Comparison of Clinical Profiles and Mortality Outcomes Between Influenza and COVID-19 Patients Invasively Ventilated in the ICU: A Retrospective Study From All Paris Public Hospitals From 2016 to 2021

Abstract

OBJECTIVES:Studies comparing outcomes of ICU patients admitted for either COVID-19 or seasonal influenza are limited. Our objective was to describe baseline clinical profiles, care procedures, and mortality outcomes by infection status (influenza vs COVID-19) of patients who received invasive mechanical ventilation in the ICU.

Differences in clinical characteristics and outcomes between COVID-19 and influenza in critically ill adult patients: A national database study

“…Although the difference between groups was not clinically relevant, ICU length of stay was statistically longer in patients with COVID-19 than in those with influenza (7 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 days vs. 7 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 days) (p < 0·001) ( Table 2 ). However, in the subgroups of patients receiving invasive ventilation, ICU length of stay was 18 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 days for patients with COVID-19 vs. 15 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , …”

“…However, in the subgroups of patients receiving invasive ventilation, ICU length of stay was 18 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 days for patients with COVID-19 vs. 15 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 days for patients with influenza (p < 0·001). In the whole population, total hospital LOS was 25 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , ...…”

“… 10 , 11 However, some discrepancies, such as baseline characteristics and outcomes, have been recorded in monocenter studies of patients displaying heterogeneous severity of wild-type SaRS CoV-2. 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 …”

Comparison of Clinical Characteristics and Outcomes in Intensive Care Units Between Patients with Coronavirus Disease 2019 (COVID-19) and Patients with Influenza: A Systematic Review and Meta-Analysis

“…Most of the data were from retrospective studies, 5,10,[15][16][17][18][19][20][22][23][24][25][26][28][29][30][32][33][34][35][37][38][39][40][41][42][43][44][45][46][47] 2 articles were prospective studies, 31,34 and 3 articles did not specify the type of study. 21,27,36 Four articles specifically studied patients with influenza A, 10,21,31,36 15 articles studied patients with type A/B, 5,15,16,20,[24][25][26][27]30,32,33,…”

“…Most of the data were from retrospective studies, 5,10,15–20,22–26,28–30,32–35,37–47 2 articles were prospective studies, 31,34 and 3 articles did not specify the type of study. 21,27,36 Four articles specifically studied patients with influenza A, 10,21,31,36 15 articles studied patients with type A/B, 5,15,16,20,24–27,30,32,33,37,39,40,47 16 articles did not state the influenza type of patients, 17–19,22,23,28,29,34,35,38,…”