Comparison of CO2-rebreathing and direct Fick methods for determining cardiac output.

Muiesan, G; Sorbini, C. A.; Solinas, E; Grassi, Vittorio; Casucci, G; Petz, E

doi:10.1152/jappl.1968.24.3.424

Cited by 59 publications

(27 citation statements)

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“…38 This combination has been found to give highly reproducible results (coecient of variation 5.7%) during submaximal exercise in healthy individuals. 20 The results are also in agreement with the results obtained by the direct Fick method 39 and the dye dilution method. 40 However, since only limited data is available for establishing the validity of indirect methods in able-bodied individuals, and no data is available in tetraplegic subjects, it is important to be aware of the assumptions and potential errors that may occur when using these techniques.…”

Section: Discussionsupporting

confidence: 85%

Improved work capacity but unchanged peak oxygen uptake during primary rehabilitation in tetraplegic patients

Hjeltnes

Wallberg-Henriksson

1998

Spinal Cord

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Individuals with cervical spinal cord lesions are characterised by markedly decreased aerobic capacity, accompanied by increased risk of developing cardiovascular disease. The aim of this study was to evaluate the eects of a primary rehabilitation programme that included three sessions of arm cycling per week on the endurance capacity in 10 male tetraplegic subjects (injury level C6-C8; eight ASIA-A and two ASIA-B). Peak oxygen uptake (peak VO 2 ) was measured three times (at T1 & 99+10 days after injury, T2 & 2 months after T1, and at T3 & 2 months after T2). Ten paraplegic patients admitted to the hospital for primary rehabilitation served as controls. In the tetraplegic patients, mean peak load increased (22+2, 32+5, and 32+7 watt, at T1, T2 and T3 respectively) (P50.01), while mean peak VO 2 did not change during the study (0.78+0.07, 0.86+0.08, and 0.81+0.06 16min 71 , at T1, T2 and T3, respectively) (ns). In contrast peak VO 2 was signi®cantly higher in the paraplegic control group (1.37+0.08, 1.64+0.10 and 1.75+0.08 16min 71 , respectively) (P50.001), and increased signi®cantly during the study period (P50.001). Mean heart rate (HR) and mean stroke volume (SV), measured at corresponding submaximal work loads during the study did not change signi®cantly in the tetraplegic patients. Mean systolic blood pressure (SBP), recorded immediately after peak arm exercise was low at all three tests (93+8, 89+6 and 84+6 mmHg) in the tetraplegic group. However, both muscle strength and`activities of daily life' index improved signi®cantly during the study period. Our results suggest that functional improvement in tetraplegic patients is not necessarily followed by aerobic metabolic improvement. We conclude that more time should be spent on arm endurance training, or training methods which activate larger muscle groups and/or increases blood pressure.

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Section: Discussionsupporting

confidence: 85%

Improved work capacity but unchanged peak oxygen uptake during primary rehabilitation in tetraplegic patients

Hjeltnes

Wallberg-Henriksson

1998

Spinal Cord

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“…CO assessed by the indirect Fick method shows good correlation with results obtained by thermodilution at rest in patients with normal left ventricular function (Muiesan, Sorbini, Solinas, Grassi, Casucci & Petz, 1968;Cowley, Stainer, Murphy, Murphy & Hampton, 1986) and with left ventricular failure (Cowley et al 1986). In addition, the indirect Fick method has been used to demonstrate a rise in CO after a meal (Cowley et al 1986;Sidery, Macdonald, Cowley & Fullwood, 1991).…”

Section: Non-invasivementioning

confidence: 66%

The cardiovascular responses to feeding in man

Kearney¹,

Cowley²,

Macdonald³

1995

Experimental Physiology

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“…One is the extrapolation method of DEFARES et al (1961), and the other the plateau method of COLLIER (1956). MUIESAN et al (1968) reported that good agreement was observed between both ox-PVCO2 values. However, GoDFREY and WOLF (1972) reported that the plateau method gave several Torr higher ox-PVco2 values than the extrapolation method.…”

Section: Discussionmentioning

confidence: 66%

A new indirect method for measuring arteriovenous O2 content difference and cardiac output from O2 and CO2 concentrations by rebreathing air.

et al. 1984

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A new indirect method for measuring the arteriovenous 02 content difference (avDo 2) was developed. The avDo 2 was calculated by dividing the gradient of the C02 dissociation curve by that of a gas exchange ratio against Pco2. The latter slope was obtained from 02 and C02 concentrations in rebreathing air. The validity of the method was tested preliminarily in human subjects by comparing the cardiac output calculated from avDo 2 and 02 uptake (o2) with that measured hitherto by other authors, and then in dogs by comparing the calculated avDo, with the measured value. In the dog experiments, the rebreathing was performed 7 times in each of 7 dogs. Immediately after the rebreathing arterial and mixed venous blood were sampled and analyzed for avDo2. For each rebreathing period the avDo, was calculated by using the C02 dissociation curve obtained in the individual dogs. The correlation coefficient between the measured and calculated avDo2 was 0.87, demonstrating reasonable validity of the method. The Vo2 was further measured from the time interval during which a known amount of pure 02 was consumed. Then, the cardiac output was calculated by dividing the Vo2 by the measured and calculated avDo2. The correlation coefficient between the respective cardiac output values was 0.88, indicating the reliability of using the calculated avDo 2.

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Comparison of CO2-rebreathing and direct Fick methods for determining cardiac output.

Cited by 59 publications

References 0 publications

Improved work capacity but unchanged peak oxygen uptake during primary rehabilitation in tetraplegic patients

Improved work capacity but unchanged peak oxygen uptake during primary rehabilitation in tetraplegic patients

The cardiovascular responses to feeding in man

A new indirect method for measuring arteriovenous O2 content difference and cardiac output from O2 and CO2 concentrations by rebreathing air.

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