1990
DOI: 10.1111/j.1600-065x.1990.tb00040.x
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Comparison of Class I MHC Alleles in Humans and Apes

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Cited by 134 publications
(75 citation statements)
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“…We isolated two Mamu-I alleles in addition to other Mamu-B alleles in the offspring of two adult macaques, and the alleles of this locus were segregated and inherited in a Mendelian fashion, suggesting that they represented alleles of a separate locus. Because MHC class I A-H loci already exist in primates (8,(17)(18)(19)35), we have called this new locus Mamu-I in accordance with established nomenclature guidelines (25). We were unable to detect an I locus on the a haplotype (Fig.…”
Section: Alleles At This New Locus Are Inherited In a Mendelian Fashionmentioning
confidence: 73%
“…We isolated two Mamu-I alleles in addition to other Mamu-B alleles in the offspring of two adult macaques, and the alleles of this locus were segregated and inherited in a Mendelian fashion, suggesting that they represented alleles of a separate locus. Because MHC class I A-H loci already exist in primates (8,(17)(18)(19)35), we have called this new locus Mamu-I in accordance with established nomenclature guidelines (25). We were unable to detect an I locus on the a haplotype (Fig.…”
Section: Alleles At This New Locus Are Inherited In a Mendelian Fashionmentioning
confidence: 73%
“…Similarly, an analysis of the nucleotide sequence relationships among 16 HLA-A alleles using maximum parsimony suggest these alleles cluster according to serological typing, again with the exception of A30 which grouped with the A3/11/1 family. 18 However, this study is limited by assessment of a single allele from each serological grouping and a lack of statistical analysis of the phylogenetic clusters. Likewise, an analysis of complete cDNA sequences of 14 HLA-C alleles revealed that HLA-C alleles divide into two groups, one comprising the Cw7 sero-type, and the other group including all remaining alleles.…”
Section: Correspondence: Stephen J O'brien Phd Laboratory Of Genomimentioning
confidence: 99%
“…32 (HCV is hepatotropic and replicates efficiently in chimpanzees-and the genotype 1 strain, HCV-1, typically establishes chronic infection. Exceptionally for an animal model of human disease, chimpanzees share with humans orthologous MHC 51,52 and TCR 53,54 genes.) This study revealed that a multispecific, intrahepatic CD8 ϩ CTL response during early infection correlated with HCV-1 clearance.…”
Section: Cell-mediated Immunitymentioning
confidence: 99%