Comparison of Clinical Outcomes of Coronavac Vaccinated and Unvaccinated Older Adults With Hospitalized Covid-19

Özdemir, Yusuf

doi:10.31086/tjgeri.2022.321

Cited by 1 publication

(1 citation statement)

References 17 publications

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“… 31 Ozdemir et al demonstrated that the CoronaVac vaccine improved survival rates in hospitalized patients with COVID-19 aged ≥ 65 years. 32 Another clinical study aiming to assess the effectiveness of a two-dose regimen of CoronaVac in adults aged ≥ 70 years determined that CoronaVac administration decreased the incidence of symptomatic diseases, hospital admissions, and deaths. 33 In the present study, there was no significant difference in the 28-day mortality between fully vaccinated (CoronaVac) patients aged < 65 years and those aged 65-74 years.…”

Section: Discussionmentioning

confidence: 99%

The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye

Gül,

Kasapoğlu,

Sabaz

et al. 2023

Balkan Med J

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Background: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear. Aims: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19. Study Design: Multicenter prospective observational clinical study. Methods: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated. Results: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores ( p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) ( p = 0.004). Conclusion: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.

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Section: Discussionmentioning

confidence: 99%