Comparison of contact endoscopy and frozen section histopathology in the intra-operative diagnosis of laryngeal pathology

Cikojević, Draško; Glunčić, Ivo; Pešutić-Pisac, Valdi

doi:10.1017/s0022215107000539

Cited by 41 publications

(43 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Specific cellular epithelial patterns in different disorders have been observed, namely, chronic laryngitis, keratosis, dysplasia, papilloma and malignant tumor. The need of having recourse to the general anesthesia and the difficulties of assessing the epithelium in case of major keratosis are the limiting factors of this technique [15,16]. Lugol chromoendoscopy enhances the detection rate of high-risk lesions with dysplasia or carcinoma in situ in large unstained lesions.…”

Section: Discussionmentioning

confidence: 99%

Pharyngo-laryngeal examination with the narrow band imaging technology: early experience

Irjala

Matar²,

Remacle³

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The prognosis of cancer patients is highly dependent on the time of diagnosis. Early, stage 1 disease is often curable whereas late stage diseases are usually beyond curable treatments. Therefore, new diagnostic tools for malignancies of the upper aerodigestive tract are developed all the time and narrow band imaging (NBI) is one of these new options for early diagnostics. In this paper, we describe the implementation of NBI technique in our institution. During the first 6 weeks we used NBI to examine 73 patients with different types of pharyngeal or laryngeal problems. Most of the patients (77%) were on follow-up visits after earlier malignant disease. In our series we had 11 NBI-positive patients and the histological diagnosis was carcinoma or dysplasia among 10 of these. Among the NBI negative patients we found four carcinomas. It is notable that NBI affected the decision of a biopsy procedure in three patients, with final diagnosis of dysplasia or carcinoma. In conclusion, we find NBI useful in the diagnostics of malignancies of the upper aerodigestive tract. This is a useful tool in improving the accuracy of the diagnostics. However, it still takes an experienced clinician and a learning curve can be expected.

show abstract

Section: Discussionmentioning

confidence: 99%

Pharyngo-laryngeal examination with the narrow band imaging technology: early experience

Irjala

Matar²,

Remacle³

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…In fact, expansion of squamous epithelium from the vocal fold edges to the areas of columnar epithelium can be clearly visualized by contact endoscopy; hyperkeratosis (i.e. deposits of anuclear cells on the epithelial surface) or leukoplakia are clearly observed on contact endoscopy, and the grade of dysplasia that may occur in association with them is generally indicated by the impaired nucleus/cytoplasm ratio, nuclear hyperchromasia, and variation in the number and appearance of the nucleoli (107). False negative results may occur in case of incomplete penetration of the stain throughout the epithelial thickness thus hindering the identification of the grade of dysplasia; in this setting the presence of secretion decreases stain penetration, while the secretion itself precludes any direct contact between the endoscope and the mucosa epithelium.…”

mentioning

confidence: 99%

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Mannelli

Cecconi

Gallo

2016

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Abstract.Background: Multi-step cancerogenesis guides laryngeal cancer onset and it includes a wide variety of pre-cancerous lesions that are macroscopically challenging to identify and distinguish from initial cancerous foci. Since the treatment of laryngeal cancer and its precursor lesions has a great impact on important laryngeal basic functions, early detection and preoperative assessment are important for a curative and function-preserving therapy. Nowadays, despite the high number of more advanced diagnostic techniques and methods, unfortunately, it is not uncommon for different clinicians to use different nomenclature or to identify different stage for the same laryngeal lesion. From these observations, it is obvious that an instrument offering the possibility to detect precancerous lesions, early cancerous lesions, and satellite foci or second primaries would be the key to improving management and outcome in laryngeal patients. Object. Different modalities of diagnostic techniques of laryngeal lesions exist. Rather than difference between benign and obvious malignant diseases, more difficult is to detect the presence of precancerous epithelial alterations. Not all tests achieve the same diagnostic accuracy, hence this meta-analysis of literature aimed to synthesize the validity of each single diagnostic technique in identifying and staging laryngeal disease. Methods: A systematic review of literature was led searching for articles mentioning the following terms including their various combinations to maximize the yield: larynx, laryngeal precancerous lesions, laryngeal cancer, white light (WL) endoscopy, stroboscopy, contact endoscopy (CE), autofluorescence (AF), ultrasound (US), narrow band imaging (NBI), computed axial tomography (CAT), magnetic resonance imaging (MRI), positron emission tomography (PET), CAT/PET. Then, a quantitative analysis was carried on for paper published after 2005 onward, reporting a minumun series of 10 patients each study, declaring sensitivity and specificity of each diagnostic system. Results: The search identified 7215 publications, of which 3616 published after 2005, with a final results of a total of 214 articles stratified and included by our selection criteria. 42 out of 214 articles were selected for quantitative synthesis. 25 out of 41 studies had a quality score of ≥ 6 (good), 16 presented a score between 4 and 5 (fair). While objections can be raised about the pooling of different diagnostic procedures under the same group and the high level of heterogeneity in the meta-analyses, the inclusion of over 4400 laryngeal lesions makes the results fairly robust. Conclusions: A comprehensive overview of the most recent advances in laryngeal imaging technology combined with all of the information needed to interpret findings and successfully manage patients with voice disorders can be found herein. With these data, clinicians can riskstratify patients and select proper examination modalities in order to provide appropriate care. Moreover, study limitations, together with p...

show abstract

“…[30,31] They were able to visualize and diagnose laryngeal mucosal pathology from the magnification of vocal fold epithelium and microvasculature during microlaryngoscopy after staining the vocal cords with methylene blue dye.…”

Section: Resultsmentioning

confidence: 99%

An update on light-based technologies and fluorescent imaging in oral cancer detection

Gupta¹

2017

Oncobiology and Targets

View full text Add to dashboard Cite

Oral cancer is a potentially fatal disease that constitutes an important portion of tumors of head and neck region. More than 90% of oral cancers are oral squamous cell carcinomas (OSCC). Regardless of the fact that the oral cavity is easily accessible to the accumulation of carcinogens, most oral cancers are typically detected at an advanced stage leading to lower survival rate among subjects. Therefore, early detection of the oral cancer and its precursor lesions may be the most effective means to improve prognosis and treatment in most patients. One of the emerging technologies is the use of optical methods to capture the molecular changes at high-resolution to improve the detection capability of early stage disease. Optical diagnosis techniques when compared with traditional approaches such as vital staining, biopsy has many advantages such as objectivity, speed, and cost. Moreover, these incorporate particularly noninvasive methods of oral cancer detection. The present article highlights various optical methods and their role in oral cancer detection.

show abstract

Comparison of contact endoscopy and frozen section histopathology in the intra-operative diagnosis of laryngeal pathology

Cited by 41 publications

References 13 publications

Pharyngo-laryngeal examination with the narrow band imaging technology: early experience

Pharyngo-laryngeal examination with the narrow band imaging technology: early experience

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

An update on light-based technologies and fluorescent imaging in oral cancer detection

Contact Info

Product

Resources

About