Comparison of conventional<i>in vitro</i>fertilisation and intracytoplasmic sperm injection outcomes in patients with moderate oligoasthenozoospermia

Shuai, Han-Lin; Ye, Q.; Huang, Yuanhua; Xie, Baoguo

doi:10.1111/and.12291

Cited by 22 publications

(17 citation statements)

References 21 publications

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“…At variance with those results, more recent data on patients of various ages reported comparable or even higher fertilization rates per retrieved oocyte for cIVF than ICSI [9,10,16,25]. The largest population-based cohort study published so far, which included women distributed on a wide age range belonging to couples with non-male factor infertility, resulted in a similar cumulative live birth rate (up to 6 treatment cycles) between cIVF and ICSI [9].…”

Section: Discussionmentioning

confidence: 73%

ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model

Gennarelli¹,

Carosso²,

Canosa³

et al. 2019

JCM

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This study compared the cumulative live birth rates following Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilization (cIVF) in women aged 40 years or more and unexplained infertility. A cohort of 685 women undergoing either autologous conventional IVF or ICSI was retrospectively analyzed. The effects of conventional IVF or ICSI procedure on cumulative pregnancy and live birth rates were evaluated in univariate and in multivariable analysis. In order to reduce potential differences between women undergoing either IVF or ICSI and to obtain unbiased estimation of the treatment effect, propensity score was estimated. ICSI was performed in 307 couples (ICSI group), whereas cIVF was performed in 297 couples (cIVF group), resulting in 45 and 43 live deliveries, respectively. No differences were observed in morphological embryo quality, in the number of cleavage stage embryos, in the number of transferred embryos, and in the number of vitrified embryos. As for the clinical outcome, no differences were observed in pregnancy rate, cumulative pregnancy rate, live birth rate, cumulative live birth rate, and abortion rate. The present results suggest that ICSI is not associated with increased likelihood of a live birth for unexplained, non-male factor infertility, in women aged 40 years or more.

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Section: Discussionmentioning

confidence: 73%

ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model

Gennarelli¹,

Carosso²,

Canosa³

et al. 2019

JCM

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“…Numerous reports have exhibited the promising clinical outcomes in the ICSI treatment of severe infertility, 19 35 36 37 38 whereas there has been a concern if ICSI increases a rate of the birth defects in ICSI conceived children, particularly compared to IVF. It's notable a systematic and two large-scale studies do not exhibit a significant difference in birth defects between ICSI and IVF.…”

Section: Discussionmentioning

confidence: 99%

ICSI treatment of severe male infertility can achieve prospective embryo quality compared with IVF of fertile donor sperm on sibling oocytes

Zheng¹,

Chen²,

Zhao³

et al. 2015

Asian J Androl

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Azoospermia, cryptozoospermia and necrospermia can markedly decrease the ability of males to achieve pregnancy in fertile females. However, patients with these severe conditions still have the option to be treated by intracytoplasmic sperm injection (ICSI) to become biological fathers. This study analyzed the fertilization ability and the developmental viabilities of the derived embryos after ICSI treatment of the sperm from these patients compared with in vitro fertilization (IVF) treatment of the proven-fertile donor sperm on sibling oocytes as a control. On the day of oocyte retrieval, the number of sperm suitable for ICSI collected from two ejaculates or testicular sperm extraction was lower than the oocytes, and therefore, excess sibling oocytes were treated by IVF with donor sperm. From 72 couples (73 cycles), 1117 metaphase II oocytes were divided into 512 for ICSI and 605 for IVF. Compared with the control, husbands’ sperm produced a lower fertilization rate in nonobstructive azoospermia (65.4% vs 83.2%; P < 0.001), crytozoospermia (68.8% vs 75.5%; P < 0.05) and necrospermia (65.0% vs 85.2%; P < 0.05). The zygotes derived in nonobstructive azoospermia had a lower cleavage rate (96.4% vs 99.4%; P < 0.05), but the rate of resultant good-quality embryos was not different. Analysis of the rates of cleaved and good-quality embryos in crytozoospermia and necrospermia did not exhibit a significant difference from the control. In conclusion, although the sperm from severe male infertility reduced the fertilization ability, the derived embryos had potential developmental viabilities that might be predictive for the expected clinical outcomes.

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“…The choice of the fertilization method (IVF or ICSI) is based on semen parameters, oocyte quality and the outcome of previous IVF attempt (Shuai et al, 2015). Conventional IVF is known as an effective technique for fertilization and successful embryo development in case of non-male infertility factors.…”

Section: Oxidative Stress In Assisted Reproduction Techniques (Art)mentioning

confidence: 99%

Reactive oxygen species in reproduction: harmful, essential or both?

Jamil

Debbarh

Aboulmaouahib³

et al. 2020

Zygote

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Summary The process of embryonic development is crucial and radically influences preimplantation embryo competence. It involves oocyte maturation, fertilization, cell division and blastulation and is characterized by different key phases that have major influences on embryo quality. Each stage of the process of preimplantation embryonic development is led by important signalling pathways that include very many regulatory molecules, such as primary and secondary messengers. Many studies, both in vivo and in vitro, have shown the importance of the contribution of reactive oxygen species (ROS) as important second messengers in embryo development. ROS may originate from embryo metabolism and/or oocyte/embryo surroundings, and their effect on embryonic development is highly variable, depending on the needs of the embryo at each stage of development and on their environment (in vivo or under in vitro culture conditions). Other studies have also shown the deleterious effects of ROS in embryo development, when cellular tissue production overwhelms antioxidant production, leading to oxidative stress. This stress is known to be the cause of many cellular alterations, such as protein, lipid, and DNA damage. Considering that the same ROS level can have a deleterious effect on the fertilizing oocyte or embryo at certain stages, and a positive effect at another stage of the development process, further studies need to be carried out to determine the rate of ROS that benefits the embryo and from what rate it starts to be harmful, this measured at each key phase of embryonic development.

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Comparison of conventionalin vitrofertilisation and intracytoplasmic sperm injection outcomes in patients with moderate oligoasthenozoospermia

Cited by 22 publications

References 21 publications

ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model

ICSI versus Conventional IVF in Women Aged 40 Years or More and Unexplained Infertility: A Retrospective Evaluation of 685 Cycles with Propensity Score Model

ICSI treatment of severe male infertility can achieve prospective embryo quality compared with IVF of fertile donor sperm on sibling oocytes

Reactive oxygen species in reproduction: harmful, essential or both?

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