Comparison of common data elements from the Managing Epilepsy Well (MEW) Network integrated database and a well-characterized sample with nonepileptic seizures

The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE‐BD) project: Understanding older‐age bipolar disorder by combining multiple datasets

“…A GAGE-BD Steering Committee will be composed of members of the OABD taskforce who contribute data and other relevant stakeholders. Procedures and templates to help coordinate and organize workflow (eg, data analysis proposal forms, authorship agreement, definitions of personal health information (PHI) to ensure that GAGE-BD contains only de-identified data) will be adapted from materials used by members of the study team in creating a similar integrated database that has [15][16][17][18][19][20] Building upon preliminary work with the MEW Network and with the AGE-BD effort, the GAGE-BD project core team (MS, LT, AD, SR) will assist international investigators to obtain the necessary local regulatory approvals, complete data sharing agreements, and to prepare their data for upload to the GAGE-BD collection. Additional Stage 1 activities will include convening the Steering Committee, Institutional Review Board (IRB) approval of the overall project, finalization of analysis approach to the initial research questions, and generation of additional exploratory analysis questions.…”

Youth With Psychogenic Non-Syncopal Collapse Have More Somatic and Psychiatric Symptoms and Lower Perceptions of Peer Relationships Than Youth With Syncope

“…The higher number of somatic complaints and psychiatric diagnoses among patients with PNSC parallels the PNES literature. [14][15][16][17][18][19][20][21][22][23] In addition to increased somatic complaints, patients with PNES similarly have been shown to have more (non-PNES) functional neurological symptom disorders when compared with patients with epileptic seizures. 14 The presence of chronic pain and the diagnosis of fibromyalgia each independently predicted PNES among adults who presented with refractory seizures.…”

“…Pediatric and adult patients with PNES have more somatic complaints, more psychiatric symptoms, poorer quality of life, and more non-PNES functional neurological (conversion) disorders when compared with patients with epilepsy. [14][15][16][17][18][19][20][21][22][23] To broaden our understanding of the biopsychosocial profile that increases an individual's vulnerability to PNSC specifically and to functional neurological symptoms more generally, the present study compared somatic and psychiatric symptoms, previous medical diagnoses and testing, medical referrals, prescribed medicines, and patient self-ratings of anxiety, depression, and peer relationships between patients diagnosed with PNSC and patients diagnosed with neurally mediated syncope. To optimize the PNSC diagnostic rate, a prolonged head-upright tilt-table protocol was used and additional testing was performed when patients had atypical responses during tiltinduced syncope or atypical symptoms when tilt-table testing was otherwise normal.…”

Psychogenic non-epileptic seizures in Japan: Trends in prevalence, delay in diagnosis, and frequency of hospital visits

“…Therefore, a definitive diagnosis of PNES is crucial to allow prescription of the appropriate treatment [10]. Monitoring of the ictus using a video electroencephalogram (EEG), a relatively costly and timeconsuming examination, is considered the gold standard for distinguishing PNES from epilepsy [11][12][13][14][15][16][17][18]. Treatments for PNES, such as cognitive behavioral intervention, education, psychotherapy, and communication and family therapy, are thought to be effective.…”