Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence

Quaia, Emilio; D’Onofrio, Mirko; Palumbo, Alessandro; Rossi, Stefania; Bruni, Stefano; Cova, Maria Assunta

doi:10.1007/s00330-006-0192-7

Cited by 141 publications

(81 citation statements)

References 35 publications

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“…In adults, numerous applications have been assessed and reported in the literature-particularly the use of US-CAs for lesion detection and characterisation in abdominal parenchymal organs (predominantly the liver) [32,[41][42][43][44][45][46][47][48][49][50][51][52]. These reports demonstrate not only a high diagnostic potential and reliability of CE-US, but also a high safety profile of US-CAs; in adults, anaphylactoid reactions have been reported at a low rate of less than 0.002% [53,54].…”

Section: Discussionmentioning

confidence: 99%

Application of a second-generation US contrast agent in infants and children—a European questionnaire-based survey

Riccabona

2012

Pediatr Radiol

100

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Background No US contrast agent (US-CA) is currently licensed for use in children.Objective To survey the off-label use in children of a second-generation US-CA. Materials and methods Questionnaires were e-mailed to European paediatric radiologists, who were asked about their experience with the second-generation US-CA Sonovue® (Bracco, Milan, Italy). Number of examinations per indication and adverse effects were recorded. Examinations were categorised by intravenous or intracavitary use of US-CA. Results Out of 146 respondents, 88 stated that they did not perform contrast-enhanced US in children, but 36 of these (44%) would appreciate paediatric approval. Fortyfive centres reported 5,079 examinations in children (age mean: 2.9 years; range: birth-18 years, M/F: 1/ 2.8). The majority (4,131 [81%] in 29 centres) were intravesical applications. The minority (948 [19%] in 30 centres) were intravenous applications. No adverse effects had been recorded from intravesical use. Six minor adverse effects (skin reaction, unusual taste, hyperventilation) had been recorded after five intravenous studies (0.52%). Conclusion Responses suggest a favourable safety profile of this second-generation US-CA in children. It also demonstrates a demand for such US-CA from paediatric radiologists.

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Section: Discussionmentioning

confidence: 99%

Application of a second-generation US contrast agent in infants and children—a European questionnaire-based survey

Riccabona

2012

Pediatr Radiol

100

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“…In addition, CV values might depend on the organ as some can be more challenging to image such as the liver suffering from respiration artifacts. There is also a limited depth penetration making imaging of deepest regions difficult [50,58] . Finally, some anti-angiogenic treatments mainly involve change in tumor vasculature permeability without tumor flow.…”

Section: Anti-angiogenesis Therapies and Dce-us Imagingmentioning

confidence: 99%

Estimation of intra-operator variability in perfusion parameter measurements using DCE-US

Gauthier¹

2011

WJR

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AIM:To investigate intra-operator variability of semiquantitative perfusion parameters using dynamic contrast-enhanced ultrasonography (DCE-US), following bolus injections of SonoVue ® . METHODS:The in vitro experiments were conducted using three in-house sets up based on pumping a fluid through a phantom placed in a water tank. In the in vivo experiments, B16F10 melanoma cells were xenografted to five nude mice. Both in vitro and in vivo , images were acquired following bolus injections of the ultrasound contrast agent SonoVue ® (Bracco, Milan, Italy) and using a Toshiba Aplio ® ultrasound scanner connected to a 2.9-5.8 MHz linear transducer (PZT, PLT 604AT probe) (Toshiba, Japan) allowing harmonic imaging ("Vascular Recognition Imaging") involving linear raw data. A mathematical model based on the dye-dilution theory was developed by the Gustave Roussy Institute, Villejuif, France and used to evaluate seven perfusion parameters from time-intensity curves. Intra-operator variability analyses were based on determining perfusion parameter coefficients of variation (CV). RESULTS:In vitro , different volumes of SonoVue ® were tested with the three phantoms: intra-operator variability was found to range from 2.33% to 23.72%.In vivo , experiments were performed on tumor tissues and perfusion parameters exhibited values ranging from 1.48% to 29.97%. In addition, the area under the curve (AUC) and the area under the wash-out (AUWO) were two of the parameters of great interest since throughout in vitro and in vivo experiments their variability was lower than 15.79%. CONCLUSION:AUC and AUWO appear to be the most reliable parameters for assessing tumor perfusion using DCE-US as they exhibited the lowest CV values.

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“…Ebenso wurde gezeigt, daß die ComputertomographieUntersuchung des Abdomens bzw. der Leber eine deutlich höhere Sensitivität im Aufdecken von Metastasen aufweist als die Oberbauchsonographie [3,[8][9][10].…”

Section: Präambelunclassified

Empfehlungen zur Nachsorge nach Mammakarzinom

Kubista¹,

Petru²

2007

Senologie - Zeitschrift für Mammadiagnostik und -therapie

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Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence

Abstract: CEUS improved liver metastases diagnosis in comparison with baseline US while it revealed similar diagnostic performance and confidence to contrast-enhanced CT in patients considered suitable for US and with proven or suspected liver metastases at baseline US.

Cited by 141 publications

References 35 publications

Application of a second-generation US contrast agent in infants and children—a European questionnaire-based survey

Application of a second-generation US contrast agent in infants and children—a European questionnaire-based survey

Estimation of intra-operator variability in perfusion parameter measurements using DCE-US

Empfehlungen zur Nachsorge nach Mammakarzinom

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