Comparison of continuous long-term heparin and oral anticoagulant therapy in patients with severe angina pectoris

Hughes, Michelle L.; Mortensen, Frede; Shourie, Leela

doi:10.1016/0002-8703(63)90124-8

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1968

1985

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Cited by 10 publications

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“…Moreover, high doses of heparin provided greater reduction in mortality than oral anticoagulant therapy. 83 Even mini-doses of heparin (5000 to 6000 IU subcutaneously daily) showed a statistically significant advantage over oral anticoagulants, although in this study, the nonrandom allocation of patients could have affected the results. 84 On the other hand, while poorly designed studies supported a beneficial effect of heparin in secondary prevention of myocardial infarction, 8587 two wellcontrolled trials did not show that intermittent heparin therapy was better than a placebo 88 or oral anticoagulants.…”

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confidence: 64%