new levels of solubility and bioavailability of poorly water-soluble drugs and natural compounds both for oral and parenteral administration [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Solutol ® HS15 (polyoxyethylene esters of 12-hydroxystearic acid, Figure 2 ) is a known non-ionic surfactant with high solubility and stability and low toxicity in vivo.…”
Section: Introductionmentioning
confidence: 99%
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“…The CSNPs were prepared using the ionic gelation method with TPP. Although both nanosystems improved the aqueous solubility of the extract, only the polymeric micelle system, which possessed higher encapsulation efficiency and better release profile, was able to inhibit cancer cell migration [ 175 ].…”
Section: Chitosan As a Matrix For The Encapsulation Of Plant Extramentioning
confidence: 99%
“…Finally, the inhibitory effect of both nanoformulations was tested on SH-SY5Y cell migration by wound healing assay and compared to that of unformulated POE. Soluplus polymeric micelles improved the inhibitory effect of extract on cell migration probably due to the high encapsulation efficiency and the prolonged release of the extract [8].…”
mentioning
confidence: 99%