Comparison of clevidipine with sodium nitroprusside in the control of blood pressure after coronary artery surgery

Powroznyk, A. V. V.; Vuylsteke, Alain; Naughton, Corina; Misso, Saverio; Holloway, Jacob B.; Jolin‐Mellgård, Å.; Latimer, R.D.; Nordlander, Margareta; Feneck, R. O.

doi:10.1097/00003643-200309000-00004

Cited by 58 publications

(22 citation statements)

References 21 publications

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“…Seven studies are related to the pharmacokinetics and pharmacodynamics of the compound, [8][9][10][11][12][13][14] and five are clinical safety and efficacy trials. [15][16][17][18][19] In addition, one trial subset analysis was identified through cross-referencing. 20…”

Section: Resultsmentioning

confidence: 99%

“…26,27 A modest increase in heart rate was observed during clevidipine administration, as has been reported with other IV dihydropyridines 28,29 and in studies of clevidipine in essential hypertension and postcardiac surgery. 14,15 Clevidipine and placebo were both produced no considerable changes in HR after infusion discontinuation and the HR increase initially observed was not substantial. Both treatment groups presented similar rates of AEs, including pyrexia, atrial fibrillation, acute renal failure, and nausea in descending order.…”

Section: Escape-1 Trialmentioning

confidence: 92%

“…A search of PubMed was conducted using the words clevidipine AND clinical trial [Publication Type], which returned 12 results (Table 1). [8][9][10][11][12][13][14][15][16][17][18][19] References provided in these articles found were also searched by citation index to locate other clinical trials that investigated the use of clevidipine in the treatment of hypertension. Cross-referencing of other sources was also performed by the author.…”

Section: Methodsmentioning

confidence: 99%

“…In 2003 in a double blind, randomized trial entitled Comparison of clevidipine with sodium nitroprusside in the control of blood pressure after coronary artery surgery, Powroznyk and colleagues compared sodium nitroprusside (SNP) and clevidipine in the management of postoperative hypertension and monitored hemodynamic changes in patients undergoing coronary artery bypass graft surgery (CABG) 15 as postoperative hypertension occurs in 30%-50% of all patients undergoing the procedure. 25 The study included 30/39 patients who met the inclusion criteria divided in 2 groups.…”

Section: Clinical Safety and Efficacy Trialsmentioning

confidence: 99%

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Clevidipine in Acute Hypertension: The Evidence of its Therapeutic Value

Varon

2010

Clinical Medicine Reviews in Vascular Health

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While the chronic form of hypertension is most common; the acute form presents the greater danger, with more frequent and severe complications and poorer short-term prognosis compared to chronic hypertension. Antihypertensive drugs are used to treat acute hypertension according to the condition of the patient, target organ injured, and the resources available to monitor the patient. However, the limited number of medications intended for the aggressive management of acute hypertensive has highlighted the need for newer drugs that offer a rapid decrease of blood pressure (BP) without increasing the possible complications. After ten years of research and trials, clevidipine was approved by the FDA in 2008, and has been widely used to reduce BP when oral therapy is inappropriate. Compared to the few agents previously used for this purpose clevidipine takes the lead due to its shorter duration of action and its lower incidence of adverse events and toxicity rates.

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Section: Resultsmentioning

confidence: 99%

Section: Escape-1 Trialmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Clinical Safety and Efficacy Trialsmentioning

confidence: 99%

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Clevidipine in Acute Hypertension: The Evidence of its Therapeutic Value

Varon

2010

Clinical Medicine Reviews in Vascular Health

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“…Moreover, clevidipine has been shown to protect against ischemia/reperfusion injury in an animal model of myocardial ischemia and to maintain renal function and splanchnic blood flow. [87][88][89] Several small trials 90,91 have shown clevidipine to be very effective in the control of postoperative hypertension. Although no studies have investigated the role of this drug in hypertensive emergencies, its profile makes it a potentially ideal drug for this indication.…”

Section: Clevidipinementioning

confidence: 99%