Comparison of Clinical Characteristics Between Benign Borderline and Malignant Phyllodes Tumors of the Breast

Wang, Hui; Wang, Xiang; Wang, Chengfeng

doi:10.7314/apjcp.2014.15.24.10791

Cited by 26 publications

(22 citation statements)

References 14 publications

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“…Our median tumor size was 35 mm, and a larger tumor size was associated with a higher malignant likelihood. This mirrors findings at the Memorial Sloan Kettering 5 and a recent Asian study 6 . Preoperative ultrasound was able to reliably predict final pathology size with 90% accuracy in our series.…”

Section: Variable Adjusted Odds Ratioa (95% Ci) P Valuesupporting

confidence: 88%

Preoperative radiological and histological features predict phyllodes tumor grade

et al. 2020

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Section: Variable Adjusted Odds Ratioa (95% Ci) P Valuesupporting

confidence: 88%

Preoperative radiological and histological features predict phyllodes tumor grade

et al. 2020

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“…Patients should review at least once every 6 months during the first 2 years and then once a year thereafter. Since the prognosis was closely related to the histopathological subgroup, the extent of primary surgical resection, and medical history of previous fibroadenomam, 35 patients with these risk factors should have more frequent review.…”

Section: Discussionmentioning

confidence: 99%

Huge borderline phyllodes breast tumor with repeated recurrences and progression toward more malignant phenotype: a case report and literature review

Zhang

Chen

Liu

et al. 2018

OTT

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BackgroundPhyllodes tumor (PT) is a rare breast fibroepithelial biphasic tumor composed of stromal and epithelial components. The patients suffering from this disease present with a large, round, mobile, fast-growing lump, and the giant PT of more than 10 cm in diameter is so uncommon. Surgery is regarded as the primary treatment, but curative efficiency of adjuvant chemotherapy and radiotherapy is so indefinite.Case presentationWe reported one case of a middle-aged woman with a huge borderline PT in the right breast, over 20 cm in size. The pathology of needle core biopsy of the lump was suggestive of PT of the borderline subgroup, and then she underwent mastectomy of the right breast. The patient had recovered well without any postoperative treatment until a local recurrence occurred 1 year after operation. The tumor was removed with lumpectomy, which was pathologically diagnosed as malignant PT. We followed up her by telephone and heard about her postoperative adjuvant radiotherapy and chemotherapy, as well as her well recovery.ConclusionThe pathology of PT with low incidence is mostly benign, but local recurrence is common, and the histopathology progresses toward worsen trend. Besides, due to the difficulty in precise diagnosis of the borderline PTs, it is recommended that this subtype of patients should undergo total mastectomy. Although the curative effect of postoperative treatment has not been recognized internationally, patients, especially those with huge tumors, may benefit from these treatments.

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“…How often do phyllodes tumours metastasize, and do benign tumours ever do so? Table shows metastatic rates according to phyllodes tumour grades that have been described by various authors . The singular documentations of metastatic disease following a diagnosis of benign phyllodes tumour were by Abdalla et al .…”

Section: Biological Behaviour and Metastatic Potential Of Phyllodes Tmentioning

confidence: 94%

Phyllodes tumours of the breast: a consensus review

Ács²,

et al. 2015

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Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours.

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Comparison of Clinical Characteristics Between Benign Borderline and Malignant Phyllodes Tumors of the Breast

Cited by 26 publications

References 14 publications

Preoperative radiological and histological features predict phyllodes tumor grade

Preoperative radiological and histological features predict phyllodes tumor grade

Huge borderline phyllodes breast tumor with repeated recurrences and progression toward more malignant phenotype: a case report and literature review

Phyllodes tumours of the breast: a consensus review

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