Comparison of clinical and serological parameters in female and male patients with systemic sclerosis

Wielosz, Ewa; Majdan, Maria; Dryglewska, Magdalena; Suszek, Dorota

doi:10.5114/reum.2015.57637

Cited by 10 publications

(8 citation statements)

References 27 publications

(40 reference statements)

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“…Systemic sclerosis is more common in women than men; however, the course of the disease may be more progressive in men [29]. Similar to other populations, i.e.…”

Section: Discussion_____________________________mentioning

confidence: 58%

Evaluation of Autoantibodies in patients with Systemic Sclerosis

et al. 2020

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Systemic sclerosis (SSc, scleroderma) is a multisystemic chronic autoimmune connective tissue disorder characterized by extensive fibrosis, vascular abnormalities, and immune dysfunction [1]. The exact etiopathogenesis of SSc remains unknown, although in genetically susceptible individuals, environamental triggers and dysregulated epigenetic changes contribute to the development of SSc [2]. Systemic sclerosis is more prevalent in black people; however, it is found in all racial groups and all geographic regions [3]. A serological hallmark of systemic sclerosis is the presence of serum autoantibodies against various intracellular antigens. Autoantibodies have been observed at first diagnosis in more than 95% of patients affected with systemic sclerosis [4]. Each of the autoantibodies is beneficial in the diagnosis of affected patients. Different autoantibodies have been associated with different disease subtypes and with differences in disease severity, including the extent of skin involvement, internal organ manifestations, as well as determining the prognosis [5]. All of these antibodies are directed against structures within the nucleus of the cell and, thus, are ANAs. Some ANAs, including ACA, ATA/anti-Scl-70 antibody, antifibrillarin/anti-U3-ribonucleoprotein (AFA), anti-PM/Scl antibody, anti-Th/To antibody, and anti-RNAP III are found in the sera of systemic sclerosis patients [4]. Original Article Open Access Systemic sclerosis is an autoimmune disease clinically characterized by vascular and immune dysfunction, leading to fibrosis that can damage multiple organs. The presence of non-overlapping SSc-associated autoantibodies best presents the autoimmune nature of systemic sclerosis. The primary purpose of this study was to investigate the autoantibody profile in Iranian patients with systemic sclerosis. Sera from 481 patients with systemic sclerosis were collected from 2013 to 2016. Levels of anti-nuclear antibodies (ANA) were quantitatively detected using the indirect immunofluorescence (IIF) method, and levels of specific autoantibodies including anti-topoisomerase I antibody (ATA), anti-centromere antibody (ACA) and anti RNA polymerase III antibody (anti-RNAP III) were determined qualitatively using the enzyme-linked immunosorbent assay (ELISA) technique. Among all patients evaluated, a predominance of females (86.7%) was found, and 434 (90.2%) patients showed positive ANA results by IIF. ANA was detected in 87.3% and 92.0% of limited cutaneous systemic sclerosis (lcSSc) and diffuse cutaneous systemic sclerosis (dcSSc) patients, respectively, which was not significantly different. The frequency of anti-RNAP III, ACA, and ATA was 5.19%, 6.09%, and 72.3%, respectively. Furthermore, anti-RNAP III, ATA, and ANA levels were correlated with dcSSc, whereas ACA levels were correlated with lcSSc. It was confirmed that ATA expression is significantly higher in dcSSc patients. This study had a lower frequency of ACA (6.09%) than most previous cohorts. The results demonstrated that the clinical subtype of systemic s...

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“…Systemic sclerosis is more common in women than men; however, the course of the disease may be more progressive in men [29]. Similar to other populations, i.e.…”

Section: Discussion_____________________________mentioning

confidence: 58%

Evaluation of Autoantibodies in patients with Systemic Sclerosis

et al. 2020

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“…Also, the female to male ratio was 1.6 : 1 in Sittichai Netwijitpan’s study on hospitalized patients [ 4 ]. In a study done by Wielosz et al [ 11 ] on European Caucasian patients, this ratio was 3.1 : 1. Although in a study done in Italy (Sardinia) on 4981 hospitalizations in 2001–2012, the women’s admissions was 84.8% that was nearly the same as our patients [ 12 ].…”

Section: Discussionmentioning

confidence: 90%

“…In our study, the majority of the patients had dcSSc (91.03%). Netwijitpan et al [ 4 ] also reported that 81.7% of the hospitalized SSc patients had dcSSc although in a European study the admissions were more in patients with LcSSc [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of hospitalization and mortality of scleroderma in-patients: a thirteen-year study

