Comparison of Clinicopathological Characteristics of BRCA1 and BRCA2 Carriers with Breast Cancer: The Role of Ki-67 Index

Abstract

91One in 8 women in the community are predisposed to develop breast cancer, and this risk significantly escalates in women with a family history of breast carcinoma. 1,2 Approximately, 10% of breast cancers are hereditary, and mutation in the breast cancer (BRCA) gene is one of the best-known mutations associated with breast cancer. [2][3][4][5] The factors that increase the chances of a BRCA mutation in breast cancer include young age (<40 years), triple-negative tumors, male gender, family history, ovarian cancer, and bilateral breast cancer. 6 Currently, BRCA muta-