Comparison of conventional mechanical ventilation and high-frequency oscillatory ventilation in congenital diaphragmatic hernias: a systematic review and meta-analysis

Yang, Hee-Beom; Pierro, Agostino; Kim, Hyun-Young

doi:10.1038/s41598-023-42344-2

Cited by 2 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In management of CDH carefully instituted perinatal care plans are critically required especially for the respiratory system, monitoring of pulmonary hypertension and dealing with cardiac dysfunction. Permissive hypercapnia or 'gentle ventilation' has signi cantly contributed to marked improvements in survival for CDH [17]. The VICI trial found no differences in lung volume recruitment and / or outcome(s) of fatality and bronchopulmonary dysplasia comparing CDH patients who received conventional ventilation vs HOFV [18,19].…”

Section: Discussionmentioning

confidence: 99%

Utility of the Oxygenation Index in Management of Congenital Diaphragmatic Hernia – a Report From a Thai University Surgical Centre

Kulngamnetr,

Pongmee,

Losty

et al. 2024

Preprint

View full text Add to dashboard Cite

Background : Oxygenation index (OI) is associated with severity of newborn pulmonary hypertension (PH) in congenital diaphragmatic hernia (CDH). Higher OI may indicate worst degree(s) of PH. Objectives : This study reports OI dynamic(s) over the first 72 hours of life and its correlation with (i) perioperative morbidity and (ii) CDH mortality. Methods: Medical records of inborn CDH babies during 2002-2022 were examined. OI on Days (s) 1-3 and perioperative OI trends were recorded. Operation (primary vs patch repair) and survival rates (%) were studied. Results: 55 CDH newborns (54.5% male : 45.5% female) - mean birth GA 37.5±2.7 wks. had a mean birth weight 2813 ±684 g with prenatal diagnosis in 32.7% cases. 52/55 (94.5%) were intubated at birth and HFOV deployed in 29 (55.8%). Those requiring HFOV had higher OI on DOL1 (24.8± 17 vs 10.3±11.5; p< 0.05), DOL 2 (26.3± 22.9 vs 6.7±12.1; p < 0.05) and DOL 3 (21.9± 33.8 vs 5.5±9.3; p =0.04). Operation was undertaken in 36/55 (65.5%). Preoperative mortality group had significant higher OI on DOL 2 (42.1 ±21.0 vs 14.9±9.3; p =0.04). CDH defects were - Type A N=27 (75%), Type B N=7 (19.4%) and Type C N= 2 (5.6%). Overall mortality was 40% (22/55). Statistically significant OI trends were recorded in Non-Survival vs. Survival Groups on DOL 1 (31.6 ±16.8. vs 10.5±9.0; p <0.05, DOL 2 (38.1 ±21.9 vs 6.3±7.1; p <0.05), and DOL 3 (38.8 ±39.4; p=0.012) Conclusions: OI dynamics are highly predictive for accurate monitoring of CDH cardiorespiratory physiology and crucially may guide ventilatory management as well as timing of surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Utility of the Oxygenation Index in Management of Congenital Diaphragmatic Hernia – a Report From a Thai University Surgical Centre

Kulngamnetr,

Pongmee,

Losty

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Utility of the oxygenation index in management of congenital diaphragmatic hernia: a report from a Thai University Surgical Centre

Kulngamnetr,

Pongmee,

Losty

et al. 2024

Pediatr Surg Int

View full text Add to dashboard Cite

Background Oxygenation index (OI) is associated with severity of newborn pulmonary hypertension (PH) in congenital diaphragmatic hernia (CDH). Higher OI may indicate worst degree(s) of PH. Objectives This study reports OI dynamic(s) over the first 72 h of life and its correlation with (1) perioperative morbidity and (2) CDH mortality. Methods Medical records of inborn CDH babies during 2002–2022 were examined. OI on Days (s) 1–3 and perioperative OI trends were recorded. Operation (primary vs patch repair) and survival rates (%) were studied. Results Fifty-five CDH newborns (54.5% male: 45.5% female)—mean birth GA 37.5 ± 2.7 wks. had a mean birth weight 2813 ± 684 g with prenatal diagnosis in 32.7% cases. 52/55 (94.5%) were intubated at birth and HFOV deployed in 29 (55.8%). Those requiring HFOV had higher OI on DOL1 (24.8 ± 17 vs 10.3 ± 11.5; p < 0.05), DOL 2 (26.3 ± 22.9 vs 6.7 ± 12.1; p < 0.05) and DOL 3 (21.9 ± 33.8 vs 5.5 ± 9.3; p = 0.04). Operation was undertaken in 36/55 (65.5%). Preoperative mortality group had significant higher OI on DOL 2 (42.1 ± 21.0 vs 14.9 ± 9.3; p = 0.04). CDH defects were—Type A N = 27 (75%), Type B N = 7 (19.4%) and Type C N = 2 (5.6%). Overall mortality was 40% (22/55). Statistically significant OI trends were recorded in non-survival vs. survival groups on DOL 1 (31.6 ± 16.8. vs 10.5 ± 9.0; p < 0.05, DOL 2 (38.1 ± 21.9 vs 6.3 ± 7.1; p < 0.05), and DOL 3 (38.8 ± 39.4; p = 0.012). Conclusions OI dynamics are highly predictive for accurate monitoring of CDH cardiorespiratory physiology and crucially may guide ventilatory management as well as timing of surgery.

show abstract

Comparison of conventional mechanical ventilation and high-frequency oscillatory ventilation in congenital diaphragmatic hernias: a systematic review and meta-analysis

Cited by 2 publications

References 29 publications

Utility of the Oxygenation Index in Management of Congenital Diaphragmatic Hernia – a Report From a Thai University Surgical Centre

Utility of the Oxygenation Index in Management of Congenital Diaphragmatic Hernia – a Report From a Thai University Surgical Centre

Utility of the oxygenation index in management of congenital diaphragmatic hernia: a report from a Thai University Surgical Centre

Contact Info

Product

Resources

About