Comparison of choroidal thickness measurements between spectral domain optical coherence tomography and swept source optical coherence tomography in children

Abstract

Choroidal thickness is associated with many ocular conditions, interchangeability among different generations of optical coherence tomography is therefore important for both research purpose and clinical application. Hence, we compared choroidal thickness measurements between spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomography (SS-OCT) in healthy paediatric eyes. A total of 114 children from the population-based Hong Kong Children Eye Study with mean age of 7.38 ± 0.82 years were included. Choroidal thickness of the right eye was measured by both devices. The central foveal choroidal thickness (CFCT) measured by SD-OCT and SS-OCT was 273.24 ± 54.29 μm and 251.84 ± 47.12 μm respectively. Inter-device correlation coefficient was 0.840 (95% CI 0.616–0.918). However, choroidal thickness obtained by SD-OCT was significantly thicker than that measured by SS-OCT with a mean difference of 21.40 ± 33.13 μm (P < 0.001). Bland–Altman limit of agreement on the relative difference scale for SD-OCT/SS-OCT was 86.33 μm. Validated conversion equation for translating SD-OCT CFCT measurement into SS-OCT was SS-OCT = 35.261 + 0.810 × SD-OCT. In conclusion, intra-class correlation coefficient (ICC) shows an acceptable agreement between SD-OCT and SS-OCT, however, there was a significant inter-device difference of choroidal thickness measurements in normal children eyes. Therefore, the measurements are not interchangeable.

Macular choroidal thickness and correlations in a healthy pediatric South Asian cohort: A spectral domain optical coherence tomography study

“…Tan et al, however, reported differences between automated and manual ChT measurements between SS-OCT and SD-OCT, which could not be eliminated [36]. Lee et al found significant inter-device differences in ChT analysis in children, and that these measurements were not interchangeable [37]. Automated and manual segmentation methods for ChT may be interchangeable however, in healthy eyes, with automated methods being preferred and having more value in large scientific clinical research and routine patient assessment [38].…”

Choroidal thickness, myopia, and myopia control interventions in children: a Meta-analysis and systemic review

“…In the current study, the OCT type was the primary cause of heterogeneity. It is suggested that ChT measured on SS-OCT was 5.9 to 49.3 μm thinner than that on spectral domain OCT, and there was a significant inter-device difference of ChT measurements in normal children [58] . Fontaine et al [35] found that ChT tends to increase from early childhood to adolescence in normal children without refractive errors, peaking in young adulthood, but then decreases with age in older populations.…”

Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography

“…Owing to its greater scanning depth, SS-OCT (Version 9.31, Topcon Co., Tokyo, Japan) provides an advantage in visualizing the choroid [20][21] . According to previous articles [22] , the retinal and choroidal thicknesses have been defined respectively.…”