Comparison of clinical-computed tomography model with 2D and 3D radiomics models to predict occult peritoneal metastases in advanced gastric cancer

Huang, Jian; Chen, Yidi; Zhang, Yuying; Xie, Jinhuan; Liang, Yi-Qiong; Yuan, Wenzhao; Zhou, Ting; Gao, Ruizhi; Wen, Rong; Xia, Yuwei

doi:10.1007/s00261-021-03287-2

Cited by 19 publications

(7 citation statements)

References 43 publications

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“…As an easily accessible clinical examination, CA125 also played a key role in the diagnosis of gastrointestinal malignant tumors [ 18 , 19 ]. Studies have shown that CA125 level was a predictive factor of peritoneal metastases in gastric cancer [ 20 , 21 ] and normalization of CA125 was relevant with better survival [ 22 ]. Thus, we assumed that CA125 level has an impact on the prognosis of GIST patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors

et al. 2023

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Background Carbohydrate antigen 125 (CA125) is elevated as a tumor marker in many carcinomas, but its association with gastrointestinal stromal tumor (GIST) has received less attention. This study intends to evaluate whether CA125 level can predict tumor progression and overall survival (OS) of GIST patients. Methods We retrospectively analyzed the clinical data and follow-up records of GIST patients who underwent surgical resection in Nanjing Drum Tower Hospital from August 2010 to December 2020. All patients were classified according to serum CA125 level. The relationship between CA125 and clinical outcomes was then examined. Results A total of 406 GIST patients were enrolled in this study, among which 46 patients had preoperative elevated serum CA125 level and 13 patients with high CA125 level both preoperative and postoperative were observed. Preoperative CA125 concentration was significantly related to rupture status, resection style, tumor site, tumor size, mitotic index, NIH risk grade and c-kit exons. According to Kaplan–Meier curve analysis, high expression of postoperative CA125 was significantly correlated with worse progression-free survival (PFS) and OS among patients with preoperative elevated CA125 level. Ultimately, Cox proportional regression model analysis revealed that increase of preoperative and concurrent postoperative CA125 concentration was an independent predictive factor for PFS. Conclusions The concurrent abnormality of serum CA125 before and after operation was an independent risk factor for GIST progression, suggesting its significance as a serum biomarker in the overall management of GIST patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors

et al. 2023

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“…It was difficult to accurately delineate. Second, the three-dimensional method can more accurately and fully characterize the voxel characteristics than the two-dimensional method, as shown in previous studies [26,27]. In recent years, there have been several studies similarly exploring the role of MRI based radiomics for LVI in patients with rectal cancer [28,29].But differently, we focused on those patients with negative statue of mrEMVI.…”

Section: Discussionmentioning

confidence: 91%

Biparametric magnetic resonance imaging-based radiomics features for prediction of lymphovascular invasion in rectal cancer

et al. 2023

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Background Preoperative assessment of lymphovascular invasion(LVI) of rectal cancer has very important clinical significance. However, accurate preoperative imaging evaluation of LVI is highly challenging because the resolution of MRI is still limited. Relatively few studies have focused on prediction of LVI of rectal cancer with the tool of radiomics, especially in patients with negative statue of MRI-based extramural vascular invasion (mrEMVI).The purpose of this study was to explore the preoperative predictive value of biparametric MRI-based radiomics features for LVI of rectal cancer in patients with the negative statue of mrEMVI. Methods The data of 146 cases of rectal adenocarcinoma confirmed by postoperative pathology were retrospectively collected. In the cases, 38 had positive status of LVI. All patients were examined by MRI before the operation. The biparametric MRI protocols included T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI). We used whole-volume three-dimensional method and two feature selection methods, minimum redundancy maximum relevance (mRMR) and least absolute shrinkage and selection operator (LASSO), to extract and select the features. Logistics regression was used to construct models. The area under the receiver operating characteristic curve (AUC) and DeLong’s test were used to evaluate the diagnostic performance of the radiomics based on T2WI and DWI and the combined models. Results Radiomics models based on T2WI and DWI had good predictive performance for LVI of rectal cancer in both the training cohort and the validation cohort. The AUCs of the T2WI model were 0.87 and 0.87, and the AUCs of the DWI model were 0.94 and 0.92. The combined model was better than the T2WI model, with AUCs of 0.97 and 0.95. The predictive performance of the DWI model was comparable to that of the combined model. Conclusions The radiomics model based on biparametric MRI, especially DWI, had good predictive value for LVI of rectal cancer. This model has the potential to facilitate the clinical recognition of LVI in rectal cancer preoperatively.

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“…A dramatic development is occurring in the field of radiomics for gastric cancers. For example, radiomics has been used to predict T stage [ 13 ], N stage [ 14 , 15 ], M stage [ 16 , 17 ], neoadjuvant chemotherapy [ 18 , 19 ], Lauren classification [ 20 ], and histological grade [ 21 ]. Studies showed that CT radiomics is an important preoperative predictor and provides prognostic information for pathological staging markers [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Can PD-L1 expression be predicted by contrast-enhanced CT in patients with gastric adenocarcinoma? a preliminary retrospective study

Shi

et al. 2022

Abdom Radiol

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Background This study aimed to construct a computed tomography (CT) radiomics model to predict programmed cell death-ligand 1 (PD-L1) expression in gastric adenocarcinoma patients using radiomics features. Methods A total of 169 patients with gastric adenocarcinoma were studied retrospectively and randomly divided into training and testing datasets. The clinical data of the patients were recorded. Radiomics features were extracted to construct a radiomics model. The random forest-based Boruta algorithm was used to screen the features of the training dataset. A receiver operating characteristic (ROC) curve was used to evaluate the predictive performance of the model. Results Four radiomics features were selected to construct a radiomics model. The radiomics signature showed good efficacy in predicting PD-L1 expression, with an area under the receiver operating characteristic curve (AUC) of 0.786 (p < 0.001), a sensitivity of 0.681, and a specificity of 0.826. The radiomics model achieved the greatest areas under the curve (AUCs) in the training dataset (AUC = 0.786) and testing dataset (AUC = 0.774). The calibration curves of the radiomics model showed great calibration performances outcomes in the training dataset and testing dataset. The net clinical benefit for the radiomics model was high. Conclusion CT radiomics has important value in predicting the expression of PD-L1 in patients with gastric adenocarcinoma.

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Comparison of clinical-computed tomography model with 2D and 3D radiomics models to predict occult peritoneal metastases in advanced gastric cancer

Cited by 19 publications

References 43 publications

Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors

Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors

Biparametric magnetic resonance imaging-based radiomics features for prediction of lymphovascular invasion in rectal cancer

Can PD-L1 expression be predicted by contrast-enhanced CT in patients with gastric adenocarcinoma? a preliminary retrospective study

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