Comparison of Clinical, Radiologic, and Serum Marker as Prognostic Factors after Severe Head Injury

Woertgen, Chris; Rothoerl, Ralf Dirk; Metz, Christoph; Brawanski, Alexander

doi:10.1097/00005373-199912000-00026

Cited by 129 publications

(62 citation statements)

References 16 publications

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“…In general, the S100 protein is still regarded as a screening parameter for primary diagnosis owing to its low specificity, despite high sensitivity values. Initial GCS score and Marshall computed tomography classification exhibited similar positive predictive values in terms of short-term prognosis, especially after severe TBI, to increased S100 values (29,34). However, because of high negative predictive levels, acute intracerebral lesions may be ruled out with the highest probability if the systemic concentration of S100 decreases below the cutoff level (18).…”

Section: Bereitgestellt Von | Universitaetsbibliothek Der Lmu Muenchenmentioning

confidence: 79%

“…Discussion S100 protein is reported to be a sensitive and reliable marker of cellular brain damage. It can be applied for both primary diagnosis and long-term prognosis after severe TBI (27)(28)(29)(30)(31)(32). In the past, clinical studies predominantly used the Sangtec ᮋ 100 luminescence immunoassay, which is provided either for the LIAmat ᮋ S100 or the LIAISON ᮋ S100 analyzer (all from DiaSorin S.p.A., Dietzenbach, Germany).…”

Section: Roc Curve Analysis and Auc Calculation For S100 Serum Levelsmentioning

confidence: 99%

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Significance of Elecsys® S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients

Mussack¹,

Kirchhoff²,

Buhmann³

et al. 2006

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: The neuroprotein S100 released into the circulation has been suggested as a reliable marker for primary brain damage. However, safe identification of relevant traumatic brain injury (TBI) may possibly be hampered by S100 release from peripheral tissue. The objective of this study was to measure early S100 levels using the Elecsys ᮋ S100 immunoassay for real-time assessment of severe TBI in multiple trauma. Methods: Consecutively admitted multiple trauma patients (injury severity score G16 points) were stratified according to the results of the initial cerebral computed tomography (CCT) examination. S100 serum levels were determined at admission and at 6, 12, 24, 48 and 72 h after trauma. Data were correlated to creatine phosphokinase (CK) and lactate dehydrogenase (LDH) serum levels. Using receiver operating characteristic (ROC) analysis, the discriminating power of S100 measurement was calculated for the detection of CCTq findings. Results: Median S100 levels of CCTq patients (ns9;

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Section: Bereitgestellt Von | Universitaetsbibliothek Der Lmu Muenchenmentioning

confidence: 79%

Section: Roc Curve Analysis and Auc Calculation For S100 Serum Levelsmentioning

confidence: 99%

Significance of Elecsys® S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients

Mussack¹,

Kirchhoff²,

Buhmann³

et al. 2006

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…(15,23,24) Serum levels of S100B, assessed in the first hours after severe TBI have been better predictors of long term prognosis, when assessed by the GOS scale than the GCS and the CT Marshall scale. (25) Because S100B has a halflife of about 2 hours, increased values due to primary brain damage should return to baseline levels in 12 to 24 hours. (15) S100B is a sensitive marker for early prediction of ICH development.…”

Section: S100bmentioning

confidence: 99%

Biomarcadores prognósticos no traumatismo crânio-encefálico grave

Oliveira¹,

Ikuta²,

Regner³

2008

Rev. bras. ter. intensiva

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“…Positive correlation of S-100β levels with computerized tomography (CT) and magnetic resonance imaging (MRI) findings were documented. [5][6][7][8][9][10] In patients who had suffered mild head trauma, S-100β levels in serum were found to be a specific but not very sensitive predictor for postconcussion symptoms 11 , while no correlation was found between S-100β serum levels and cognitive performance in the early stage of recovery. 12 S-100β serum levels were found to be a This project was designed to measure S-100β levels in serum and urine with the aim to test whether the easier to obtain urine samples could be substituted for serum samples.…”

mentioning

confidence: 94%

Can Admission S-100β Predict the Extent of Brain Damage in Head Trauma Patients?

Schültke

Sadanand²,

Kelly³

et al. 2009

Can. j. neurol. sci.

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612S-100β, a small monomer of the calcium-binding S-100 protein family, is present in high concentrations in astrocytes and Schwann cells. S-100β levels in serum were initially identified as a valuable marker in the assessment of cerebral injury during cardiovascular surgery and stroke. [1][2][3][4] Over the last decade, several groups have published their results correlating S-100β levels in serum to the severity of brain damage and patient outcome. Positive correlation of S-100β levels with computerized tomography (CT) and magnetic resonance imaging (MRI) findings were documented. [5][6][7][8][9][10] In patients who had suffered mild head trauma, S-100β levels in serum were found to be a specific but not very sensitive predictor for postconcussion symptoms 11 , while no correlation was found between S-100β serum levels and cognitive performance in the early stage of recovery. 12 S-100β serum levels were found to be a ABSTRACT: Background: As has been shown previously, S-100β levels in serum can be a useful predictor of brain damage after head trauma. This pilot study was designed to investigate whether urine samples, which are much easier to obtain, could be used for the same purpose instead of serum samples. Methods: Ninety-six consecutive patients admitted with head trauma were recruited in the study. After exclusion of 54 patients, mostly because of significant additional trauma, S-100β levels were analyzed in serum and urine of 42 patients using a luminometric assay. A range for normal values was established based on samples from ten healthy volunteers. Results: S-100β serum levels increased proportional to the severity of the head trauma, as had been previously shown by several other groups. In many patients, initial increases in urine S-100β levels were seen later than in serum, after which the kinetics of S-100β levels in urine seemed to follow that established for serum levels. S-100β values in urine were on average about 54% lower in urine than in serum. Conclusions: S-100β levels in urine obtained on admission to the hospital are not a good indicator for the extent of brain damage. However, urine S-100β levels obtained at later time points might be a useful indicator for the development of secondary brain injury. RÉSUMÉ: Le niveau de S-100β au moment de l'admission peut-il prédire l'étendue du dommage cérébral chez les traumatisés crâniens?Contexte : Tel que démontré antérieurement, les niveaux sériques de S-100β peuvent être utiles pour prédire le dommage cérébral après un traumatisme crânien. Cette étude pilote a été conçue afin d'étudier si des échantillons d'urine, qui sont beaucoup plus faciles à obtenir, pourraient être utilisés à cet effet plutôt que des échantillons de sérum. Méthodes : Quatre-vingt-seize patients consécutifs admis pour traumatisme crânien ont été inclus dans l'étude. Cinquante-quatre patients ont été exclus de l'étude, la plupart du temps à cause de la présence d'autres traumatismes importants. Les niveaux de S-100β ont été mesurés dans le sérum et l'urine de 42 patients au ...

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Comparison of Clinical, Radiologic, and Serum Marker as Prognostic Factors after Severe Head Injury

Abstract: The serum level of S-100B calculated within 1 to 6 hours of a severe head injury is a useful additional outcome predictor.

Cited by 129 publications

References 16 publications

Significance of Elecsys® S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients

Significance of Elecsys® S100 immunoassay for real-time assessment of traumatic brain damage in multiple trauma patients

Biomarcadores prognósticos no traumatismo crânio-encefálico grave

Can Admission S-100β Predict the Extent of Brain Damage in Head Trauma Patients?

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