Comparison of contact lens–assisted and transepithelial corneal crosslinking with standard epithelium-off crosslinking for progressive keratoconus: 24-month clinical results

Malhotra, Chintan; Gupta, Bindiya; Jain, Arun Kumar; Dhar, Supriya; Gupta, Amit; Balyan, Monika

doi:10.1097/j.jcrs.0000000000000732

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…In a study evaluating 2-year follow-up, significant changes were observed in the CACXL groups in Kmax, simulated keratometry and SE, with larger reduction in Kmax compared with standard epi-off CXL, although this could be attributable to higher baseline Kmax in the CACXL group. 55 No complications were observed.…”

Section: Contact Lens-assisted and Smile Lenticule-assisted CXLmentioning

confidence: 89%

“…A review by Srivatsa et al54 highlights the safety profile in 4 studies totaling 69 eyes with up to 1-year follow-up, showing no difference in demarcation line depth and endothelial cell density to other CXL protocols. In a study evaluating 2-year follow-up, significant changes were observed in the CACXL groups in Kmax, simulated keratometry and SE, with larger reduction in Kmax compared with standard epi-off CXL, although this could be attributable to higher baseline Kmax in the CACXL group 55. No complications were observed.…”

Section: Contact Lens-assisted and Smile Lenticule-assisted CXLmentioning

confidence: 97%

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Corneal Crosslinking: Present and Future

Angelo¹,

Boptom²,

McGhee³

et al. 2022

Asia-Pacific Journal of Ophthalmology

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Keratoconus is a progressive corneal thinning disorder that can lead to vision loss. In the last 2 decades, corneal crosslinking (CXL) has emerged as an effective method to halt the progression of keratoconus and reduce the number of patients requiring keratoplasty. The procedure has been adopted globally and has evolved to become a part of combination treatments to regularize the cornea and improve visual outcomes. CXL has even been extrapolated in managing other ocular pathologies such as progressive myopia, infectious keratitis, and bullous keratopathy. This review aims to summarize the current role of CXL in keratoconus and its alternative uses, and provide insights into future developments in this fast-developing field.

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Section: Contact Lens-assisted and Smile Lenticule-assisted CXLmentioning

confidence: 89%

Section: Contact Lens-assisted and Smile Lenticule-assisted CXLmentioning

confidence: 97%

Corneal Crosslinking: Present and Future

Angelo¹,

Boptom²,

McGhee³

et al. 2022

Asia-Pacific Journal of Ophthalmology

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“…S. Srivatsa и соавт. подчеркнули профиль безопасности в 4 исследованиях с участием 69 глаз в течение 1 года наблюдения, при этом не было отличий в глубине демаркационной линии и плотности эндотелиальных клеток по сравнению с другими протоколами КРК [30,31]. Кроме того, при разработке КРК в сочетании со SMILE также была предпринята попытка увеличить толщину роговицы путем размещения донорской лентикулы в роговице перед облучением.…”

Section: кросслинкинг в комбинации с контактными линзами и лентикулойunclassified

Clinical Aspects of Corneal Collagen Crosslinking Various Modifications

Yusef,

Khraystin,

Osipyan

et al. 2024

Oftalʹmologiâ

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The review provides information on methods for crosslinking corneal collagen (КРК), from the time of experimental studies and the first clinical observations to the present. Data are presented on the methods and results of CXL various modifications, as well as on possible promising directions for finding ways to improve the technique to improve functional results and reduce possible complications. Research is currently ongoing not only to improve already proven approaches for CXL, but also to search for new combinations and devices.

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Definition of Progressive Keratoconus: A Systematic Review

Henriquez,

Larco,

Izquierdo

2024

Cornea

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Purpose: To identify the definitions used for progressive keratoconus in the literature. Methods: A systematic literature review aimed to identify the definitions used for “progressive keratoconus” in the published articles. A comprehensive search from January 2018 to May 2023 was conducted across Cochrane Library, PubMed, Taylor & Francis, Web of Science, and other bibliographic databases at Oftalmosalud, Lima, Peru. The inclusion criteria were articles including patients with keratoconus without any previous surgical procedure and containing the definition of “progressive keratoconus” or “keratoconus progression” and a sample size greater than 10 eyes. Results: A total of 221 articles were included for analysis. The 3 most frequent parameters to define progression included data from anterior curvature, pachymetry, and refraction used in 97.8% (216/221), 37.6% (83/221), and 32.1% (71/221) of the articles, respectively. Specifically, the most frequent criterion used was maximum keratometry (Kmax), used in 85.5% (189/221) of the articles. Progression was assessed between 6- and 12-month follow-up in 64.7% (143/221) of the articles. Data from posterior cornea were used in only 8.1% (18/221) of the studies. None of the studies included data from the corneal epithelium. Conclusions: The present study demonstrates the lack of unified criteria to define progression of keratoconus and an underutilization of the technology described. It also shows that the single point Kmax measurement is the most commonly used criterion, followed by a change in refractive astigmatism and thinning at the thinnest pachymetric point.

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Comparison of contact lens–assisted and transepithelial corneal crosslinking with standard epithelium-off crosslinking for progressive keratoconus: 24-month clinical results

Abstract: To compare the outcomes of contact lens-assisted corneal crosslinking (CACXL) and transepithelial CXL (TECXL) with standard epithelium-off (epi-off) CXL for progressive keratoconus.

Cited by 4 publications

References 44 publications

Corneal Crosslinking: Present and Future

Corneal Crosslinking: Present and Future

Clinical Aspects of Corneal Collagen Crosslinking Various Modifications

Definition of Progressive Keratoconus: A Systematic Review

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