Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis

Liu, H.; Steensel, S. van; Gielen, M J C A M; Vercoulen, Timon F. G.; Melenhorst, Jarno; Winkens, Björn; Bouvy, Nicole D.

doi:10.1007/s10029-019-02071-y

Cited by 13 publications

(6 citation statements)

References 43 publications

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“…There is a great variability as for the polymers that make up the meshes (porosity, weight, pore shape, biomechanical properties, and fixation), and type of implant, models of defects induced in the abdominal wall, types of animal, types of inflammation, and fibroplasia scores intended for assessing the mesh incorporation process 27 , 28 . This implies technical limitations for comparing experimental studies using meshes to repair induced abdominal wall defects 27 , 29 , 30 . Such heterogeneity in the design of studies and the impossibility of carrying them out in full in human beings impose a limitation to the extrapolation of results and conclusions to the clinical scenario.…”

Section: Discussionmentioning

confidence: 99%

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

et al. 2021

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Purpose To compare tissue inflammatory response, foreign body reaction, fibroplasia, and proportion of type I/III collagen between closure of abdominal wall aponeurosis using polyglactin suture and intraperitoneal implant of polypropylene, polypropylene/polyglecaprone, and polyester/porcine collagen meshes to repair defects in the abdominal wall of rats. Methods Forty Wistar rats were placed in four groups, ten animals each, for the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone, and polyester/porcine collagen meshes or suture with polyglactin (sham) after creation of defect in the abdominal wall. Twenty-one days later, histological analysis was performed after staining with hematoxylin-eosin and picrosirius red. Results The groups with meshes had a higher inflammation score (p < 0.05) and higher number of gigantocytes (p < 0.05) than the sham group, which had a better fibroplasia with a higher proportion of type I/III collagen than the tissue separating meshes (p < 0.05). There were no statistically significant differences between the three groups with meshes. Conclusions The intraperitoneal implant of polypropylene/polyglecaprone and polyester/porcine collagen meshes determined a more intense tissue inflammatory response with exuberant foreign body reaction, immature fibroplasia and low tissue proportion of type I/III collagen compared to suture with polyglactin of abdominal aponeurosis. However, there were no significant differences in relation to the polypropylene mesh group.

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Section: Discussionmentioning

confidence: 99%

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

et al. 2021

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“…The second type of mesh was a polyethylene terephthalate (PET) multifilament textile without barrier. The PET was used as a positive control for the development of soft tissue visceral attachment [12,15] to the mesh. Tissue attachments was induced , using a caecal abrasion and a peritoneal defect model previously described [12,13].…”

Section: Methodsmentioning

confidence: 99%

Can magnetisation transfer magnetic resonance imaging help for the follow-up of synthetic hernia composite meshes fate? A pilot study

Franconi

Lefranc

Radlovic

et al. 2022

Magn Reson Mater Phy

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Purpose:This study aims at evaluating the non-invasive Magnetic Resonance Imaging (MRI) technic to visualize a synthetic composite hernia mesh using a rodent model and to document the integration of this device over 4 months. Methods:Uncoated polyethylene terephthalate mesh and synthetic composite mesh-faced on the visceral side with a chemically engineered layer of copolymer of glycolide, caprolactone, trimethylene carbonate, and lactide to minimize tissue attachment-were placed intraperitoneally in rats, facing the caecum previously scraped to promote petechial bleeding and subsequent adhesions. Meshes fate follow-up was performed 4, 10, and 16-weeks post-implantation using a rodent dedicated high field MRI. Magnetization transfer (MT) images were acquired, associated with pneumoperitonealMRI performed after intraperitoneal injection of 8 mL gas to induce mechanical stress on the abdominal wall. Results:Uncoated meshes were clearly visible using both T2-weighted and MT imaging during the whole study while composite meshes conspicuity was not so evident on T2-weighted MRI and could be improved using MT imaging. Adhesions and collagen infiltration were massive for the uncoated meshes as expected. On the contrary, composite meshes showed very limited adhesion, and, if any, occurring at the edge of the mesh, starting at the fixation points. Conclusions:Magnetization transfer imaging allows to detect mesh integration and, associated with pneumoperitoneum, was able to probe the effective minimizing effect of the synthetic polymeric barrier on visceral attachments. However, magnetization transfer imaging could not unambiguously allow the visualization of the mesh through the polymeric barrier.

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“…Це, в свою чергу, може покращити віддалені результати хірургічного лікування гриж. Для практичної герніології є надзвичайно важливим завданням адгезивної взаємодії новоутвореної сполучної тканини з матеріалом сіток [18].…”

Section: обговорення результатів дослідженняunclassified

The Effect of a Polypropylene Implant Treated With Thyrothricin on the Hypogastric Tissues of the Abdominal Wall in Rats

Kudriavtsev,

Savosko,

Kryshen

et al. 2024

Act. Probl. of the Modern Med.

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Introduction. The study of tissue reactions to the placement of polymeric materials (polypropylene mesh), used for the treatment of hernias, remains relevant. The paper examines the hypothesis regarding the existence of certain differences in tissue reactions to polypropylene implants without and with treatment of the latter with an antimicrobial agent. Objective of this study is to investigate the reaction of the tissues of the peritoneum and the muscle-aponeurotic layer of the abdominal wall to a polypropylene implant treated with thyrothricin, used for the treatment of complicated variants of inguinal hernias. Materials and methods. Experimental studies were conducted on laboratory sexually mature male Wistar rats. Experimental animals made up 4 groups of 5 animals each. The 1st group included control animals (intact). In the rats of the 2nd group, a defect of the abdominal wall of the hypogastric region was surgically modeled. In the animals of the 3rd experimental group, after modeling the defect of the abdominal wall, a polypropylene mesh implant was placed between the peritoneum and the inner leaf of the aponeurosis of the rectus abdominis muscles. The 4th experimental group consisted of animals in which the polypropylene implant was additionally treated with a thyrothricin solution. Results. During the experimental study, the integration of tissue elements of the peritoneal walls and the muscle-aponeurotic layer of the abdominal wall with the material of polypropylene meshes was revealed. Active processes of collagenogenesis were observed in the boundary zones and the area of integration with the implant, as well as pronounced manifestations of vascularization of the newly formed connective tissue. The morphological features of the connective tissue formed in the area and around intact implants and meshes treated with thyrothricin did not significantly differ from each other, but significantly prevailed over the condition of the tissues in intact animals. No particular difference between the above-mentioned changes in the tissues of animals of the 3rd and 4th groups was found. Conclusion. The obtained results indicate positive biocompatibility of body tissues and polypropylene implants. There is no negative effect of polypropylene nets treated with thyrothricin on body tissues and their regenerative potential.

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Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis

Cited by 13 publications

References 43 publications

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

Can magnetisation transfer magnetic resonance imaging help for the follow-up of synthetic hernia composite meshes fate? A pilot study

The Effect of a Polypropylene Implant Treated With Thyrothricin on the Hypogastric Tissues of the Abdominal Wall in Rats

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