Comparison of clinical and hormonal characteristics among four phenotypes of polycystic ovary syndrome based on the Rotterdam criteria

Jamil, Avin S; Alalaf, Shahla K.; Al-Tawil, Namir G.; Al-Shawaf, Talha

doi:10.1007/s00404-015-3889-5

Cited by 59 publications

(50 citation statements)

References 39 publications

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Section: Discussionmentioning

confidence: 99%

“…Positive aspects of this study included the significant number of subjects in the study of a homogeneous Caucasian population, the type A phenotype for PCOS all with the same 3 diagnostic criteria fulfilled where AMH noted to be the highest in this population. 10,16 All patients had polycystic ovaries on ultrasound, and therefore, it might have expected all of the AMH values to be elevated. Why this was not the case is likely due to the observation that AMH values have been shown to be lower in anovulation, and many of these patients may have been anovulatory, although this was not determined in this study.…”

Section: Discussionmentioning

confidence: 99%

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Anti‐Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome

Sathyapalan

Al-Qaissi

Dargham

et al. 2017

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti‐Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome

Sathyapalan

Al-Qaissi

Dargham

et al. 2017

Clinical Endocrinology

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“…There is also some evidence that women with the PCOS phenotypes A and B have an increased risk of hepatic steatosis as compared with women with PCOS with the nonhyperandrogenic phenotype and compared with healthy controls (83,84). The highest antim€ ullerian hormone levels are also found in patients with classic PCOS (85)(86)(87). Data from 1,297 women with PCOS from Greece have shown that menstrual cycle pattern is more irregular in these women as compared with phenotype D but seems to normalize with ageing (88).…”

Section: ''Classic'' Pcos (Phenotypes a And B)mentioning

confidence: 99%

Criteria, prevalence, and phenotypes of polycystic ovary syndrome

Lizneva

Suturina

Walker

et al. 2016

Fertility and Sterility

949

557

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Polycystic ovary syndrome (PCOS) is a highly prevalent disorder effecting reproductive-aged women worldwide. This article addresses the evolution of the criteria used to diagnosis PCOS; reviews recent advances in the phenotypic approach, specifically in the context of the extended Rotterdam criteria; discusses limitations of the current criteria used to diagnosis, particularly when studying adolescents and women in the peri- and postmenopause; and describes significant strides made in understanding the epidemiology of PCOS. This review recognizes that although there is a high prevalence of PCOS, there is increased variability when using Rotterdam 2003 criteria, owing to limitations in population sampling and approaches used to define PCOS phenotypes. Last, we discuss the distribution of PCOS phenotypes, their morbidity, and the role that referral bias plays in the epidemiology of this syndrome.

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“…Interviewers also asked participants: at what age their menstrual periods became regular or if it never became regular; and if their periods became regular naturally, because of birth pills, or in some other way. Other PCOS-related symptoms/sequelae such as acne, obesity (weight and height), OC use, history of infertility, age at menarche and age at first birth were also assessed at the interview, and covariates were defined based on the Rotterdam criteria and previous studies regarding clinical features of PCOS [34, 35]. The interviewers also inquired if the participants had physician-diagnosed diseases that are associated with metabolic syndrome such as hypertension, diabetes mellitus and hypercholesterolemia.…”

Section: Methodsmentioning

confidence: 99%

Polycystic ovarian syndrome (PCOS), related symptoms/sequelae, and breast cancer risk in a population-based case–control study

Kim

Mersereau

Khankari

et al. 2016

Cancer Causes Control

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Purpose Despite the overlap between the clinical symptoms/sequelae of polycystic ovarian syndrome (PCOS) and many known reproductive risk factors for breast cancer, the relationship between PCOS and breast cancer remains unclear, possibly because of the complex heterogeneity and challenges in diagnosing PCOS over time. We hypothesized that PCOS, specific PCOS-related symptoms/sequelae, or clusters of PCOS-related symptoms/sequelae, may be differentially associated with pre- vs. postmenopausal breast cancer risk. Materials and Methods Cases were 1,508 women newly diagnosed with a first primary in situ or invasive breast, and the 1,556 population-based controls were frequency-matched by age. Results History of physician-diagnosed PCOS was reported by 2.2% (n=67), among whom oral contraceptive (OC) use, irregular menstruation, and infertility due to ovulatory dysfunction were common. Using unconditional logistic regression, adjusted odds ratios (95% confidence intervals) for PCOS were increased for premenopausal [2.74 (1.13, 6.63)], but not post-menopausal breast cancer [0.87 (0.44, 1.71)]. We used cluster analysis to investigate whether risk among all women varied by PCOS-related symptoms/sequelae, such as reproductive irregularities, OC use, and components of insulin resistance. In the cluster analysis, odds ratios were elevated among premenopausal women who had a history of OC use and no ovulatory dysfunction [1.39 (1.03, 1.88)], compared to those with fewer number of PCOS-related symptoms/sequelae. Conclusion PCOS, and associated PCOS-related symptoms/sequelae including OC use, may play a role in the development of premenopausal breast cancer. Our findings require confirmation in studies with a larger number of premenopausal women with systematically applied diagnostic criteria for PCOS.

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Comparison of clinical and hormonal characteristics among four phenotypes of polycystic ovary syndrome based on the Rotterdam criteria

Cited by 59 publications

References 39 publications

Anti‐Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome

Anti‐Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome

Criteria, prevalence, and phenotypes of polycystic ovary syndrome

Polycystic ovarian syndrome (PCOS), related symptoms/sequelae, and breast cancer risk in a population-based case–control study

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