Comparison of confocal scanning laser ophthalmoscopy, scanning laser polarimetry and optical coherence tomography to discriminate ocular hypertension and glaucoma at an early stage

Kanamori, Akira; Nagai-Kusuhara, Azusa; Escaño, M.F.; Maeda, Hidetaka; Nakamura, Makoto; Negi, Akira

doi:10.1007/s00417-005-0029-0

Cited by 90 publications

(58 citation statements)

References 27 publications

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“…The simultaneous acquisition of the parameters makes the measurements more robust against possible errors caused, for example, by motion artefacts or registration errors that can occur between separate measurements. All three parameters are believed to be an early indicator for glaucoma, [34][35][36] which possibly makes PS-OCT a valuable tool for future glaucoma diagnostics.…”

Section: Discussionmentioning

confidence: 99%

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Zotter

Pircher

Götzinger

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We presented a novel polarization sensitive optical coherence tomography (PS-OCT) system for measuring retinal nerve fiber layer (RNFL) birefringence, retardation, and thickness, and report on the repeatability of acquiring these quantities. METHODS.A new PS-OCT system, measuring at 840 nm, was developed that supports scan angles of up to 408 3 408 with an A-scan rate of 70 kHz. To test the performance and reproducibility, we measured 10 eyes of 5 healthy human volunteers five times each. All volunteers were imaged further with scanning laser polarimetry (SLP). The obtained RNFL birefringence, retardation, and thickness maps were averaged, and standard deviation maps were calculated. For quantitative comparison between the new PS-OCT and SLP, a circumpapillary evaluation within 2 annular segments (superior and inferior to the optic disc) was performed.RESULTS. High quality RNFL birefringence, retardation, and thickness maps were obtained. Within the superior and inferior segments, the mean retardation for individual eyes ranged from 208 to 28.98 and 17.28 to 28.28, respectively. The quadrant precision over the 5 consecutive measurements for each subject, calculated for the average retardation obtained within the superior and inferior quadrants ranged from 0.168 to 0.698. The mean birefringence ranged from 0.1068/lm to 0.1418/lm superior and 0.1018/lm to 0.1358/lm inferior, with a quadrant precision of 0.0018/lm to 0.0078/lm. The mean RNFL thickness varied from 114 to 150 lm superior, and 111 to 140.9 lm inferior (quadrant precision ranged from 3.6 to 11.9 lm). CONCLUSIONS.The new PS-OCT system showed high image quality and reproducibility, and, therefore, might be a valuable tool for glaucoma diagnosis. (Invest Ophthalmol Vis Sci. 2013; 54:72-84)

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Section: Discussionmentioning

confidence: 99%

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Zotter

Pircher

Götzinger

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…En el presente estudio hemos demostrado, al igual que diversos estudios anteriores, que los pará-metros analizados por el GDx-VCC son útiles para discriminar entre sujetos normales y glaucomatosos con defectos leves o moderados en la PA (6,7,(17)(18)(19)(20)(21). La mayoría de los parámetros presentaron diferencias significativas entre sujetos normales o hipertensos y glaucomatosos, no encontrándose para ningún parámetro diferencias entre controles e hipertensos oculares.…”

Section: Discussionunclassified

Capacidad diagnóstica del GDx VCC para el diagnóstico del glaucoma

Borque

Ferreras

Polo

et al. 2008

Arch Soc Esp Oftalmol

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RESUMENObjetivo: Evaluar la capacidad diagnóstica de los distintos parámetros que ofrece el GDx VCC para discriminar entre ojos sanos y glaucomatosos. Material y métodos: Se seleccionaron de forma prospectiva y consecutiva 417 ojos de 417 pacientes. Fueron divididos en 60 controles, 218 hipertensos oculares, 68 glaucomas preperimétricos y 71 glaucomas según la presión intraocular, la morfología papilar y los resultados en la perimetría automatizada convencional A todos ellos se les realizó una polarimetría láser con el GDx VCC. Se compararon los parámetros de la capa de fibras nerviosas de la retina (CFNR) del GDx-VCC entre los grupos. Se calcularon las curvas ROC entre el grupo normal y de glaucomas. Se consideraron como mejores parámetros aquellos con mejor área bajo la curva ROC y el mejor balance de sensibilidad/especificidad. Resultados: La mayoría de los parámetros del GDx-VCC mostraron diferencias entre el grupo de glaucomas y el resto de los grupos. Algunos pará-metros fueron también diferentes al comparar el grupo normal y el de glaucomas preperimétricos. El mejor de ellos fue el indicador de fibras nerviosas (NFI; área bajo la curva ROC: 0,876). El NFI, el área inferior normalizada y el área superior norma-ARTÍCULO ORIGINAL ABSTRACT Purpose: To assess the diagnostic ability of scanning laser polarimetry (GDx VCC) to differentiate between normal and glaucomatous eyes. Methods: 417 eyes of 417 consecutive subjects were prospectively selected. They were classified into 60 healthy controls, 218 ocular hypertensive eyes, 68 glaucoma suspects, and 71 glaucomatous eyes, depending on intraocular pressure, optic nerve head morphology and standard automated perimetry results. All underwent a scanning laser polarimetry with the GDx VCC. Retinal nerve fiber layer (RNFL) parameters of the GDx-VCC were compared among the four groups. Receiver operating characteristic (ROC) curves were plotted between normal and glaucomatous eyes. The best parameters were defined according to the area under the ROC curve and the best sensitivity/specificity balance. Results: Most parameters of GDx-VCC exhibited differences between the glaucoma group and the rest of the groups. Some parameters were also different between healthy patients and glaucoma suspects. The best parameter was the nerve fiber indicator (NFI; area under the ROC curve: 0.876). NFI, superior normalized area, and inferior normalized area yielded the highest sensitivities at 85% and 90% fixed specificity.

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“…Glaucoma is an eye disease in which the optic nerve suffers damage (Chung & Guan, 2006;Eckert, 2010;Herdener & Pache, 2007;Hoffmann & Schulze, 2009;Juzych et al, 2004;Kanamori et al, 2006;Keicher & Stoffelns, 2010;Ngoi et al, 2005;Preußner et al, 2010;Schlote et al, 2008;Wilmsmeyer et al, 2006). It causes permanently decay of vision and if it is untreated it progresses to complete blindness.…”

Section: Application Of Lasers In Ophthalmologymentioning

confidence: 99%

Lasers in Ophthalmology

Zdybel¹,

Pilawa²,

Krzeszewska-Zaręba³

2012

Advances in Ophthalmology

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Comparison of confocal scanning laser ophthalmoscopy, scanning laser polarimetry and optical coherence tomography to discriminate ocular hypertension and glaucoma at an early stage

Abstract: Three instruments were useful in identifying GS and EG eyes. For glaucomatous eyes with or without early visual field defects, SLP and OCT performed similarly or had better discriminating abilities compared with CSLO.

Cited by 90 publications

References 27 publications

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

Capacidad diagnóstica del GDx VCC para el diagnóstico del glaucoma

Lasers in Ophthalmology

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