Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS

Hansen, Stine Lund; Dalsgaard, Petur Weihe; Línnet, Kristían; Rasmussen, Brian Schou

doi:10.1093/jat/bkac011

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…A forensic panel which includes several medications commonly used in psychiatry including antipsychotics, was run, but additional compounds were tested when information was available indicating that the patient was taking a medication that was not included in the panel. Toxicological screening for antipsychotics in blood and brain produce highly consistent results [37], although concentrations tend to be higher in brain compared to blood [38,39]. Therefore, when a negative result for antipsychotics was detected in blood, the tests were repeated in cerebellar tissue.…”

Section: Toxicology Screeningmentioning

confidence: 99%

Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia

et al. 2023

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Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of differentially expressed genes. However, the extent to which these gene expression changes reflect antipsychotic drug (APD) exposure remains uncertain. We compared differential gene expression in the prefrontal cortex of SCZ patients who tested positive for APDs at the time of death with SCZ patients who did not. APD exposure was associated with numerous changes in the brain transcriptome, especially among SCZ patients on atypical APDs. Brain transcriptome data from macaques chronically treated with APDs showed that APDs affect the expression of many functionally relevant genes, some of which show expression changes in the same directions as those observed in SCZ. Co-expression modules enriched for synaptic function showed convergent patterns between SCZ and some of the APD effects, while those associated with inflammation and glucose metabolism exhibited predominantly divergent patterns between SCZ and APD effects. In contrast, major cell-type shifts inferred in SCZ were primarily unaffected by APD use. These results show that APDs may confound SCZ-associated gene expression changes in postmortem brain tissue. Disentangling these effects will help identify causal genes and improve our neurobiological understanding of SCZ.

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Section: Toxicology Screeningmentioning

confidence: 99%

Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia

et al. 2023

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“…Quantitative measurements of drugs in body fluids are helpful in monitoring the use of antidotes and extracorporal clearance of patients in the clinic [ 4 , 5 , 6 , 7 , 8 ]. Additionally, reports on quantitative measurements of parent drug and metabolites in the body fluids of the deceased can enhance our knowledge of postmortal redistribution and ultimately aid in establishing a potential toxicological cause of death [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%