Shenavandeh¹,

Naseri²

2017

Reumatologia

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ObjectiveSystemic sclerosis (SSc) is an uncommon non-hereditary sporadic disease that increases the risk of premature death, especially in diffuse type. We determined the prevalence of SSc in the last 13 years in our rheumatologic hospitals as a referral center for southern Iranian patients, the causes of hospitalization, the average length of stay (LOS), the mortality rate, and the reason for their mortality.Material and methodsA cross-sectional study was performed in Shiraz University of Medical Sciences, Iran. The studied population included all patients diagnosed with systemic sclerosis. We calculated the hospitalization rates, in-hospital mortality rates, and mean LOS.ResultsThere were 446 admissions by 181 patients with SSc. The female to male ratio was about 10.7 : 1. The overall mean LOS was 5.95 days. Digital ulcer and interstitial lung disease (ILD) were the most common causes of hospitalizations among the SSc-related events. For those with a non-SSc-related condition, infection was the most prevalent event. Most of the deaths were due to ILD and pulmonary artery hypertension(PAH), and the overall in-hospital mortality rate was 16.5%.ConclusionsWomen with SSc had higher rates of hospitalization but lower in-hospital mortality than men.There were some differences between our study and other similar studies in the causes of hospitalization and in-hospital death among SSc patients, especially the lower age of death. The patients with digital ulcers and those with intestinal lung disease or pulmonary hipertension were most commonly admitted to the hospital in our study group. Probably, increasing the skin care of these patients and asking other specialty groups to cooperate will decrease the high rate of hospitalizations in our population.

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“…24 In our study, male patients had a higher prevalence of diffuse cutaneous systemic sclerosis, which was in agreement with several other studies. 25,26 The prevalence of anti-topoisomerase-I positivity was high in the present series compared to those in Caucasians, 10,27 Africans, 28 and other Asian 29,30 countries. It was however similar to the rates in the Chinese 31 and Indian 32 populations.…”

Section: Resultsmentioning

confidence: 43%

Associations of autoantibodies and clinical profile of the patients with systemic sclerosis

Mahmud

Choudhury

Bandhan

et al. 2022

Rheumatology & Autoimmunity

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Background: Systemic sclerosis is characterized by the involvement of organs and the presence of specific antibodies. The objectives of this study were to identify the autoantibodies and to determine their association with the selected clinical features of the disease among Bangladeshi systemic sclerosis patients. Methods: This cross-sectional study was performed at the rheumatology outpatient clinic of Bangabandhu Sheikh Mujib Medical University. Autoantibodies against nine systemic sclerosis-specific antigens were tested using an enzyme-linked immunoassay immunoblot kit. Several clinical features of patients with positive and negative autoantibody were examined by χ 2 or Fisher's exact tests. Results: A total of 71 patients with systemic sclerosis (66; 93.0% female) were included. Their mean age at disease onset was 33.2 years. Fifty-seven (80.3%) patients had diffuse cutaneous subtype. Out of nine autoantibodies, four were positive, anti-topoisomerase-I (57.7%), anti-U1 ribonucleic protein (21.1%), anti-RNA polymerase III (18.3%), and anticentromere antibodies (4.2%). Eleven (15.5%) patients were negative for any antibodies and 11 patients were positive for at least two autoantibodies. Anti-U3-RNP, anti-PM-Scl, anti-Ku, and anti-Th/To auto antibodies were absent in all patients. Anti-RNA polymerase III was associated with raised pulmonary arterial systolic pressure (PASP) and anti-U1-RNP with decreased forced vital capacity (FVC). Conclusions: Anti-topoisomerase-I was the commonest autoantibody in patients with systemic sclerosis in Bangladesh. Anti-RNA polymerase III antibody had significant association with raised PASP and anti-U1-RNP with decreased FVC.

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Comparison of clinical and serological parameters in female and male patients with systemic sclerosis

Cited by 10 publications

References 27 publications

Evaluation of Autoantibodies in patients with Systemic Sclerosis

Evaluation of Autoantibodies in patients with Systemic Sclerosis

Assessment of hospitalization and mortality of scleroderma in-patients: a thirteen-year study

Associations of autoantibodies and clinical profile of the patients with systemic sclerosis

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