Comparison of clinical efficacy of three different dentin matrix biomaterials obtained from different devices

Dłucik, Robert; Orzechowska-Wylęgała, Bogusława; Dłucik, Daniel; Puzzolo, Domenico; Santoro, Giuseppe; Micali, Antonio; Testagrossa, Barbara; Acri, Giuseppe

doi:10.1080/17434440.2023.2190512

Cited by 7 publications

(5 citation statements)

References 47 publications

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“…Different devices are available on the market for grinding extracted teeth. A study conducted in 2023 by Dłucik R et al [ 48 ] compared the efficacy of three DDMs obtained from different medical devices on the market (Tooth Transformer Smart, Smart Dentin Grinder and BonMaker). Despite some variations in structures and chemical compositions of the granules, the authors concluded that all of the devices could generate particles with adequate characteristics for bone regeneration.…”

Section: Resultsmentioning

confidence: 99%

Osteoinductive Properties of Autologous Dentin: An Ex Vivo Study on Extracted Teeth

Mazzucchi,

Mariano,

Serafini

et al. 2024

JFB

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Over the last decades, a variety of biomaterials, ranging from synthetic products to autologous and heterologous grafts, have been recommended to conserve and regenerate bone tissue after tooth extraction. We conducted a biochemical study on ground extracted teeth that aimed to evaluate the osteoinductive and osteoconductive potential of dentin by assessing the releases of bone morphogenetic protein (BMP-2), osteocalcin (OC) and osteonectin (ON) over time (24 h, 10 days and 28 days). Twenty-six patients, who required the extraction of nonrestorable teeth, were enrolled in the study according to the inclusion criteria, as follows: thirteen young patients 18 to 49 years of age (UNDER 50), and thirteen patients of 50 to 70 years (OVER 50); a total of twenty-six teeth were extracted, ground and analyzed by enzyme-linked immunosorbent assays (ELISA). All ground teeth released BMP-2, OC and ON at each time point; no differences were observed between the UNDER-50 and OVER-50 patients. The results of the study support the use of autologous dentin as osteoinductive material for bone regeneration procedures, irrespective of patients’ ages.

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Section: Resultsmentioning

confidence: 99%

Osteoinductive Properties of Autologous Dentin: An Ex Vivo Study on Extracted Teeth

Mazzucchi,

Mariano,

Serafini

et al. 2024

JFB

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“…Unfortunately, current scientific evidence highlights that this is not yet realistic, and the majority of biomaterials work in exactly the same way, that is, they provide an optimal scaffold to give blood clots the possibility of proceeding with optimal healing via primary intervention. Therefore, studies that take into consideration the dentin and pulp of extracted teeth subjected to decalcification to fill postextraction sites are not interesting; the shredded dentin continues to progress as part of the bone and presents a cost-free autologous material [42][43][44][45]. Further, in this regard, researchers [46][47][48][49][50][51][52] have paid great attention to platelet concentrates and the different ways of preparing them.…”

Section: Discussionmentioning

confidence: 99%

The Use of Nano-Hydroxyapatite (NH) for Socket Preservation: Communication of an Upcoming Multicenter Study with the Presentation of a Pilot Case Report

Rossi,

Carli,

Bambini

et al. 2023

Medicina

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Background and Objectives: The use of biomaterials in dentistry is extremely common. From a commercial perspective, different types of osteoconductive and osteoinductive biomaterials are available to clinicians. In the field of osteoconductive materials, clinicians have biomaterials made of heterologous bones at their disposal, including biomaterials of bovine, porcine, and equine origins, and biomaterials of natural origin, such as corals and hydroxyapatites. In recent years, it has become possible to synthesize nano-Ha and produce scaffolds using digital information. Although a large variety of biomaterials has been produced, there is no scientific evidence that proves their absolute indispensability in terms of the preservation of postextraction sites or in the execution of guided bone regeneration. While there is no scientific evidence showing that one material is better than another, there is evidence suggesting that several products have better in situ permanence. This article describes a preliminary study to evaluate the histological results, ISQ values, and prevalence of nano-HA. Materials and Methods: In this study, we planned to use a new biomaterial based on nanohydroxyapatite for implantation at one postextraction site; the nano-HA in this study was NuvaBONE (Overmed, Buccinasco, Milano, Italy). This is a synthetic bone graft substitute that is based on nanostructured biomimetic hydroxyapatite for application in oral–maxillofacial surgery, orthopedics, traumatology, spine surgery, and neurosurgery. In our pilot case, a patient with a hopeless tooth underwent extraction, and the large defect remaining after the removal of the tooth was filled with nano-HA to restore the volume. Twelve months later, the patient was booked for implant surgery to replace the missing tooth. At the time of the surgery, a biopsy of the regenerated tissue was taken using a trephine of 4 mm in the inner side and 8 mm deep. Results: The histological results of the biopsy showed abundant bone formation, high values of ISQ increasing from the insertion to the prosthetic phase, and a good reorganization of hydroxyapatite granules during resorption. The implant is in good function, and the replaced tooth shows good esthetics. Conclusions: The good results of this pilot case indicate starting the next Multicentric study to have more and clearer information about this nanohydroxyapatite (NH) compared with control sites.

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“…Recently, a study has been published on the different devices on the market that can make a tooth a suitable material for grafting in a bone defect. Such devices are the BonMaker, the TT and the Smart Dentin Grinder [44].…”

Section: Discussionmentioning

confidence: 99%

Biological Evaluation of the Osteoinductive Potential of Dry Teeth after Chemical Demineralization Treatment Using the Tooth Transformer Device

Franceschelli,

Lagioia,

De Cecco

et al. 2023

Biomolecules

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Several studies have already demonstrated the biocompatibility of a tooth as a grafting material in the regeneration of bone tissue, showing its osteoconductive potential, while no studies have verified whether the osteoinductive potential of a tooth remains constant or is altered after its treatment with the Tooth Transformer (TT) device. The aim of the study was to demonstrate that the treatment with the TT device did not alter the osteoinductivity of an extracted tooth that was stored dry. Twelve extracted human teeth were collected from real patients. Caries, tartar and filling materials were removed from each tooth; each tooth was coarsely cut and stored at room temperature (RT) until use. Each sample was shredded, demineralized and disinfected, using the TT device. Protein extraction was carried out for each sample, and Western Blot analysis was performed to test the presence of mineralization protein LIM-1 and transforming growth factor-β. The presence of the human Bone Morphogenetic Protein 2 (BMP-2) and human collagen Type I (COL-I) was found in dry tooth samples processed with the TT device and subjected to Enzyme-Linked Immunosorbent Assay (ELISA) testing. The treatment of chemical demineralization using the TT device does not alter the osteoinductive potential of a dry tooth.

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Comparison of clinical efficacy of three different dentin matrix biomaterials obtained from different devices

Cited by 7 publications

References 47 publications

Osteoinductive Properties of Autologous Dentin: An Ex Vivo Study on Extracted Teeth

Osteoinductive Properties of Autologous Dentin: An Ex Vivo Study on Extracted Teeth

The Use of Nano-Hydroxyapatite (NH) for Socket Preservation: Communication of an Upcoming Multicenter Study with the Presentation of a Pilot Case Report

Biological Evaluation of the Osteoinductive Potential of Dry Teeth after Chemical Demineralization Treatment Using the Tooth Transformer Device

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