Comparison of Cognitive Parameters between Bilateral and Unilateral Hippocampal Sclerosis

En, Vanli Yavuz; Bılgıç, Bilge; Matur, Zeliha; Bebek, Nerses; Gürses, Candan; Gökyiğit, Ayşen; Öktem, Öget; Baykan, Betül

doi:10.5152/npa.2016.14862

Cited by 6 publications

(2 citation statements)

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“…In our study that compared cognitive findings in patients having bilateral HS with those having unilateral HS, we found a significant difference in terms of verbal memory involvement among the patients. Besides, we showed that there is no difference in terms of visual memory decline (5). We also determined that mental retardation was frequent in patients with voltage-gated potassium channel antibodies in our large HS cohort screened for various neuronal autoantibodies.…”

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confidence: 71%

Neuronal Autoantibodies Call for Attention in Epilepsy

Yavuz

Eki̇zoğlu

2017

Arch Neuropsychiatr

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The concept of autoimmune epilepsy has gained considerable interest over the last few years. After the detection of a plethora of antibodies in patients with acute and established epilepsy, prospective cohorts started investigating factors of inflammation. In a recent report, Dubey et al. reported neurological autoantibodies (NAAs) among patients with epilepsy of unknown etiology. They investigated 112 patients for various NAAs including anti-GAD and found NAAs in 34.8% of the cases (1). It is most notable that our recent studies showed very similar antibody prevalence and clinical associations as those of Dubey et al. We investigated identical patient groups, namely, focal epilepsy of unknown cause and mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) 3 years ago, and published our results of 81 patients (2). We found antibodies to the glycine receptor (GLY-R) in 6.2% of our patients, CASPR2 in 4.9%, NMDAR in 2.5%, and VGKC-complex in 2.5% (2).

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confidence: 71%

Neuronal Autoantibodies Call for Attention in Epilepsy

Yavuz

Eki̇zoğlu

2017

Arch Neuropsychiatr

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“…Details of neuropsychological results are published elsewhere. 19 Drug resistance was defined according to the criteria published by Kwan et al 20 For all operated patients, postoperative follow-up duration and duration of seizure freedom were investigated if present. The prognosis of the patients was classified according to the Engel classification.…”

Section: Clinical Data Collectionmentioning

confidence: 99%

How Different Are the Patients With Bilateral Hippocampal Sclerosis From the Unilateral Ones Clinically?

et al. 2016

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Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy

Sitoh,

Weintrob,

Anderson

et al. 2024

Epilepsia Open

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ObjectiveLeft hippocampal sclerosis (HS) is associated with verbal‐specific memory impairment. This association is well established for word list learning tasks, and there is some evidence that this may also be relevant to verbal paired associates learning (PAL), though the evidence is limited. We aimed to evaluate the utility of verbal PAL as a marker for left HS, compare this with word list learning, and derive cutoff scores to facilitate clinical application.MethodsRetrospective analysis of Rey Auditory Verbal Learning Test (RAVLT) and PAL scores obtained from 116 surgically naïve temporal lobe epilepsy patients with HS (14 bilateral, 57 left, 45 right; range of N across test indices: 77–110).ResultsRelative to right HS, left HS and bilateral HS were associated with poorer performance on PAL Hard Pairs (p < 0.001) and all RAVLT indices (p < 0.001), with performance comparable in left HS and bilateral HS (p > 0.05). PAL Hard Pairs and all RAVLT indices displayed acceptable discriminatory ability (AUC > 0.70) in classifying left‐sided HS (unilateral left or bilateral HS), with RAVLT delayed recall the strongest predictor (AUC = 0.87; PAL Hard Pairs Learning and Delay = 0.80 and 0.83, respectively). Optimal cutoff scores for left‐sided HS classification were generated.SignificanceAlthough the RAVLT delayed recall was the strongest predictor of left‐sided HS, PAL Hard Pairs also demonstrated excellent discriminatory capacity, offering an additional cognitive marker of left hippocampal integrity to complement word list learning in clinical assessments.Plain Language StatementThe results of the study show that the ability to learn unrelated pairs of words (e.g., “silver”–“run”) is compromised in the setting of epilepsy with left‐sided hippocampal sclerosis (HS), be it unilateral left HS or bilateral HS. The ability of unrelated word pair learning to discriminate left vs. right HS was comparable to word list learning, a task with demonstrated sensitivity to left HS. Our results suggest that the ability to learn unrelated pairs of words provides another useful marker of left‐sided hippocampal compromise in epilepsy. We provide cutoff scores to facilitate clinical interpretation.

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Comparison of Cognitive Parameters between Bilateral and Unilateral Hippocampal Sclerosis

Abstract: Our study revealed that bilateral involvement of the hippocampi was correlated with a poor cognitive performance. Retrieval failure, rather than a total recall problem, in the memory of the patients resembles a more diffuse involvement not only limited to limbic structures.

Cited by 6 publications

References 19 publications

Neuronal Autoantibodies Call for Attention in Epilepsy

Neuronal Autoantibodies Call for Attention in Epilepsy

How Different Are the Patients With Bilateral Hippocampal Sclerosis From the Unilateral Ones Clinically?

Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy

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